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B0S255

- NADK_FINM2

UniProt

B0S255 - NADK_FINM2

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Protein

NAD kinase

Gene

nadK

Organism
Finegoldia magna (strain ATCC 29328) (Peptostreptococcus magnus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei53 – 531Proton acceptorUniRule annotation
Binding sitei58 – 581NADUniRule annotation
Binding sitei157 – 1571NADUniRule annotation
Binding sitei192 – 1921NAD; via carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi53 – 542NADUniRule annotation
Nucleotide bindingi128 – 1292NADUniRule annotation
Nucleotide bindingi168 – 1736NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciFMAG334413:GJ6M-1078-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:FMG_1027
OrganismiFinegoldia magna (strain ATCC 29328) (Peptostreptococcus magnus)
Taxonomic identifieri334413 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiales Family XI. Incertae SedisFinegoldia
ProteomesiUP000001319: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273NAD kinasePRO_1000205417Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi334413.FMG_1027.

Structurei

3D structure databases

ProteinModelPortaliB0S255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000221177.
KOiK00858.
OMAiIQMSEIA.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

B0S255-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNNSKIINI YVNDNQKSLE TALIVKDKLE QKGFKPTFDF DENALINLCI
60 70 80 90 100
GGDGAFLRAV HKYEFSTIPF VGINTGHLGF YQEILIPNID KFISDLINEN
110 120 130 140 150
YGIEKISLLE SKTAIRNSSK TYTHKALNEF VVKSDDSSIV YLDVYIDDNH
160 170 180 190 200
LESFAGDGII VSTPSGSTAY NFSAGGSVLY HGLDGFQVTP LAPINSKAYR
210 220 230 240 250
SLLNSLVVPS KSNVTLYFRD HNFDRKSSIV LADGLNRSYD NVDYVNFTYS
260 270
DQYINKLVFL KDWYWLNIKD KFL
Length:273
Mass (Da):30,856
Last modified:April 8, 2008 - v1
Checksum:i469FEEC9B9D5247F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008971 Genomic DNA. Translation: BAG08445.1.
RefSeqiYP_001692335.1. NC_010376.1.

Genome annotation databases

EnsemblBacteriaiBAG08445; BAG08445; FMG_1027.
GeneIDi6018919.
KEGGifma:FMG_1027.
PATRICi21887731. VBIFinMag33027_1232.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008971 Genomic DNA. Translation: BAG08445.1 .
RefSeqi YP_001692335.1. NC_010376.1.

3D structure databases

ProteinModelPortali B0S255.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 334413.FMG_1027.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAG08445 ; BAG08445 ; FMG_1027 .
GeneIDi 6018919.
KEGGi fma:FMG_1027.
PATRICi 21887731. VBIFinMag33027_1232.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000221177.
KOi K00858.
OMAi IQMSEIA.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci FMAG334413:GJ6M-1078-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Finegoldia magna, an anaerobic opportunistic pathogen."
    Goto T., Yamashita A., Hirakawa H., Matsutani M., Todo K., Ohshima K., Toh H., Miyamoto K., Kuhara S., Hattori M., Shimizu T., Akimoto S.
    DNA Res. 15:39-47(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29328.

Entry informationi

Entry nameiNADK_FINM2
AccessioniPrimary (citable) accession number: B0S255
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3