B0S1R1 (GCH1_FINM2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase 1
EC=3.5.4.16

Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I

Gene names

Name:	folE
Ordered Locus Names:	FMG_0883

Organism

Finegoldia magna (strain ATCC 29328) (Peptostreptococcus magnus) [Complete proteome] [HAMAP]

Taxonomic identifier

334413 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiales incertae sedis › Clostridiales Family XI. Incertae Sedis › Finegoldia › Peptostreptococcus magnus

Protein attributes

Sequence length	184 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223
Subunit structure	Homopolymer By similarity.
Sequence similarities	Belongs to the GTP cyclohydrolase I family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	GTP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	7,8-dihydroneopterin 3'-triphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 184	184	GTP cyclohydrolase 1 HAMAP-Rule MF_00223		PRO_1000100174
Sites
	Metal binding	75	1	Zinc By similarity
	Metal binding	78	1	Zinc By similarity
	Metal binding	146	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0S1R1 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 76EDDB8F4F2529DE	FASTA	184	20,946
	10 20 30 40 50 60 MDKEKIEQAV SMIIEAIGED PNREGLLETP QRVARMYEEI FSGLNQDAKT HLSKSFEIVD 70 80 90 100 110 120 DNMVIEKDIP FYSMCEHHLL PFWGKVNIAY IPNKRVAGLS KLARTVDVYS KKPQLQERLN 130 140 150 160 170 180 IEIADALMEY LNCKGCLVTI EAEHMCMNMR GVKKPGTSTM TSVARGAFEE DLDLKNEAYR LMGL

References

[1]

"Complete genome sequence of Finegoldia magna, an anaerobic opportunistic pathogen." Goto T., Yamashita A., Hirakawa H., Matsutani M., Todo K., Ohshima K., Toh H., Miyamoto K., Kuhara S., Hattori M., Shimizu T., Akimoto S. DNA Res. 15:39-47(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29328.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008971 Genomic DNA. Translation: BAG08301.1.
RefSeq	YP_001692191.1. NC_010376.1.
3D structure databases
ProteinModelPortal	B0S1R1.
ModBase	Search...
Protein-protein interaction databases
STRING	334413.FMG_0883.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAG08301; BAG08301; FMG_0883.
GeneID	6018612.
KEGG	fma:FMG_0883.
PATRIC	21887445. VBIFinMag33027_1089.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0302.
HOGENOM	HOG000221222.
KO	K01495.
OMA	REIFGGY.
ProtClustDB	PRK09347.
Enzyme and pathway databases
BioCyc	FMAG334413:GJ6M-884-MONOMER.
UniPathway	UPA00848; UER00151.
Family and domain databases
HAMAP	MF_00223. FolE.
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
PANTHER	PTHR11109. PTHR11109. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
TIGRFAMs	TIGR00063. folE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH1_FINM2

Accession

Primary (citable) accession number: B0S1R1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	April 8, 2008
Last modified:	May 1, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program