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B0S101

- SYL_FINM2

UniProt

B0S101 - SYL_FINM2

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Finegoldia magna (strain ATCC 29328) (Peptostreptococcus magnus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei584 – 5841ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFMAG334413:GJ6M-667-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:FMG_0623
OrganismiFinegoldia magna (strain ATCC 29328) (Peptostreptococcus magnus)
Taxonomic identifieri334413 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiales Family XI. Incertae SedisFinegoldia
ProteomesiUP000001319: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 802802Leucine--tRNA ligasePRO_1000091319Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi334413.FMG_0623.

Structurei

3D structure databases

ProteinModelPortaliB0S101.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5212"HIGH" regionAdd
BLAST
Motifi581 – 5855"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiNENGVEG.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0S101-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDKYNPNSIE KKWQKYWEEN KTFKTSDDKS KKRFYALVEF PYPSGQGLHV
60 70 80 90 100
GHPRPYTALD IVSRKRRMQG YNVLYPMGWD AFGLPTENFA IKNKIRPEVV
110 120 130 140 150
TENNIKNFKR QMQSIGFSFD WDREINTTDP DYYKWTQWIF IQMFKKGLAY
160 170 180 190 200
KKEMPINWCP SCKTGLANEE VINGHCERCG GQVVRKVKNQ WMLKITEYAD
210 220 230 240 250
RLIDDLKDVD YFDRIKSQQI NWIGRSYGAE INFAVKEVDE KITVFTTRAD
260 270 280 290 300
TIFGATYMVI SVDHPLIEKY SDRIKNIDEI RSYRSEVAKK SELERTDLSK
310 320 330 340 350
EKTGYKIDGL TAINPLTNKE IPVYVSDYVL MTYGTGAIMA VPAHDDRDYE
360 370 380 390 400
FAKKFNIEMI PVIEGSDIQN CAFTETNEGN LINSGFLNGL TVDEAKEKMY
410 420 430 440 450
EYIEEKEIGH KKTNYKLRDW VFSRQRYWGE PIPLVYCEHC GWVPLDEKDL
460 470 480 490 500
PLVLPKVDNY EPTDNGESPL SKIDDFVHTK CPKCGRDAVR ETDTMPQWAG
510 520 530 540 550
SSWYYLRYTD PHNDEAIASK ENLDYYTPVD WYNGGMEHTT LHLLYSRFWH
560 570 580 590 600
KFLYDIGVVP TKEPYMKRTS HGMILGDNNE KMSKSRGNVV NPDDIVRDFG
610 620 630 640 650
ADTLRCYEMF IGDFEKSAPW SENGVKGCRK FLDKVWRTQD LVDGDSNFEK
660 670 680 690 700
METLIHQTIK KVSEDYENLK FNTAIAQLMT LLNEFNNLDK ISKEQFKIFL
710 720 730 740 750
ILLNPVCPHI TEEIWQRMGY EGYVHESSWP EYDESKTILD VIELPIQVNG
760 770 780 790 800
KLRATVEINR EASEDEVYEK AVKDDVVAKY LENKNVVKKI YVKGRIFNII

VK
Length:802
Mass (Da):93,768
Last modified:April 8, 2008 - v1
Checksum:i06571C3611F17057
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008971 Genomic DNA. Translation: BAG08041.1.
RefSeqiYP_001691931.1. NC_010376.1.

Genome annotation databases

EnsemblBacteriaiBAG08041; BAG08041; FMG_0623.
GeneIDi6020246.
KEGGifma:FMG_0623.
PATRICi21886909. VBIFinMag33027_0828.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008971 Genomic DNA. Translation: BAG08041.1 .
RefSeqi YP_001691931.1. NC_010376.1.

3D structure databases

ProteinModelPortali B0S101.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 334413.FMG_0623.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAG08041 ; BAG08041 ; FMG_0623 .
GeneIDi 6020246.
KEGGi fma:FMG_0623.
PATRICi 21886909. VBIFinMag33027_0828.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi NENGVEG.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci FMAG334413:GJ6M-667-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Finegoldia magna, an anaerobic opportunistic pathogen."
    Goto T., Yamashita A., Hirakawa H., Matsutani M., Todo K., Ohshima K., Toh H., Miyamoto K., Kuhara S., Hattori M., Shimizu T., Akimoto S.
    DNA Res. 15:39-47(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29328.

Entry informationi

Entry nameiSYL_FINM2
AccessioniPrimary (citable) accession number: B0S101
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3