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B0S0G1

- FTHS_FINM2

UniProt

B0S0G1 - FTHS_FINM2

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Finegoldia magna (strain ATCC 29328) (Peptostreptococcus magnus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi67 – 748ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciFMAG334413:GJ6M-480-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:FMG_0461
    OrganismiFinegoldia magna (strain ATCC 29328) (Peptostreptococcus magnus)
    Taxonomic identifieri334413 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiales Family XI. Incertae SedisFinegoldia
    ProteomesiUP000001319: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 554554Formate--tetrahydrofolate ligasePRO_1000146683Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi334413.FMG_0461.

    Structurei

    3D structure databases

    ProteinModelPortaliB0S0G1.
    SMRiB0S0G1. Positions 6-552.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0S0G1-1 [UniParc]FASTAAdd to Basket

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    MFMATDVEIA QKAKLEKISV IAEKMGLTEE DYEQYGRYKA KLDLNLFEKN    50
    KDKKDGKLIL MTSINPTPTG EGKTTMNVGL AMGLNKIGKN AISVLREPSL 100
    GPNFGMKGGA AGGGYAQVVP MDEINMHFTG DFHAITTANN LICAMMDNHI 150
    HQGNALNIDP KQILIKRCMD MNERELRDII IGVGAKGNGV MRQDGFEITV 200
    ASEIMAILCL AKDLKDLKER VGNILIAFDK EGKPVYARDV KADGAVALVM 250
    KEAIKPNLVQ TLEHTPAIIH GGPFANIAHG CNSLIATKLG LKLGDYVVTE 300
    AGFGADLGAE KFFDIKCRND LHPNMVCIVA TIKALKHHGE AEDFKVENVE 350
    ALEKGYANLK RHIENMKKYK VPVVVAINRF ATDTDAEIKK LTELVEADGT 400
    RAIFCDVWAK GGEGAKELAE YVVENTKEEN DFEFLYDLEL PIKEKIEKIA 450
    KEIYRADGVE FSAKAKKKLK QIKELGLDNY PVCMAKTQYS FSDNKKLIGA 500
    PTGFTITVSD FKISRGAGFV VALLGSVMTM PGLPKVPSAE NCDVLDDGTV 550
    VGLF 554
    Length:554
    Mass (Da):60,642
    Last modified:April 8, 2008 - v1
    Checksum:iF0846196F79BA3D2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008971 Genomic DNA. Translation: BAG07879.1.
    RefSeqiWP_012290418.1. NC_010376.1.
    YP_001691769.1. NC_010376.1.

    Genome annotation databases

    EnsemblBacteriaiBAG07879; BAG07879; FMG_0461.
    GeneIDi6020131.
    KEGGifma:FMG_0461.
    PATRICi21886529. VBIFinMag33027_0663.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008971 Genomic DNA. Translation: BAG07879.1 .
    RefSeqi WP_012290418.1. NC_010376.1.
    YP_001691769.1. NC_010376.1.

    3D structure databases

    ProteinModelPortali B0S0G1.
    SMRi B0S0G1. Positions 6-552.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 334413.FMG_0461.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAG07879 ; BAG07879 ; FMG_0461 .
    GeneIDi 6020131.
    KEGGi fma:FMG_0461.
    PATRICi 21886529. VBIFinMag33027_0663.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci FMAG334413:GJ6M-480-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Finegoldia magna, an anaerobic opportunistic pathogen."
      Goto T., Yamashita A., Hirakawa H., Matsutani M., Todo K., Ohshima K., Toh H., Miyamoto K., Kuhara S., Hattori M., Shimizu T., Akimoto S.
      DNA Res. 15:39-47(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29328.

    Entry informationi

    Entry nameiFTHS_FINM2
    AccessioniPrimary (citable) accession number: B0S0G1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3