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B0S0G1 (FTHS_FINM2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:FMG_0461
OrganismFinegoldia magna (strain ATCC 29328) (Peptostreptococcus magnus) [Complete proteome] [HAMAP]
Taxonomic identifier334413 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiales Family XI. Incertae SedisFinegoldia

Protein attributes

Sequence length554 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 554554Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000146683

Regions

Nucleotide binding67 – 748ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B0S0G1 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: F0846196F79BA3D2

FASTA55460,642
        10         20         30         40         50         60 
MFMATDVEIA QKAKLEKISV IAEKMGLTEE DYEQYGRYKA KLDLNLFEKN KDKKDGKLIL 

        70         80         90        100        110        120 
MTSINPTPTG EGKTTMNVGL AMGLNKIGKN AISVLREPSL GPNFGMKGGA AGGGYAQVVP 

       130        140        150        160        170        180 
MDEINMHFTG DFHAITTANN LICAMMDNHI HQGNALNIDP KQILIKRCMD MNERELRDII 

       190        200        210        220        230        240 
IGVGAKGNGV MRQDGFEITV ASEIMAILCL AKDLKDLKER VGNILIAFDK EGKPVYARDV 

       250        260        270        280        290        300 
KADGAVALVM KEAIKPNLVQ TLEHTPAIIH GGPFANIAHG CNSLIATKLG LKLGDYVVTE 

       310        320        330        340        350        360 
AGFGADLGAE KFFDIKCRND LHPNMVCIVA TIKALKHHGE AEDFKVENVE ALEKGYANLK 

       370        380        390        400        410        420 
RHIENMKKYK VPVVVAINRF ATDTDAEIKK LTELVEADGT RAIFCDVWAK GGEGAKELAE 

       430        440        450        460        470        480 
YVVENTKEEN DFEFLYDLEL PIKEKIEKIA KEIYRADGVE FSAKAKKKLK QIKELGLDNY 

       490        500        510        520        530        540 
PVCMAKTQYS FSDNKKLIGA PTGFTITVSD FKISRGAGFV VALLGSVMTM PGLPKVPSAE 

       550 
NCDVLDDGTV VGLF 

« Hide

References

[1]"Complete genome sequence of Finegoldia magna, an anaerobic opportunistic pathogen."
Goto T., Yamashita A., Hirakawa H., Matsutani M., Todo K., Ohshima K., Toh H., Miyamoto K., Kuhara S., Hattori M., Shimizu T., Akimoto S.
DNA Res. 15:39-47(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29328.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008971 Genomic DNA. Translation: BAG07879.1.
RefSeqYP_001691769.1. NC_010376.1.

3D structure databases

ProteinModelPortalB0S0G1.
SMRB0S0G1. Positions 6-552.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING334413.FMG_0461.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAG07879; BAG07879; FMG_0461.
GeneID6020131.
KEGGfma:FMG_0461.
PATRIC21886529. VBIFinMag33027_0663.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMALKHHGGV.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycFMAG334413:GJ6M-480-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_FINM2
AccessionPrimary (citable) accession number: B0S0G1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways