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B0S0G1

- FTHS_FINM2

UniProt

B0S0G1 - FTHS_FINM2

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Finegoldia magna (strain ATCC 29328) (Peptostreptococcus magnus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 748ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFMAG334413:GJ6M-480-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:FMG_0461
OrganismiFinegoldia magna (strain ATCC 29328) (Peptostreptococcus magnus)
Taxonomic identifieri334413 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiales Family XI. Incertae SedisFinegoldia
ProteomesiUP000001319: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554Formate--tetrahydrofolate ligasePRO_1000146683Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi334413.FMG_0461.

Structurei

3D structure databases

ProteinModelPortaliB0S0G1.
SMRiB0S0G1. Positions 6-552.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0S0G1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFMATDVEIA QKAKLEKISV IAEKMGLTEE DYEQYGRYKA KLDLNLFEKN
60 70 80 90 100
KDKKDGKLIL MTSINPTPTG EGKTTMNVGL AMGLNKIGKN AISVLREPSL
110 120 130 140 150
GPNFGMKGGA AGGGYAQVVP MDEINMHFTG DFHAITTANN LICAMMDNHI
160 170 180 190 200
HQGNALNIDP KQILIKRCMD MNERELRDII IGVGAKGNGV MRQDGFEITV
210 220 230 240 250
ASEIMAILCL AKDLKDLKER VGNILIAFDK EGKPVYARDV KADGAVALVM
260 270 280 290 300
KEAIKPNLVQ TLEHTPAIIH GGPFANIAHG CNSLIATKLG LKLGDYVVTE
310 320 330 340 350
AGFGADLGAE KFFDIKCRND LHPNMVCIVA TIKALKHHGE AEDFKVENVE
360 370 380 390 400
ALEKGYANLK RHIENMKKYK VPVVVAINRF ATDTDAEIKK LTELVEADGT
410 420 430 440 450
RAIFCDVWAK GGEGAKELAE YVVENTKEEN DFEFLYDLEL PIKEKIEKIA
460 470 480 490 500
KEIYRADGVE FSAKAKKKLK QIKELGLDNY PVCMAKTQYS FSDNKKLIGA
510 520 530 540 550
PTGFTITVSD FKISRGAGFV VALLGSVMTM PGLPKVPSAE NCDVLDDGTV

VGLF
Length:554
Mass (Da):60,642
Last modified:April 8, 2008 - v1
Checksum:iF0846196F79BA3D2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008971 Genomic DNA. Translation: BAG07879.1.
RefSeqiYP_001691769.1. NC_010376.1.

Genome annotation databases

EnsemblBacteriaiBAG07879; BAG07879; FMG_0461.
GeneIDi6020131.
KEGGifma:FMG_0461.
PATRICi21886529. VBIFinMag33027_0663.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008971 Genomic DNA. Translation: BAG07879.1 .
RefSeqi YP_001691769.1. NC_010376.1.

3D structure databases

ProteinModelPortali B0S0G1.
SMRi B0S0G1. Positions 6-552.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 334413.FMG_0461.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAG07879 ; BAG07879 ; FMG_0461 .
GeneIDi 6020131.
KEGGi fma:FMG_0461.
PATRICi 21886529. VBIFinMag33027_0663.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci FMAG334413:GJ6M-480-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Finegoldia magna, an anaerobic opportunistic pathogen."
    Goto T., Yamashita A., Hirakawa H., Matsutani M., Todo K., Ohshima K., Toh H., Miyamoto K., Kuhara S., Hattori M., Shimizu T., Akimoto S.
    DNA Res. 15:39-47(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29328.

Entry informationi

Entry nameiFTHS_FINM2
AccessioniPrimary (citable) accession number: B0S0G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3