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B0S093 (DDL_FINM2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:FMG_0263
OrganismFinegoldia magna (strain ATCC 29328) (Peptostreptococcus magnus) [Complete proteome] [HAMAP]
Taxonomic identifier334413 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiales Family XI. Incertae SedisFinegoldia

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000341091

Regions

Domain133 – 334202ATP-grasp
Nucleotide binding161 – 21656ATP By similarity

Sites

Metal binding2881Magnesium or manganese 1 By similarity
Metal binding3001Magnesium or manganese 1 By similarity
Metal binding3001Magnesium or manganese 2 By similarity
Metal binding3021Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
B0S093 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 67D67C1E85E7DF61

FASTA35039,895
        10         20         30         40         50         60 
MQKNIYVLYG GPSTEHEVSI TSARTLINNL SKEKYNVNAI FVRRNKKFIM KENITEEIKS 

        70         80         90        100        110        120 
DEELILDTDL SVIESVSECI RKINPENTVI FPAIHGSYGE DGTIQGFIKV LDLPFVGCNV 

       130        140        150        160        170        180 
LGSALCMDKG YTNDIFELNK IPQAKYVVLC KNDDYNLKEI FEKTSKAVYV KPCNAGSSVG 

       190        200        210        220        230        240 
VMRAETEEEL EKAIQNAFQY DRRILVEEEI IGPELQIAVM GNDNPVASRP GVYQIHDVEF 

       250        260        270        280        290        300 
FDYDAKYNDS KTEMLTPFPM DEKLELKARH LAEKVYKLMS LSGFSRVDMF VKDNELWVNE 

       310        320        330        340        350 
INTVPGLTPH SMFPVLWKCT NDMSVSEVFD NLIGLAVEEY KKNKAYKLER 

« Hide

References

[1]"Complete genome sequence of Finegoldia magna, an anaerobic opportunistic pathogen."
Goto T., Yamashita A., Hirakawa H., Matsutani M., Todo K., Ohshima K., Toh H., Miyamoto K., Kuhara S., Hattori M., Shimizu T., Akimoto S.
DNA Res. 15:39-47(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29328.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008971 Genomic DNA. Translation: BAG07681.1.
RefSeqYP_001691571.1. NC_010376.1.

3D structure databases

ProteinModelPortalB0S093.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING334413.FMG_0263.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAG07681; BAG07681; FMG_0263.
GeneID6019794.
KEGGfma:FMG_0263.
PATRIC21886133. VBIFinMag33027_0467.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAKLAFQYD.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

BioCycFMAG334413:GJ6M-280-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_FINM2
AccessionPrimary (citable) accession number: B0S093
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways