B0RYU5 (B0RYU5_XANCB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123

Alternative name(s):
Acetate--CoA ligase HAMAP MF_01123
Acyl-activating enzyme HAMAP MF_01123

Gene names

Name:	acsA HAMAP MF_01123 EMBL CAP53631.1
Ordered Locus Names:	xcc-b100_4261

Organism

Xanthomonas campestris pv. campestris (strain B100) [Complete proteome] [HAMAP]

Taxonomic identifier

509169 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length	672 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_01123 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01123 EMBL CAP53631.1
PTM	Acetylation HAMAP MF_01123
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	541	1	By similarity HAMAP MF_01123
Amino acid modifications
	Modified residue	633	1	N6-acetyllysine By similarity HAMAP MF_01123

Sequences

	Sequence		Length	Mass (Da)
	B0RYU5 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: C1DB0AB7331FB307	FASTA	672	74,148
	10 20 30 40 50 60 MRHTDCLRGA RKRPSSDKLI ASEGAMADVY PVDPAFAADA RITREQYATL YRESIEHPEQ 70 80 90 100 110 120 FWGKAAQRLD WFKQPTQIKD VSFALDDFHV RWFGDGELNA SVNCLDRQLA TRGDKTALLF 130 140 150 160 170 180 EPDSPDSPSY PVTYRELYER VCKLGNALRN LGVKKGDRVT IYLPMIVDAA VAMLACARIG 190 200 210 220 230 240 AVHSVVFGGF AANSIADRVI DCQSKLIITA DEGLRGGKKI PLKANVDAAL KIPGTNTVET 250 260 270 280 290 300 VLVVRHTGGA VDMQAPRDRW FHDVVDGQPA ECEPERMNAE DPLFILYTSG STGKPKGVLH 310 320 330 340 350 360 TTAGYLLFAS YTHEVVFDLR EDDIYWCTAD VGWVTGHSYI VYGPLANGAT AVMFEGVPNY 370 380 390 400 410 420 PNVSRFWEVI DKHQVTIFYT APTAIRALMR EGEAPVKKTS RSSLRLLGSV GEPINPEAWR 430 440 450 460 470 480 WYYEVVGDSR CPIVDTWWQT ETGGILISPL AGAVDLKPGS ATLPFFGVQP ALVDAEGKIL 490 500 510 520 530 540 EGATEGNLVL LDSWPGQMRT VYGDHQRFID TYFRTYPGSY FTGDGCRRDA DGYYWITGRV 550 560 570 580 590 600 DDVINVSGHR IGTAEVESAL VSHPKVAEAA VVGFPHDVKG QGIYAYVTLI AGETPSEELH 610 620 630 640 650 660 KELVSWVRKE IGPIASPDHL QWAPGLPKTR SGKIMRRILR KIAENAPDQL GDTSTLADPS 670 VVDSLVNERL TR

References

[1]

"The genome of Xanthomonas campestris pv. campestris B100 and its use for the reconstruction of metabolic pathways involved in xanthan biosynthesis." Vorhoelter F.-J., Schneiker S., Goesmann A., Krause L., Bekel T., Kaiser O., Linke B., Patschkowski T., Rueckert C., Schmid J., Sidhu V.K., Sieber V., Tauch A., Watt S.A., Weisshaar B., Becker A., Niehaus K., Puehler A. J. Biotechnol. 134:33-45(2008) [PubMed: 18304669] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM920689 Genomic DNA. Translation: CAP53631.1.
RefSeq	YP_001905666.1. NC_010688.1.
3D structure databases
ProteinModelPortal	B0RYU5.
SMR	B0RYU5. Positions 34-669.
ModBase	Search...
Protein-protein interaction databases
STRING	B0RYU5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6324038.
GenomeReviews	Gene locus xcc-b100_4261 in contig AM920689_GR.
PATRIC	24088543. VBIXanCam108527_4322.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG547964.
OMA	HQRMVDT.
ProtClustDB	PRK00174.
Enzyme and pathway databases
BioCyc	XCAM487884:XCC-B100_4261-MONOMER.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B0RYU5_XANCB

Accession

Primary (citable) accession number: B0RYU5

Entry history

Integrated into UniProtKB/TrEMBL:	April 8, 2008
Last sequence update:	April 8, 2008
Last modified:	December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)