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B0RXM3

- DUT_XANCB

UniProt

B0RXM3 - DUT_XANCB

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

dut

Organism
Xanthomonas campestris pv. campestris (strain B100)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.UniRule annotation

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei84 – 841SubstrateUniRule annotation

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dUMP biosynthetic process Source: UniProtKB-UniPathway
    2. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciXCAM509169:GHW4-4135-MONOMER.
    UniPathwayiUPA00610; UER00666.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
    Short name:
    dUTPaseUniRule annotation
    Alternative name(s):
    dUTP pyrophosphataseUniRule annotation
    Gene namesi
    Name:dutUniRule annotation
    Ordered Locus Names:xcc-b100_4042
    OrganismiXanthomonas campestris pv. campestris (strain B100)
    Taxonomic identifieri509169 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
    ProteomesiUP000001188: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 152152Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_1000095001Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi509169.xccb100_4042.

    Structurei

    3D structure databases

    ProteinModelPortaliB0RXM3.
    SMRiB0RXM3. Positions 1-136.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni71 – 733Substrate bindingUniRule annotation
    Regioni88 – 903Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the dUTPase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0756.
    KOiK01520.
    OMAiSIYIGDP.
    OrthoDBiEOG689HXK.

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    HAMAPiMF_00116. dUTPase_bact.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.
    TIGRFAMsiTIGR00576. dut. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B0RXM3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQSLQVKLL DPRFGDLWPL PAYATEASAG MDLRAALEAP MTLEPGDAAL    50
    IPSGIAIHLD DPQVCAVILP RSGLGHRHGI VLGNGTGLID ADYQGPLLIS 100
    TWNRGREAFT IEPGDRIAQL VILPIVRVSL QVVDTFVDSA RGAGGFGHTG 150
    VR 152
    Length:152
    Mass (Da):16,085
    Last modified:April 8, 2008 - v1
    Checksum:i7EB25119DDA03940
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM920689 Genomic DNA. Translation: CAP53409.1.
    RefSeqiYP_001905447.1. NC_010688.1.

    Genome annotation databases

    EnsemblBacteriaiCAP53409; CAP53409; xcc-b100_4042.
    GeneIDi6324759.
    KEGGixca:xccb100_4042.
    PATRICi24088077. VBIXanCam108527_4093.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM920689 Genomic DNA. Translation: CAP53409.1 .
    RefSeqi YP_001905447.1. NC_010688.1.

    3D structure databases

    ProteinModelPortali B0RXM3.
    SMRi B0RXM3. Positions 1-136.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 509169.xccb100_4042.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAP53409 ; CAP53409 ; xcc-b100_4042 .
    GeneIDi 6324759.
    KEGGi xca:xccb100_4042.
    PATRICi 24088077. VBIXanCam108527_4093.

    Phylogenomic databases

    eggNOGi COG0756.
    KOi K01520.
    OMAi SIYIGDP.
    OrthoDBi EOG689HXK.

    Enzyme and pathway databases

    UniPathwayi UPA00610 ; UER00666 .
    BioCyci XCAM509169:GHW4-4135-MONOMER.

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    HAMAPi MF_00116. dUTPase_bact.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    TIGRFAMsi TIGR00576. dut. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Xanthomonas campestris pv. campestris B100 and its use for the reconstruction of metabolic pathways involved in xanthan biosynthesis."
      Vorhoelter F.-J., Schneiker S., Goesmann A., Krause L., Bekel T., Kaiser O., Linke B., Patschkowski T., Rueckert C., Schmid J., Sidhu V.K., Sieber V., Tauch A., Watt S.A., Weisshaar B., Becker A., Niehaus K., Puehler A.
      J. Biotechnol. 134:33-45(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: B100.

    Entry informationi

    Entry nameiDUT_XANCB
    AccessioniPrimary (citable) accession number: B0RXM3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3