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B0RVK6

- XANB_XANCB

UniProt

B0RVK6 - XANB_XANCB

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Protein

Xanthan biosynthesis protein XanB

Gene

xanB

Organism
Xanthomonas campestris pv. campestris (strain B100)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in xanthan production.

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.
GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.

Pathwayi

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. mannose-1-phosphate guanylyltransferase activity Source: UniProtKB-EC
  3. mannose-6-phosphate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
  2. lipopolysaccharide biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

Exopolysaccharide synthesis, Lipopolysaccharide biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-3299-MONOMER.
XCAM509169:GHW4-3816-MONOMER.
UniPathwayiUPA00126; UER00423.
UPA00126; UER00930.

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthan biosynthesis protein XanB
Including the following 2 domains:
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name:
PMI
Mannose-1-phosphate guanylyl transferase (EC:2.7.7.13)
Alternative name(s):
GDP-mannose pyrophosphorylase
Short name:
GMP
Short name:
GMPP
Gene namesi
Name:xanB
Ordered Locus Names:xcc-b100_3730
OrganismiXanthomonas campestris pv. campestris (strain B100)
Taxonomic identifieri509169 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000001188: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Xanthan biosynthesis protein XanBPRO_0000333187Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi509169.xccb100_3730.

Structurei

3D structure databases

ProteinModelPortaliB0RVK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0662.
KOiK16011.
OMAiIYAACEQ.
OrthoDBiEOG6X3W6T.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
3.90.550.10. 1 hit.
InterProiIPR006375. Man1P_GuaTrfase/Man6P_Isoase.
IPR001538. Man6P_isomerase-2_C.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF01050. MannoseP_isomer. 1 hit.
PF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
SSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01479. GMP_PMI. 1 hit.

Sequencei

Sequence statusi: Complete.

B0RVK6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDVLPIILS GGSGTRLWPL SRETYPKQFL PLVGEHSMLQ ATWLRSAPVA
60 70 80 90 100
AHAPIVVANE EHRFMAAEQL QQLGVKPSAI LLEPKGRNTA PAIAVAALEA
110 120 130 140 150
TRNGGDPLLL VLPSDHVIRD EAAFQAAVTV AAAAAEQGKL VTFGIKPTAP
160 170 180 190 200
ETGYGYIKAG AGTGATAVER FVEKPDLATA QGYLASGEYY WNSGMFLFRA
210 220 230 240 250
SRYLEELRKF QPAIADACQK AWEGGKRDAD FTRLDKDAFA SSPSDSIDYA
260 270 280 290 300
VMEKTADAVV VPLDAGWNDV GSWSSLLDVS EQDGQGNAHH GDVIQLDCKN
310 320 330 340 350
TYAYGSRLIA MVGLENVVVV ETDDAVLVGH RDRIQEVKEV VSQIKSAGRS
360 370 380 390 400
EATWHRKVYR PWGAYDSIDM GQRFQVKRIT VKPGATLSLQ MHHHRAEHWI
410 420 430 440 450
VVSGTAEVTR GDEVLLLTEN QSTYIPLGVT HRLKNPGKLP LELIEVQSGS
460
YLGEDDIVRF EDTYGRT
Length:467
Mass (Da):50,934
Last modified:April 8, 2008 - v1
Checksum:i596DEEFFA93FC78A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204145 Genomic DNA. Translation: AAK53463.1.
AM920689 Genomic DNA. Translation: CAP53097.1.
PIRiB43304.
RefSeqiYP_001905135.1. NC_010688.1.

Genome annotation databases

EnsemblBacteriaiCAP53097; CAP53097; xcc-b100_3730.
GeneIDi6325210.
KEGGixca:xccb100_3730.
PATRICi24087412. VBIXanCam108527_3767.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204145 Genomic DNA. Translation: AAK53463.1 .
AM920689 Genomic DNA. Translation: CAP53097.1 .
PIRi B43304.
RefSeqi YP_001905135.1. NC_010688.1.

3D structure databases

ProteinModelPortali B0RVK6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 509169.xccb100_3730.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAP53097 ; CAP53097 ; xcc-b100_3730 .
GeneIDi 6325210.
KEGGi xca:xccb100_3730.
PATRICi 24087412. VBIXanCam108527_3767.

Phylogenomic databases

eggNOGi COG0662.
KOi K16011.
OMAi IYAACEQ.
OrthoDBi EOG6X3W6T.

Enzyme and pathway databases

UniPathwayi UPA00126 ; UER00423 .
UPA00126 ; UER00930 .
BioCyci RETL1328306-WGS:GSTH-3299-MONOMER.
XCAM509169:GHW4-3816-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
3.90.550.10. 1 hit.
InterProi IPR006375. Man1P_GuaTrfase/Man6P_Isoase.
IPR001538. Man6P_isomerase-2_C.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
Pfami PF01050. MannoseP_isomer. 1 hit.
PF00483. NTP_transferase. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR01479. GMP_PMI. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genetics of xanthan production in Xanthomonas campestris: the xanA and xanB genes are involved in UDP-glucose and GDP-mannose biosynthesis."
    Koeplin R., Arnold W., Hoette B., Simon R., Wang G., Puehler A.
    J. Bacteriol. 174:191-199(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Lipopolysaccharide biosynthesis in Xanthomonas campestris pv. campestris: a cluster of 15 genes is involved in the biosynthesis of the LPS O-antigen and the LPS core."
    Vorhoelter F.-J., Niehaus K., Puehler A.
    Mol. Genet. Genomics 266:79-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 164.
  3. "The genome of Xanthomonas campestris pv. campestris B100 and its use for the reconstruction of metabolic pathways involved in xanthan biosynthesis."
    Vorhoelter F.-J., Schneiker S., Goesmann A., Krause L., Bekel T., Kaiser O., Linke B., Patschkowski T., Rueckert C., Schmid J., Sidhu V.K., Sieber V., Tauch A., Watt S.A., Weisshaar B., Becker A., Niehaus K., Puehler A.
    J. Biotechnol. 134:33-45(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B100.

Entry informationi

Entry nameiXANB_XANCB
AccessioniPrimary (citable) accession number: B0RVK6
Secondary accession number(s): P29956, Q93S98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3