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Protein

Phosphohexose mutases

Gene

xanA

Organism
Xanthomonas campestris pv. campestris (strain B100)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in xanthan production.

Catalytic activityi

Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Pathway: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Xanthan biosynthesis protein XanB (xanB)
  2. Phosphohexose mutases (xanA)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei97 – 971Phosphoserine intermediateBy similarity
Metal bindingi97 – 971Magnesium; via phosphate groupBy similarity
Metal bindingi237 – 2371MagnesiumBy similarity
Metal bindingi239 – 2391MagnesiumBy similarity
Metal bindingi241 – 2411MagnesiumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Exopolysaccharide synthesis, Lipopolysaccharide biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciXCAM509169:GHW4-3815-MONOMER.
UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphohexose mutases
Including the following 2 domains:
Phosphoglucomutase (EC:5.4.2.2)
Short name:
PGM
Alternative name(s):
Glucose phosphomutase
Phosphomannomutase (EC:5.4.2.8)
Short name:
PMM
Gene namesi
Name:xanA
Ordered Locus Names:xcc-b100_3729
OrganismiXanthomonas campestris pv. campestris (strain B100)
Taxonomic identifieri509169 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000001188 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Phosphohexose mutasesPRO_0000333186Add
BLAST

Keywords - PTMi

Phosphoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGiCOG1109.
KOiK15778.
OMAiSIEYPNW.
OrthoDBiEOG6W9X55.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0RVK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLPAFKAYD IRGRVPDELN EDLARRIGVA LAAQLDQGPV VLGHDVRLAS
60 70 80 90 100
PALQEALSAG LRASGREVID IGLCGTEEVY FQTDHLKAAG GVMVTASHNP
110 120 130 140 150
MDYNGMKLVR EQARPISSDT GLFAIRDTVA ADTAAAGEPT AAEHSRTDKT
160 170 180 190 200
AYLEHLLSYV DRSTLKPLKL VVNAGNGGAG LIVDLLAPHL PFEFVRVFHE
210 220 230 240 250
PDGNFPNGIP NPLLQENRDA TAKAVKEHGA DFGIAWDGDF DRCFFFDHTG
260 270 280 290 300
RFIEGYYLVG LLAQAILAKQ PGGKVVHDPR LTWNTVEMVE DAGGIPVLCK
310 320 330 340 350
SGHAFIKEKM RSENAVYGGE MSAHHYFREF AYADSGMIPW LLIAELVSQS
360 370 380 390 400
GRSLADLVEA RMQKFPCSGE INFKVDDAKA AVARVMAHYG DQSPELDYTD
410 420 430 440
GISADFGQWR FNLRSSNTEP LLRLNVETRG DAALLETRTQ EISNLLRG
Length:448
Mass (Da):48,922
Last modified:April 8, 2008 - v1
Checksum:i221961862CAEAB8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204145 Genomic DNA. Translation: AAA27610.1.
AM920689 Genomic DNA. Translation: CAP53096.1.
PIRiA43304.
RefSeqiWP_012439274.1. NC_010688.1.
YP_001905134.1. NC_010688.1.

Genome annotation databases

EnsemblBacteriaiCAP53096; CAP53096; xcc-b100_3729.
KEGGixca:xccb100_3729.
PATRICi24087410. VBIXanCam108527_3766.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204145 Genomic DNA. Translation: AAA27610.1.
AM920689 Genomic DNA. Translation: CAP53096.1.
PIRiA43304.
RefSeqiWP_012439274.1. NC_010688.1.
YP_001905134.1. NC_010688.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAP53096; CAP53096; xcc-b100_3729.
KEGGixca:xccb100_3729.
PATRICi24087410. VBIXanCam108527_3766.

Phylogenomic databases

eggNOGiCOG1109.
KOiK15778.
OMAiSIEYPNW.
OrthoDBiEOG6W9X55.

Enzyme and pathway databases

UniPathwayiUPA00126; UER00424.
BioCyciXCAM509169:GHW4-3815-MONOMER.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genetics of xanthan production in Xanthomonas campestris: the xanA and xanB genes are involved in UDP-glucose and GDP-mannose biosynthesis."
    Koeplin R., Arnold W., Hoette B., Simon R., Wang G., Puehler A.
    J. Bacteriol. 174:191-199(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome of Xanthomonas campestris pv. campestris B100 and its use for the reconstruction of metabolic pathways involved in xanthan biosynthesis."
    Vorhoelter F.-J., Schneiker S., Goesmann A., Krause L., Bekel T., Kaiser O., Linke B., Patschkowski T., Rueckert C., Schmid J., Sidhu V.K., Sieber V., Tauch A., Watt S.A., Weisshaar B., Becker A., Niehaus K., Puehler A.
    J. Biotechnol. 134:33-45(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B100.

Entry informationi

Entry nameiXANA_XANCB
AccessioniPrimary (citable) accession number: B0RVK5
Secondary accession number(s): P29955
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: June 24, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.