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B0RVK5

- XANA_XANCB

UniProt

B0RVK5 - XANA_XANCB

Protein

Phosphohexose mutases

Gene

xanA

Organism
Xanthomonas campestris pv. campestris (strain B100)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Involved in xanthan production.

    Catalytic activityi

    Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
    Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei97 – 971Phosphoserine intermediateBy similarity
    Metal bindingi97 – 971Magnesium; via phosphate groupBy similarity
    Metal bindingi237 – 2371MagnesiumBy similarity
    Metal bindingi239 – 2391MagnesiumBy similarity
    Metal bindingi241 – 2411MagnesiumBy similarity

    GO - Molecular functioni

    1. magnesium ion binding Source: InterPro
    2. phosphoglucomutase activity Source: UniProtKB-EC
    3. phosphomannomutase activity Source: UniProtKB-EC

    GO - Biological processi

    1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
    2. lipopolysaccharide biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Exopolysaccharide synthesis, Lipopolysaccharide biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciXCAM509169:GHW4-3815-MONOMER.
    UniPathwayiUPA00126; UER00424.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphohexose mutases
    Including the following 2 domains:
    Phosphoglucomutase (EC:5.4.2.2)
    Short name:
    PGM
    Alternative name(s):
    Glucose phosphomutase
    Phosphomannomutase (EC:5.4.2.8)
    Short name:
    PMM
    Gene namesi
    Name:xanA
    Ordered Locus Names:xcc-b100_3729
    OrganismiXanthomonas campestris pv. campestris (strain B100)
    Taxonomic identifieri509169 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
    ProteomesiUP000001188: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 448448Phosphohexose mutasesPRO_0000333186Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi509169.xccb100_3729.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phosphohexose mutase family.Curated

    Phylogenomic databases

    eggNOGiCOG1109.
    KOiK15778.
    OMAiVVGCDIR.
    OrthoDBiEOG6W9X55.

    Family and domain databases

    Gene3Di3.30.310.50. 1 hit.
    3.40.120.10. 3 hits.
    InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
    IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
    IPR005845. A-D-PHexomutase_a/b/a-II.
    IPR005846. A-D-PHexomutase_a/b/a-III.
    IPR005843. A-D-PHexomutase_C.
    IPR016066. A-D-PHexomutase_CS.
    IPR005841. Alpha-D-phosphohexomutase_SF.
    [Graphical view]
    PfamiPF02878. PGM_PMM_I. 1 hit.
    PF02879. PGM_PMM_II. 1 hit.
    PF02880. PGM_PMM_III. 1 hit.
    PF00408. PGM_PMM_IV. 1 hit.
    [Graphical view]
    PRINTSiPR00509. PGMPMM.
    SUPFAMiSSF53738. SSF53738. 3 hits.
    SSF55957. SSF55957. 1 hit.
    PROSITEiPS00710. PGM_PMM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0RVK5-1 [UniParc]FASTAAdd to Basket

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    MTLPAFKAYD IRGRVPDELN EDLARRIGVA LAAQLDQGPV VLGHDVRLAS    50
    PALQEALSAG LRASGREVID IGLCGTEEVY FQTDHLKAAG GVMVTASHNP 100
    MDYNGMKLVR EQARPISSDT GLFAIRDTVA ADTAAAGEPT AAEHSRTDKT 150
    AYLEHLLSYV DRSTLKPLKL VVNAGNGGAG LIVDLLAPHL PFEFVRVFHE 200
    PDGNFPNGIP NPLLQENRDA TAKAVKEHGA DFGIAWDGDF DRCFFFDHTG 250
    RFIEGYYLVG LLAQAILAKQ PGGKVVHDPR LTWNTVEMVE DAGGIPVLCK 300
    SGHAFIKEKM RSENAVYGGE MSAHHYFREF AYADSGMIPW LLIAELVSQS 350
    GRSLADLVEA RMQKFPCSGE INFKVDDAKA AVARVMAHYG DQSPELDYTD 400
    GISADFGQWR FNLRSSNTEP LLRLNVETRG DAALLETRTQ EISNLLRG 448
    Length:448
    Mass (Da):48,922
    Last modified:April 8, 2008 - v1
    Checksum:i221961862CAEAB8F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF204145 Genomic DNA. Translation: AAA27610.1.
    AM920689 Genomic DNA. Translation: CAP53096.1.
    PIRiA43304.
    RefSeqiYP_001905134.1. NC_010688.1.

    Genome annotation databases

    EnsemblBacteriaiCAP53096; CAP53096; xcc-b100_3729.
    GeneIDi6325197.
    KEGGixca:xccb100_3729.
    PATRICi24087410. VBIXanCam108527_3766.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF204145 Genomic DNA. Translation: AAA27610.1 .
    AM920689 Genomic DNA. Translation: CAP53096.1 .
    PIRi A43304.
    RefSeqi YP_001905134.1. NC_010688.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 509169.xccb100_3729.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAP53096 ; CAP53096 ; xcc-b100_3729 .
    GeneIDi 6325197.
    KEGGi xca:xccb100_3729.
    PATRICi 24087410. VBIXanCam108527_3766.

    Phylogenomic databases

    eggNOGi COG1109.
    KOi K15778.
    OMAi VVGCDIR.
    OrthoDBi EOG6W9X55.

    Enzyme and pathway databases

    UniPathwayi UPA00126 ; UER00424 .
    BioCyci XCAM509169:GHW4-3815-MONOMER.

    Family and domain databases

    Gene3Di 3.30.310.50. 1 hit.
    3.40.120.10. 3 hits.
    InterProi IPR005844. A-D-PHexomutase_a/b/a-I.
    IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
    IPR005845. A-D-PHexomutase_a/b/a-II.
    IPR005846. A-D-PHexomutase_a/b/a-III.
    IPR005843. A-D-PHexomutase_C.
    IPR016066. A-D-PHexomutase_CS.
    IPR005841. Alpha-D-phosphohexomutase_SF.
    [Graphical view ]
    Pfami PF02878. PGM_PMM_I. 1 hit.
    PF02879. PGM_PMM_II. 1 hit.
    PF02880. PGM_PMM_III. 1 hit.
    PF00408. PGM_PMM_IV. 1 hit.
    [Graphical view ]
    PRINTSi PR00509. PGMPMM.
    SUPFAMi SSF53738. SSF53738. 3 hits.
    SSF55957. SSF55957. 1 hit.
    PROSITEi PS00710. PGM_PMM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetics of xanthan production in Xanthomonas campestris: the xanA and xanB genes are involved in UDP-glucose and GDP-mannose biosynthesis."
      Koeplin R., Arnold W., Hoette B., Simon R., Wang G., Puehler A.
      J. Bacteriol. 174:191-199(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome of Xanthomonas campestris pv. campestris B100 and its use for the reconstruction of metabolic pathways involved in xanthan biosynthesis."
      Vorhoelter F.-J., Schneiker S., Goesmann A., Krause L., Bekel T., Kaiser O., Linke B., Patschkowski T., Rueckert C., Schmid J., Sidhu V.K., Sieber V., Tauch A., Watt S.A., Weisshaar B., Becker A., Niehaus K., Puehler A.
      J. Biotechnol. 134:33-45(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: B100.

    Entry informationi

    Entry nameiXANA_XANCB
    AccessioniPrimary (citable) accession number: B0RVK5
    Secondary accession number(s): P29955
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3