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B0RUZ7

- 3HAO_XANCB

UniProt

B0RUZ7 - 3HAO_XANCB

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Protein
3-hydroxyanthranilate 3,4-dioxygenase
Gene
nbaC, xcc-b100_2705
Organism
Xanthomonas campestris pv. campestris (strain B100)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Binds 2 Fe2+ ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441Dioxygen By similarity
Metal bindingi48 – 481Iron 1; catalytic By similarity
Metal bindingi54 – 541Iron 1; catalytic By similarity
Binding sitei54 – 541Substrate By similarity
Metal bindingi92 – 921Iron 1; catalytic By similarity
Binding sitei96 – 961Substrate By similarity
Binding sitei106 – 1061Substrate By similarity
Metal bindingi121 – 1211Iron 2 By similarity
Metal bindingi124 – 1241Iron 2 By similarity
Metal bindingi158 – 1581Iron 2 By similarity
Metal bindingi161 – 1611Iron 2 By similarity

GO - Molecular functioni

  1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
  2. ferrous iron binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  4. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciXCAM509169:GHW4-2765-MONOMER.
UniPathwayiUPA00253; UER00330.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenase (EC:1.13.11.6)
Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name:
3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name:
HAD
Gene namesi
Name:nbaC
Ordered Locus Names:xcc-b100_2705
OrganismiXanthomonas campestris pv. campestris (strain B100)
Taxonomic identifieri509169 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000001188: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1761763-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation
PRO_1000134551Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi509169.xccb100_2705.

Structurei

3D structure databases

ProteinModelPortaliB0RUZ7.

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-HAO family.

Phylogenomic databases

eggNOGiNOG77058.
KOiK00452.
OMAiHINQTPE.
OrthoDBiEOG6PW234.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_00825. 3_HAO.
InterProiIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

Sequencei

Sequence statusi: Complete.

B0RUZ7-1 [UniParc]FASTAAdd to Basket

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MLVPPINLHA WVEQHRHLLK PPVGNKCIQQ DGFIIMIVGG PNARTDYHYD    50
EGPEWFFQLE GEMVLKVQDD GTARDIPIRA GEIFLLPPKV PHSPQRAAGS 100
IGLVIERERL PHEQDGLQWY CPQCNHKLYE AMFPLENIET DFPPVFDHFY 150
RSLALRTCMQ CGHVHPAPER YAAIEA 176
Length:176
Mass (Da):20,172
Last modified:April 8, 2008 - v1
Checksum:i3C3D78418C8458D4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM920689 Genomic DNA. Translation: CAP52066.1.
RefSeqiYP_001904110.1. NC_010688.1.

Genome annotation databases

EnsemblBacteriaiCAP52066; CAP52066; xcc-b100_2705.
GeneIDi6322736.
KEGGixca:xccb100_2705.
PATRICi24085325. VBIXanCam108527_2743.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM920689 Genomic DNA. Translation: CAP52066.1 .
RefSeqi YP_001904110.1. NC_010688.1.

3D structure databases

ProteinModelPortali B0RUZ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 509169.xccb100_2705.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAP52066 ; CAP52066 ; xcc-b100_2705 .
GeneIDi 6322736.
KEGGi xca:xccb100_2705.
PATRICi 24085325. VBIXanCam108527_2743.

Phylogenomic databases

eggNOGi NOG77058.
KOi K00452.
OMAi HINQTPE.
OrthoDBi EOG6PW234.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00330 .
BioCyci XCAM509169:GHW4-2765-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
HAMAPi MF_00825. 3_HAO.
InterProi IPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR15497. PTHR15497. 1 hit.
Pfami PF06052. 3-HAO. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Xanthomonas campestris pv. campestris B100 and its use for the reconstruction of metabolic pathways involved in xanthan biosynthesis."
    Vorhoelter F.-J., Schneiker S., Goesmann A., Krause L., Bekel T., Kaiser O., Linke B., Patschkowski T., Rueckert C., Schmid J., Sidhu V.K., Sieber V., Tauch A., Watt S.A., Weisshaar B., Becker A., Niehaus K., Puehler A.
    J. Biotechnol. 134:33-45(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B100.

Entry informationi

Entry namei3HAO_XANCB
AccessioniPrimary (citable) accession number: B0RUZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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