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B0RU49

- MDH_XANCB

UniProt

B0RU49 - MDH_XANCB

Protein

Malate dehydrogenase

Gene

mdh

Organism
Xanthomonas campestris pv. campestris (strain B100)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei94 – 941SubstrateUniRule annotation
    Binding sitei100 – 1001SubstrateUniRule annotation
    Binding sitei107 – 1071NADUniRule annotation
    Binding sitei114 – 1141NADUniRule annotation
    Binding sitei133 – 1331SubstrateUniRule annotation
    Binding sitei164 – 1641SubstrateUniRule annotation
    Active sitei189 – 1891Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 177NADUniRule annotation
    Nucleotide bindingi131 – 1333NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciXCAM509169:GHW4-3504-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:xcc-b100_3426
    OrganismiXanthomonas campestris pv. campestris (strain B100)
    Taxonomic identifieri509169 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
    ProteomesiUP000001188: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 328328Malate dehydrogenasePRO_1000191632Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi509169.xccb100_3426.

    Structurei

    3D structure databases

    ProteinModelPortaliB0RU49.
    SMRiB0RU49. Positions 2-328.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    KOiK00024.
    OMAiNCLIASK.
    OrthoDBiEOG6PP9Q2.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_01517. Malate_dehydrog_2.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23382. PTHR23382. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B0RU49-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKAPVRVAVT GAAGQIGYAL LFRIASGEML GKDQPVILQL LELSNEKAQA    50
    ALKGVMMELE DCAFPLLAGM VGTDDAEVAF KDIDVALLVG ARPRGPGMER 100
    KDLLLENAKI FTAQGAALNK VAKRDVKVLV VGNPANTNAY IAMESAPDLN 150
    PKNFTAMLRL DHNRALSQLS LKLGKPVGGI EKLVVWGNHS PTMYPDYRFA 200
    TSDGASIGDA INDQEWNAGT FIPTVGKRGA AIIEARGLSS AASAANAAID 250
    HVRDWVLGSN GKWVTMGVPS DGSYGIPEGV IFGFPVTTEN GQYTLVKDLP 300
    IDDFSQKYID KTLAELEEER SGVSHLLG 328
    Length:328
    Mass (Da):34,936
    Last modified:April 8, 2008 - v1
    Checksum:i0AEBD8B1F6F38631
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM920689 Genomic DNA. Translation: CAP52791.1.
    RefSeqiYP_001904831.1. NC_010688.1.

    Genome annotation databases

    EnsemblBacteriaiCAP52791; CAP52791; xcc-b100_3426.
    GeneIDi6324634.
    KEGGixca:xccb100_3426.
    PATRICi24086774. VBIXanCam108527_3453.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM920689 Genomic DNA. Translation: CAP52791.1 .
    RefSeqi YP_001904831.1. NC_010688.1.

    3D structure databases

    ProteinModelPortali B0RU49.
    SMRi B0RU49. Positions 2-328.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 509169.xccb100_3426.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAP52791 ; CAP52791 ; xcc-b100_3426 .
    GeneIDi 6324634.
    KEGGi xca:xccb100_3426.
    PATRICi 24086774. VBIXanCam108527_3453.

    Phylogenomic databases

    eggNOGi COG0039.
    KOi K00024.
    OMAi NCLIASK.
    OrthoDBi EOG6PP9Q2.

    Enzyme and pathway databases

    BioCyci XCAM509169:GHW4-3504-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_01517. Malate_dehydrog_2.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23382. PTHR23382. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Xanthomonas campestris pv. campestris B100 and its use for the reconstruction of metabolic pathways involved in xanthan biosynthesis."
      Vorhoelter F.-J., Schneiker S., Goesmann A., Krause L., Bekel T., Kaiser O., Linke B., Patschkowski T., Rueckert C., Schmid J., Sidhu V.K., Sieber V., Tauch A., Watt S.A., Weisshaar B., Becker A., Niehaus K., Puehler A.
      J. Biotechnol. 134:33-45(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: B100.

    Entry informationi

    Entry nameiMDH_XANCB
    AccessioniPrimary (citable) accession number: B0RU49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3