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Protein

Malate dehydrogenase

Gene

mdh

Organism
Xanthomonas campestris pv. campestris (strain B100)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei94SubstrateUniRule annotation1
Binding sitei100SubstrateUniRule annotation1
Binding sitei107NADUniRule annotation1
Binding sitei114NADUniRule annotation1
Binding sitei133SubstrateUniRule annotation1
Binding sitei164SubstrateUniRule annotation1
Active sitei189Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 17NADUniRule annotation7
Nucleotide bindingi131 – 133NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:xcc-b100_3426
OrganismiXanthomonas campestris pv. campestris (strain B100)
Taxonomic identifieri509169 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000001188 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001916321 – 328Malate dehydrogenaseAdd BLAST328

Proteomic databases

PRIDEiB0RU49

Structurei

3D structure databases

ProteinModelPortaliB0RU49
SMRiB0RU49
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

KOiK00024
OMAiRPRTKGM

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_01517 Malate_dehydrog_2, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR010945 Malate_DH_type2
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23382 PTHR23382, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01759 MalateDH-SF1, 1 hit

Sequencei

Sequence statusi: Complete.

B0RU49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAPVRVAVT GAAGQIGYAL LFRIASGEML GKDQPVILQL LELSNEKAQA
60 70 80 90 100
ALKGVMMELE DCAFPLLAGM VGTDDAEVAF KDIDVALLVG ARPRGPGMER
110 120 130 140 150
KDLLLENAKI FTAQGAALNK VAKRDVKVLV VGNPANTNAY IAMESAPDLN
160 170 180 190 200
PKNFTAMLRL DHNRALSQLS LKLGKPVGGI EKLVVWGNHS PTMYPDYRFA
210 220 230 240 250
TSDGASIGDA INDQEWNAGT FIPTVGKRGA AIIEARGLSS AASAANAAID
260 270 280 290 300
HVRDWVLGSN GKWVTMGVPS DGSYGIPEGV IFGFPVTTEN GQYTLVKDLP
310 320
IDDFSQKYID KTLAELEEER SGVSHLLG
Length:328
Mass (Da):34,936
Last modified:April 8, 2008 - v1
Checksum:i0AEBD8B1F6F38631
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM920689 Genomic DNA Translation: CAP52791.1

Genome annotation databases

EnsemblBacteriaiCAP52791; CAP52791; xcc-b100_3426
KEGGixca:xcc-b100_3426

Similar proteinsi

Entry informationi

Entry nameiMDH_XANCB
AccessioniPrimary (citable) accession number: B0RU49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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