B0RSL5 (HIS8_XANCB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histidinol-phosphate aminotransferase
EC=2.6.1.9

Alternative name(s):
Imidazole acetol-phosphate transaminase

Gene names

Name:	hisC
Ordered Locus Names:	xcc-b100_2097

Organism

Xanthomonas campestris pv. campestris (strain B100) [Complete proteome] [HAMAP]

Taxonomic identifier

509169 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Histidinol-phosphate aminotransferase HAMAP MF_01023		PRO_1000135431
Amino acid modifications
	Modified residue	218	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0RSL5 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: EB3204F1A3879D92	FASTA	362	38,356
	10 20 30 40 50 60 MSTASVMDLV RDDLRAFAGY ASARTSALQG DVWLNANESA WGNPADPDAS TRRYPDPQPK 70 80 90 100 110 120 GLRAALAQLY GCAPEQLLIG RGSDEAIDLL VRGLCVPERD AVVVTPPVFG MYAVCARLQN 130 140 150 160 170 180 APLVEVPLVD GADGLHADVP VIVQAALDAK AKLVFLCSPS NPAGSAIPLA EIEVALQALQ 190 200 210 220 230 240 GKAVVVVDEA YGEFSDVPSA IGLLARYDNL AVLRTLSKAH ALAAARIGSL IANAELIALL 250 260 270 280 290 300 RRCQAPYPVP TPCAVMAEQA LSAPALAVTQ RRVTEIRAER ARLHAALVQV AGVRQVYPSQ 310 320 330 340 350 360 GNFLLVRFDD AEAAFQALLE AGVVVRDQRA VPRLSDALRI TIGTPEQNDR VLGALQRKQE AA

References

[1]

"The genome of Xanthomonas campestris pv. campestris B100 and its use for the reconstruction of metabolic pathways involved in xanthan biosynthesis." Vorhoelter F.-J., Schneiker S., Goesmann A., Krause L., Bekel T., Kaiser O., Linke B., Patschkowski T., Rueckert C., Schmid J., Sidhu V.K., Sieber V., Tauch A., Watt S.A., Weisshaar B., Becker A., Niehaus K., Puehler A. J. Biotechnol. 134:33-45(2008) [PubMed: 18304669] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: B100.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM920689 Genomic DNA. Translation: CAP51450.1.
RefSeq	YP_001903502.1. NC_010688.1.
3D structure databases
ProteinModelPortal	B0RSL5.
ModBase	Search...
Protein-protein interaction databases
STRING	B0RSL5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6322207.
GenomeReviews	Gene locus xcc-b100_2097 in contig AM920689_GR.
PATRIC	24084089. VBIXanCam108527_2133.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG646350.
OMA	RDQRAVP.
ProtClustDB	PRK04781.
Enzyme and pathway databases
BioCyc	XCAM487884:XCC-B100_2097-MONOMER.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01141. HisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS8_XANCB

Accession

Primary (citable) accession number: B0RSL5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	April 8, 2008
Last modified:	January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program