B0RIE3 (ARAA_CLAMS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-arabinose isomerase
EC=5.3.1.4

Gene names

Name:	araA
Ordered Locus Names:	CMS0133

Organism

Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / JCM 9667) [Complete proteome] [HAMAP]

Taxonomic identifier

31964 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Microbacteriaceae › Clavibacter

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity. HAMAP MF_00519
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity. HAMAP MF_00519
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Sequence similarities	Belongs to the arabinose isomerase family.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW fucose metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: EC L-fucose isomerase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 505	505	L-arabinose isomerase HAMAP MF_00519		PRO_1000081674
Sites
	Metal binding	310	1	Manganese By similarity
	Metal binding	337	1	Manganese By similarity
	Metal binding	354	1	Manganese By similarity
	Metal binding	453	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0RIE3 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 2DE6AEDB72DBCED2	FASTA	505	55,615
	10 20 30 40 50 60 MSRITTSLDH YEVWFLTGSQ NLYGEETLQQ VAEQSQEIAR QLEEASDIPV RVVWKPVLKD 70 80 90 100 110 120 SDSIRRMALE ANASDRTIGL IAWMHTFSPA KMWIQGLDAL QKPFLHLHTQ ANVALPWSSI 130 140 150 160 170 180 DMDFMNLNQA AHGDREFGYI QSRLGVVRKT VVGHVSTESV RDSIGTWMRA AAGWAAVHEL 190 200 210 220 230 240 KVARFGDNMR NVAVTEGDKT EAELKFGVSV NTWGVNDLVE RVDAATDAEI DALVDEYERL 250 260 270 280 290 300 YDIAPELQRG GERHESLRYG AAIEVGLRSF LEEGGFGAFT TSFEDLGGLR QLPGLAVQRL 310 320 330 340 350 360 MAEGYGFGAE GDWKTAVLIR AAKVMGSGLP GGASLMEDYT YHLVPGEEKI LGAHMLEICP 370 380 390 400 410 420 TLTTGRPSLE IHPLGIGGRE DPVRLVFDTD PGPAVVVAMS DMRERFRIVA NVVEVVPLDE 430 440 450 460 470 480 PLPNLPVARA VWKPAPDLAT SAAAWLTAGA AHHTVMSTQV GVEVFEDFAE IARTELLVID 490 500 EDTTLKGFTK EVRWNQAYHR LAQGL

References

[1]

"Genome of the actinomycete plant pathogen Clavibacter michiganensis subsp. sepedonicus suggests recent niche adaptation." Bentley S.D., Corton C., Brown S.E., Barron A., Clark L., Doggett J., Harris B., Ormond D., Quail M.A., May G., Francis D., Knudson D., Parkhill J., Ishimaru C.A. J. Bacteriol. 190:2150-2160(2008) [PubMed: 18192393] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33113 / JCM 9667.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM849034 Genomic DNA. Translation: CAQ00257.1.
RefSeq	YP_001708921.1. NC_010407.1.
3D structure databases
ProteinModelPortal	B0RIE3.
SMR	B0RIE3. Positions 6-501.
ModBase	Search...
Protein-protein interaction databases
STRING	B0RIE3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6156123.
GenomeReviews	Gene locus CMS0133 in contig AM849034_GR.
KEGG	cms:CMS_0133.
PATRIC	21457216. VBIClaMic4666_0184.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG297198.
OMA	EVCPTIA.
ProtClustDB	PRK02929.
Enzyme and pathway databases
BioCyc	CMIC31964:CMS0133-MONOMER.
Family and domain databases
HAMAP	MF_00519. Arabinose_Isome. [Tree]
InterPro	IPR024664. Ara_Isoase_C. IPR004216. Fuc/Ara_isomerase_C. IPR009015. Fucose_isomerase_N/cen. IPR003762. Lara_isomerase. [Graphical view]
KO	K01804.
Pfam	PF11762. Arabinose_Iso_C. 1 hit. PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF50443. Fuc_isomerase_C. 1 hit. SSF53743. Fuc_isomerase_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARAA_CLAMS

Accession

Primary (citable) accession number: B0RIE3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	April 8, 2008
Last modified:	January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program