Reviewed, UniProtKB/Swiss-Prot B0RHD0 (ARGC_CLAMS)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	CMS1231

Organism

Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / JCM 9667) [Complete proteome] [HAMAP]

Taxonomic identifier

31964 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Microbacteriaceae › Clavibacter

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000076728
Sites
	Active site	152	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0RHD0-1 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: E6574AFB15A3DB36	FASTA	349	36,005
	10 20 30 40 50 60 MSFSVAVAGA SGYAGGELLR LLADHPRLEV QTLTAFQNAG ERLREVHPHL TSYADRTFVE 70 80 90 100 110 120 TTAEQLAGHD VVFLALPHGK SGAITAELDD QTLVVDCGAD HRLVDEAAWD AFYGGDFAGA 130 140 150 160 170 180 WPYGLPELLH AEEGGTQRTR LSGVKRIAVP GCNVTAITLG LQPGIRAGVI EPEDVVAVLA 190 200 210 220 230 240 VGPSGAGRSL RTNLLASEIL GSASAYAVGG THRHTPEIRQ NLETAGGGHV SVSFTPVLVP 250 260 270 280 290 300 MARGILATAT ARLAPGFSAH DVRAAWELAY ADEPFVHLLP EGTFPNVSDV TGSNTALVGL 310 320 330 340 AIDEAAGRVV TVTAIDNLVK GTAGAAIQSA NIALGLPEAM GLPVNGVAP

References

[1]

"Genome of the actinomycete plant pathogen Clavibacter michiganensis subsp. sepedonicus suggests recent niche adaptation." Bentley S.D., Corton C., Brown S.E., Barron A., Clark L., Doggett J., Harris B., Ormond D., Quail M.A., May G., Francis D., Knudson D., Parkhill J., Ishimaru C.A. J. Bacteriol. 190:2150-2160(2008) [PubMed: 18192393] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM849034 Genomic DNA. Translation: CAQ01347.1.
RefSeq	YP_001709969.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6158866.
GenomeReviews	Gene locus CMS1231 in contig AM849034_GR.
KEGG	cms:CMS_1231.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	B0RHD0. VCRIAVH.
Family and domain databases
HAMAP	MF_00150. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_CLAMS

Accession

Primary (citable) accession number: B0RHD0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	April 8, 2008
Last modified:	June 16, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)