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B0RGG4 (THIM_CLAMS) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:CMS1103
OrganismClavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1) (Corynebacterium sepedonicum) [Complete proteome] [HAMAP]
Taxonomic identifier31964 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeClavibacter

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 275275Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000383836

Sites

Binding site571Substrate; via amide nitrogen By similarity
Binding site1321ATP By similarity
Binding site1781ATP By similarity
Binding site2051Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
B0RGG4 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: C7B9DC64A70A4AFA

FASTA27527,673
        10         20         30         40         50         60 
MSALRPSTGT ITRGTPTSAD LLLQLRERQP LVQCITNAVV TGFTANVLLA LGAAPAMTDV 

        70         80         90        100        110        120 
PTESGPFARI ASGVLINLGT PHAEQREAAV EAAHAARDAG TPWVLDPVAV GALPVRTRLA 

       130        140        150        160        170        180 
HELVALSPTI VRGNASEIIA LATGGAGGRG VDATDEVEAA LDAASLLART YGTVVAVSGA 

       190        200        210        220        230        240 
VDHITDGHRL VRVHTGDAWL TKVTGGGCAL GAVMTAFAST DPDPLRAAVA ATSGYTIAAD 

       250        260        270 
IAAEGARGPG SFAVGLLDAL DAVTPELVAQ SERLS 

« Hide

References

[1]"Genome of the actinomycete plant pathogen Clavibacter michiganensis subsp. sepedonicus suggests recent niche adaptation."
Bentley S.D., Corton C., Brown S.E., Barron A., Clark L., Doggett J., Harris B., Ormond D., Quail M.A., May G., Francis D., Knudson D., Parkhill J., Ishimaru C.A.
J. Bacteriol. 190:2150-2160(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM849034 Genomic DNA. Translation: CAQ01221.1.
RefSeqYP_001709847.1. NC_010407.1.

3D structure databases

ProteinModelPortalB0RGG4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING31964.CMS_1103.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAQ01221; CAQ01221; CMS1103.
GeneID6159012.
KEGGcms:CMS_1103.
PATRIC21459212. VBIClaMic4666_1167.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
KOK00878.
OMAQTFTANV.

Enzyme and pathway databases

BioCycCMIC31964:GJBN-1114-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_CLAMS
AccessionPrimary (citable) accession number: B0RGG4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: April 8, 2008
Last modified: June 11, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways