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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1) (Corynebacterium sepedonicum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37SubstrateUniRule annotation1
Binding sitei119SubstrateUniRule annotation1
Binding sitei156SubstrateUniRule annotation1
Binding sitei206ATPUniRule annotation1
Binding sitei302ATP; via carbonyl oxygenUniRule annotation1
Binding sitei333ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi359 – 362ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:CMS1987
OrganismiClavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1) (Corynebacterium sepedonicum)
Taxonomic identifieri31964 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrobacteriaceaeClavibacter
Proteomesi
  • UP000001318 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000765831 – 404Phosphoglycerate kinaseAdd BLAST404

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi31964.CMS_1987

Structurei

3D structure databases

ProteinModelPortaliB0REJ2
SMRiB0REJ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 24Substrate bindingUniRule annotation3
Regioni60 – 63Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
KOiK00927
OMAiDMIFDIG
OrthoDBiPOG091H00YN

Family and domain databases

Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

B0REJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRTIDSLG DLRGRRVIVR CDLNVPLKGG VIGDDGRIRA SLGTLTGLRE
60 70 80 90 100
AGARVIVISH LGRPDGTPDE KYSLRPVAAR LGELLRADVA FADDTVGDSA
110 120 130 140 150
RAAVEALGDG DVVVLENLRF HAEETSKDET VRRGFAESIA ELGDAFVSDG
160 170 180 190 200
FGVVHRKQAS VFELAQALPS AAGSLIASEL EVLDRLTENP ERPYTVVLGG
210 220 230 240 250
SKVSDKLGVI GHLLPRVDSL LIGGGMLFTF LKAQGHEVGA SLLEEDQVET
260 270 280 290 300
VKGYLAEAEE RGVKIVLPTD VVVADGFSAD AAHEVTRADA IEGTPAGAKG
310 320 330 340 350
LGLDIGPETA DAFATIIRGS TTVFWNGPMG VFELEPFAAG TKTVADALTR
360 370 380 390 400
VEGLSVVGGG DSAAAVRALG FDDDRFGHIS TGGGASLEFL EGKRLPGLEV

LGWQ
Length:404
Mass (Da):42,215
Last modified:April 8, 2008 - v1
Checksum:iDB4BCCE8C2659A3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM849034 Genomic DNA Translation: CAQ02084.1
RefSeqiWP_012299315.1, NZ_MZMN01000003.1

Genome annotation databases

EnsemblBacteriaiCAQ02084; CAQ02084; CMS1987
GeneIDi29470518
KEGGicms:CMS1987

Similar proteinsi

Entry informationi

Entry nameiPGK_CLAMS
AccessioniPrimary (citable) accession number: B0REJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: June 20, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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