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Protein

Isocitrate dehydrogenase [NADP]

Gene

CMS0599

Organism
Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1) (Corynebacterium sepedonicum)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei77SubstrateUniRule annotation1
Binding sitei82NADPUniRule annotation1
Binding sitei109SubstrateUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Sitei139Critical for catalysisUniRule annotation1
Sitei211Critical for catalysisUniRule annotation1
Metal bindingi251Magnesium or manganeseUniRule annotation1
Binding sitei259NADPUniRule annotation1
Metal bindingi274Magnesium or manganeseUniRule annotation1
Binding sitei327NADP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi75 – 77NADPUniRule annotation3
Nucleotide bindingi309 – 314NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processTricarboxylic acid cycleUniRule annotation
LigandMagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:CMS0599Imported
OrganismiClavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1) (Corynebacterium sepedonicum)Imported
Taxonomic identifieri31964 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrobacteriaceaeClavibacter
Proteomesi
  • UP000001318 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi31964.CMS_0599

Structurei

3D structure databases

ProteinModelPortaliB0RDS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni94 – 100Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5N Bacteria
COG0538 LUCA
KOiK00031
OMAiAMGMYNQ
OrthoDBiPOG091H0JP0

Family and domain databases

InterProiView protein in InterPro
IPR019818 IsoCit/isopropylmalate_DH_CS
IPR004790 Isocitrate_DH_NADP
IPR024084 IsoPropMal-DH-like_dom
PANTHERiPTHR11822 PTHR11822, 1 hit
PfamiView protein in Pfam
PF00180 Iso_dh, 1 hit
PIRSFiPIRSF000108 IDH_NADP, 1 hit
SMARTiView protein in SMART
SM01329 Iso_dh, 1 hit
TIGRFAMsiTIGR00127 nadp_idh_euk, 1 hit
PROSITEiView protein in PROSITE
PS00470 IDH_IMDH, 1 hit

Sequencei

Sequence statusi: Complete.

B0RDS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKIKVEGTV VELDGDEMTR IIWQSIKDTL IHPYLDIDLE YYDLGIEKRD
60 70 80 90 100
ETDDQITIDA ANAIKKHGVG VKCATITPDE ARVEEFGLKK MWRSPNGTIR
110 120 130 140 150
NILGGTIFRE PIIISNIPRL VPGWNKPIIV GRHAFGDQYR ATDFRFEGEG
160 170 180 190 200
TLTMTFTPKD GSEPQQFEVF QSPGSGVAMG MYNLDDSIRD FARASLSYGL
210 220 230 240 250
ARNYPVYLST KNTILKAYDG RFKDLFQEVF EAEYAEQFAA AGLTYEHRLI
260 270 280 290 300
DDMVAASLKW EGGYVWACKN YDGDVQSDTV AQGFGSLGLM TSVLTTPDGK
310 320 330 340 350
VVEAEAAHGT VTRHYRQHQQ GKPTSTNPIA SIYAWTRGLA HRAKLDGNDA
360 370 380 390 400
LKTFADTLED VVITTVESGK MTKDLALLVG PDQPYQTTEE FLASLAENLQ

TRLA
Length:404
Mass (Da):44,989
Last modified:April 8, 2008 - v1
Checksum:iABE970EFB3ABB19D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM849034 Genomic DNA Translation: CAQ00719.1
RefSeqiWP_012298036.1, NZ_MZMN01000003.1

Genome annotation databases

EnsemblBacteriaiCAQ00719; CAQ00719; CMS0599
GeneIDi29470826
KEGGicms:CMS0599

Similar proteinsi

Entry informationi

Entry nameiB0RDS6_CLAMS
AccessioniPrimary (citable) accession number: B0RDS6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: April 25, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health