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B0RDS6 (B0RDS6_CLAMS) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity
Nucleotide binding309 – 3146NADP By similarity
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2511Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2741Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2591NADP By similarity
Binding site3271NADP; via amide nitrogen and carbonyl oxygen By similarity
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2111Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
B0RDS6 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: ABE970EFB3ABB19D

FASTA40444,989
        10         20         30         40         50         60 
MEKIKVEGTV VELDGDEMTR IIWQSIKDTL IHPYLDIDLE YYDLGIEKRD ETDDQITIDA 

        70         80         90        100        110        120 
ANAIKKHGVG VKCATITPDE ARVEEFGLKK MWRSPNGTIR NILGGTIFRE PIIISNIPRL 

       130        140        150        160        170        180 
VPGWNKPIIV GRHAFGDQYR ATDFRFEGEG TLTMTFTPKD GSEPQQFEVF QSPGSGVAMG 

       190        200        210        220        230        240 
MYNLDDSIRD FARASLSYGL ARNYPVYLST KNTILKAYDG RFKDLFQEVF EAEYAEQFAA 

       250        260        270        280        290        300 
AGLTYEHRLI DDMVAASLKW EGGYVWACKN YDGDVQSDTV AQGFGSLGLM TSVLTTPDGK 

       310        320        330        340        350        360 
VVEAEAAHGT VTRHYRQHQQ GKPTSTNPIA SIYAWTRGLA HRAKLDGNDA LKTFADTLED 

       370        380        390        400 
VVITTVESGK MTKDLALLVG PDQPYQTTEE FLASLAENLQ TRLA 

« Hide

References

[1]"Genome of the actinomycete plant pathogen Clavibacter michiganensis subsp. sepedonicus suggests recent niche adaptation."
Bentley S.D., Corton C., Brown S.E., Barron A., Clark L., Doggett J., Harris B., Ormond D., Quail M.A., May G., Francis D., Knudson D., Parkhill J., Ishimaru C.A.
J. Bacteriol. 190:2150-2160(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM849034 Genomic DNA. Translation: CAQ00719.1.
RefSeqYP_001709366.1. NC_010407.1.

3D structure databases

ProteinModelPortalB0RDS6.
SMRB0RDS6. Positions 2-404.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING31964.CMS_0599.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAQ00719; CAQ00719; CMS0599.
GeneID6156557.
KEGGcms:CMS_0599.
PATRIC21458184. VBIClaMic4666_0659.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0538.
KOK00031.
OMAKNTIMKV.
OrthoDBEOG628F3X.

Enzyme and pathway databases

BioCycCMIC31964:GJBN-609-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB0RDS6_CLAMS
AccessionPrimary (citable) accession number: B0RDS6
Entry history
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: July 9, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)