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Protein

Alanine racemase

Gene

alr*

Organism
Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1) (Corynebacterium sepedonicum)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei48 – 481Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei146 – 1461SubstrateUniRule annotation
Active sitei276 – 2761Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei324 – 3241Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
  2. threonylcarbamoyladenosine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCMIC31964:GJBN-529-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotationSAAS annotation (EC:5.1.1.1UniRule annotationSAAS annotation)
Gene namesi
Name:alr*Imported
Ordered Locus Names:CMS0521Imported
OrganismiClavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1) (Corynebacterium sepedonicum)Imported
Taxonomic identifieri31964 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeClavibacter
ProteomesiUP000001318: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei48 – 481N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi31964.CMS_0521.

Structurei

3D structure databases

ProteinModelPortaliB0RD41.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0802.
KOiK01775.
OMAiITMDQLM.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR027417. P-loop_NTPase.
IPR029066. PLP-binding_barrel.
IPR003442. T6A_TsaE.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PF02367. UPF0079. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
TIGR00150. T6A_YjeE. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0RD41-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEPASAPAS AGPVAPGRRA VIDLDAIRHN VRTLAALAAP ARTMVAVKAD
60 70 80 90 100
AYGHGALQVA RAALESGAES LAVLDVASAV ELRRAGIDAR LLAWLHGVDT
110 120 130 140 150
DFRVAVEEEI DLGVSALWEL KRIAAAGRAT GIRARVHLKA DTGLSRNGAT
160 170 180 190 200
PELWPDLVRA AVAADSAGEL TLHALWSHLA DASPEDDDAA LARFREAVRV
210 220 230 240 250
AEELGARPVE KHLAASSAGI RLPAARFDMV RFGIAVYGIS PFDDRSGRDL
260 270 280 290 300
GLIPAMTLEA DVVSVKRVEA GHGVSYGLDH RTAGPSTLVL VPLGYADGIP
310 320 330 340 350
RIAAPRASVL LNGRRFPVAG RIAMDQLVLD VGDLPVEVGD TAVILGPGDR
360 370 380 390 400
GEPTAEEWAG WAETIGDEIV TRVGPRVDRV HLHERADADD PDGGGAAANG
410 420 430 440 450
ATAEVLSDEL VPVATTDDME ELGRAVAREL GAGDLVVLSG PLGAGKTTFT
460 470 480 490 500
RGLGAGLGVR GPVTSPTFVL ARTHPSLVDG PPLVHVDAYR LADARELDDL
510 520 530 540 550
DIDFARSVVV VEWGEGKLDG VAEEWWELAI ARPTGAGDAD PDAADGGHDG
560 570
AHDASDPDAA PEEPRTVRIR RLRARPRA
Length:578
Mass (Da):60,399
Last modified:April 8, 2008 - v1
Checksum:iC9CA589B45C5123E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM849034 Genomic DNA. Translation: CAQ00640.1.
RefSeqiYP_001709292.1. NC_010407.1.

Genome annotation databases

EnsemblBacteriaiCAQ00640; CAQ00640; CMS0521.
GeneIDi6158594.
KEGGicms:CMS_0521.
PATRICi21458023. VBIClaMic4666_0580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM849034 Genomic DNA. Translation: CAQ00640.1.
RefSeqiYP_001709292.1. NC_010407.1.

3D structure databases

ProteinModelPortaliB0RD41.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi31964.CMS_0521.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAQ00640; CAQ00640; CMS0521.
GeneIDi6158594.
KEGGicms:CMS_0521.
PATRICi21458023. VBIClaMic4666_0580.

Phylogenomic databases

eggNOGiCOG0802.
KOiK01775.
OMAiITMDQLM.
OrthoDBiEOG6PP9NJ.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciCMIC31964:GJBN-529-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR027417. P-loop_NTPase.
IPR029066. PLP-binding_barrel.
IPR003442. T6A_TsaE.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PF02367. UPF0079. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
TIGR00150. T6A_YjeE. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome of the actinomycete plant pathogen Clavibacter michiganensis subsp. sepedonicus suggests recent niche adaptation."
    Bentley S.D., Corton C., Brown S.E., Barron A., Clark L., Doggett J., Harris B., Ormond D., Quail M.A., May G., Francis D., Knudson D., Parkhill J., Ishimaru C.A.
    J. Bacteriol. 190:2150-2160(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1Imported.

Entry informationi

Entry nameiB0RD41_CLAMS
AccessioniPrimary (citable) accession number: B0RD41
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: February 4, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.