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Protein

Alanine racemase

Gene

alr

Organism
Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1) (Corynebacterium sepedonicum)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr), Alanine racemase (alr*)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei45Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei143SubstrateUniRule annotation1
Active sitei273Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei321Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:CMS0520Imported
OrganismiClavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1) (Corynebacterium sepedonicum)Imported
Taxonomic identifieri31964 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrobacteriaceaeClavibacter
Proteomesi
  • UP000001318 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi31964.CMS_0520

Structurei

3D structure databases

ProteinModelPortaliB0RD40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
KOiK01775
OMAiWRGPILL
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.102 hits
3.20.20.101 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

B0RD40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDEATVQVP AALRREARID LGAISTNVRT LRAAAGAPLV MAVVKADGYG
60 70 80 90 100
HGAVASARAA LAGGADRLGV VDIREALALR AAGIEAPILT WMHAPYADFA
110 120 130 140 150
TAIEAGIDLG LNSLRQVREA AEAARRVGRT AEVHLKVDTG LGRNGVTPAE
160 170 180 190 200
WPGVVAEVAA LVAEGRIHLG GVFSHLANAG EDEDRAQVRA FHEAVDVVRA
210 220 230 240 250
AGLEPGIRHL AATAGALRVP EARLDMVRLG IGIYGISPLD GVTSADLGLV
260 270 280 290 300
PAMTLVGSVV AVKRVPADTG VSYGYTYRTT SATTLALVSL GFADGVPRLA
310 320 330 340 350
SNRAPVAIHG ARFRVSGRIA MDQFVVDVGD GVVDGRPVAV GDDAVLFGDP
360 370 380
ATGAPSVEEW AEATGTIGYE IVARVAGRVT RRHSA
Length:385
Mass (Da):39,664
Last modified:April 8, 2008 - v1
Checksum:i989F4D16F3258B92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM849034 Genomic DNA Translation: CAQ00639.1
RefSeqiWP_012297964.1, NZ_MZMN01000003.1

Genome annotation databases

EnsemblBacteriaiCAQ00639; CAQ00639; CMS0520
GeneIDi29469865
KEGGicms:CMS0520

Similar proteinsi

Entry informationi

Entry nameiB0RD40_CLAMS
AccessioniPrimary (citable) accession number: B0RD40
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: April 25, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported