B0RD37 (COAA_CLAMS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate kinase
EC=2.7.1.33

Alternative name(s):
Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	CMS0517

Organism

Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / JCM 9667) [Complete proteome] [HAMAP]

Taxonomic identifier

31964 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Microbacteriaceae › Clavibacter

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm By similarity HAMAP MF_00215.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 319	319	Pantothenate kinase HAMAP MF_00215		PRO_1000078054
Regions
	Nucleotide binding	101 – 108	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	B0RD37 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: DA8E5D132DF13CC4	FASTA	319	35,632
	10 20 30 40 50 60 MADTATGSPT SHGHVSPFVE IARADWAALA PATHLPLRET ELVQLRGIGD RLDMREVEDV 70 80 90 100 110 120 YLPLSRLLNL YVTGTKKLHR DTSAFLGERA KSTPFIIGVA GSVAVGKSTV ARLLREMLAR 130 140 150 160 170 180 WDDTPRVELV TTDGFLHPNA ELERRGLMER KGFPESYDRR ALLRFVTQVK SGVPEVRAPF 190 200 210 220 230 240 YSHLAYDIVP GAEVVVRQPD VLIIEGLNVL QPAASGAKLA VSDLFDFSIY VDARTHDIAQ 250 260 270 280 290 300 WYEERFLSLQ RGAFSNPRSY FHRYAELSPA EAVARARGIW SAINEPNLEQ NIRPTRSRAT 310 LVLRKDADHS VANVLLRKL

References

[1]

"Genome of the actinomycete plant pathogen Clavibacter michiganensis subsp. sepedonicus suggests recent niche adaptation." Bentley S.D., Corton C., Brown S.E., Barron A., Clark L., Doggett J., Harris B., Ormond D., Quail M.A., May G., Francis D., Knudson D., Parkhill J., Ishimaru C.A. J. Bacteriol. 190:2150-2160(2008) [PubMed: 18192393] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33113 / JCM 9667.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM849034 Genomic DNA. Translation: CAQ00636.1.
RefSeq	YP_001709288.1. NC_010407.1.
3D structure databases
ProteinModelPortal	B0RD37.
SMR	B0RD37. Positions 16-319.
ModBase	Search...
Protein-protein interaction databases
STRING	B0RD37.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6156480.
GenomeReviews	Gene locus CMS0517 in contig AM849034_GR.
KEGG	cms:CMS_0517.
PATRIC	21458015. VBIClaMic4666_0576.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG732538.
OMA	EVYLPLS.
ProtClustDB	PRK05439.
Enzyme and pathway databases
BioCyc	CMIC31964:CMS0517-MONOMER.
Family and domain databases
HAMAP	MF_00215. Pantothen_kinase_1. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK/URK. [Graphical view]
KO	K00867.
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. PanK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_CLAMS

Accession

Primary (citable) accession number: B0RD37

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	April 8, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program