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Protein

dCTP deaminase, dUMP-forming

Gene

dcd

Organism
Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1) (Corynebacterium sepedonicum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.UniRule annotation

Catalytic activityi

dCTP + 2 H2O = dUMP + diphosphate + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. dCTP deaminase, dUMP-forming (dcd)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP, the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei116 – 117Important for bifunctional activityUniRule annotation2
Binding sitei119dCTPUniRule annotation1
Active sitei129Proton donor/acceptorUniRule annotation1
Binding sitei148dCTPUniRule annotation1
Binding sitei162dCTPUniRule annotation1
Binding sitei174dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi101 – 106dCTP bindingUniRule annotation6
Nucleotide bindingi127 – 129dCTP bindingUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00610; UER00667

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminase, dUMP-formingUniRule annotation (EC:3.5.4.30UniRule annotation)
Alternative name(s):
Bifunctional dCTP deaminase:dUTPaseUniRule annotation
DCD-DUTUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:CMS3030
OrganismiClavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1) (Corynebacterium sepedonicum)
Taxonomic identifieri31964 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrobacteriaceaeClavibacter
Proteomesi
  • UP000001318 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000766151 – 201dCTP deaminase, dUMP-formingAdd BLAST201

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi31964.CMS_3030

Structurei

3D structure databases

ProteinModelPortaliB0RD07
SMRiB0RD07
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DHP Bacteria
COG0717 LUCA
KOiK01494
OMAiGQLCLFR
OrthoDBiPOG091H021I

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

B0RD07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLSDRDITA ELDAGRVALD PYDPGMLQPA SIDVRIDRFF RLFDNHKYPY
60 70 80 90 100
IDPAEDQPEL TRLIEAKQGD PFILHPGEFV LGSTFEMVTL PDDVAARLEG
110 120 130 140 150
KSSLGRLGLL THSTAGFIDP GFSGHVTLEL SNVATLPIKL WPGMKIGQLC
160 170 180 190 200
FFRLSSPAEK PYGSGEYASR YQGQRGPTAS RSYLNFQHTD VTVTDAGQSG

E
Length:201
Mass (Da):22,120
Last modified:April 8, 2008 - v1
Checksum:i28516796A74F8922
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM849034 Genomic DNA Translation: CAQ03100.1
RefSeqiWP_012300245.1, NZ_MZMN01000003.1

Genome annotation databases

EnsemblBacteriaiCAQ03100; CAQ03100; CMS3030
GeneIDi29472155
KEGGicms:CMS3030

Similar proteinsi

Entry informationi

Entry nameiDCDB_CLAMS
AccessioniPrimary (citable) accession number: B0RD07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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