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Protein

Dihydrolipoyl dehydrogenase

Gene

pdhD

Organism
Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1) (Corynebacterium sepedonicum)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

GlycolysisSAAS annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein, NADUniRule annotation

Enzyme and pathway databases

BioCyciCMIC31964:GJBN-1643-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Name:pdhDImported
Ordered Locus Names:CMS1625Imported
OrganismiClavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1) (Corynebacterium sepedonicum)Imported
Taxonomic identifieri31964 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrobacteriaceaeClavibacter
Proteomesi
  • UP000001318 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi31964.CMS_1625.

Structurei

3D structure databases

ProteinModelPortaliB0RC07.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 317312FAD/NAD-binding_domInterPro annotationAdd
BLAST
Domaini337 – 445109Pyr_redox_dimInterPro annotationAdd
BLAST

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiENOG4107QN2. Bacteria.
COG1249. LUCA.
KOiK00382.
OMAiELYNYSS.
OrthoDBiPOG091H0239.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0RC07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQNFDVVV LGGGSGGYAA ALRAVQLGKT VGLVEKGKLG GTCLHRGCIP
60 70 80 90 100
TKALLHSAEV ADVSRESEKY GVIATFDGVD IAKVNAYREA IVASKYKGLQ
110 120 130 140 150
GLIKARGITV IEGEGRLTSG TTVQVGDQTI TGKSVVLATG SYSRTLPGLE
160 170 180 190 200
IGGCVITSEQ ALELDYIPKK VAILGGGVIG VEFASVWRSF GVEVQIVEAL
210 220 230 240 250
PHLVPNEEES ISKQFERAFR KRGIAFSLGV RFKSVMQHDQ GVQVALEDGT
260 270 280 290 300
TYDADLLLVA VGRGPATQGL GFEEAGVKTD RGFVLTDERL QTSVPGVYAV
310 320 330 340 350
GDIVPGLQLA HRGFQQGIFV AEEIAGNKPV VVEDINIPKV TYSDPEVASV
360 370 380 390 400
GYSEAKAVEK FGADKVSSYE YNLGGNGKSS ILGTAGSIKV VRVQDGPVVG
410 420 430 440 450
IHMIGVRVGE LIGEGQLIVN WEAYPEDVAN LVHAHPTQNE ALGEAHLALA

GTPLHAL
Length:457
Mass (Da):48,056
Last modified:April 8, 2008 - v1
Checksum:i60CE0283E3AB796E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM849034 Genomic DNA. Translation: CAQ01735.1.
RefSeqiWP_012298991.1. NC_010407.1.

Genome annotation databases

EnsemblBacteriaiCAQ01735; CAQ01735; CMS1625.
KEGGicms:CMS1625.
PATRICi21460284. VBIClaMic4666_1690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM849034 Genomic DNA. Translation: CAQ01735.1.
RefSeqiWP_012298991.1. NC_010407.1.

3D structure databases

ProteinModelPortaliB0RC07.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi31964.CMS_1625.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAQ01735; CAQ01735; CMS1625.
KEGGicms:CMS1625.
PATRICi21460284. VBIClaMic4666_1690.

Phylogenomic databases

eggNOGiENOG4107QN2. Bacteria.
COG1249. LUCA.
KOiK00382.
OMAiELYNYSS.
OrthoDBiPOG091H0239.

Enzyme and pathway databases

BioCyciCMIC31964:GJBN-1643-MONOMER.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB0RC07_CLAMS
AccessioniPrimary (citable) accession number: B0RC07
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.