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B0RBY6 (B0RBY6_CLAMS) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyruvate dehydrogenase E1 component PIRNR PIRNR000156
EC=1.2.4.1 PIRNR PIRNR000156
Gene names
Name:aceE EMBL CAQ01714.1
Ordered Locus Names:CMS1604
OrganismClavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / JCM 9667) [Complete proteome] [HAMAP] EMBL CAQ01714.1
Taxonomic identifier31964 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Microbacteriaceae › Clavibacter

Protein attributes

Sequence length923 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. PIRNR PIRNR000156

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2. PIRNR PIRNR000156

Cofactor

Thiamine pyrophosphate By similarity. PIRNR PIRNR000156

Sequences

Sequence LengthMass (Da)Tools
B0RBY6 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: C776784930A76E06

FASTA923102,783
        10         20         30         40         50         60 
MAPKTMSAHH RKRSRVTVND QDPYSVNHTD QDPEETAEWN ESLDGLVETQ GRGRARDVML 

        70         80         90        100        110        120 
SLLKRSKELH LGVPMVPTTD YINTIAPENE PDFPGDEDLE RRYRAWIRWN AAVTVHRAQR 

       130        140        150        160        170        180 
PGIAVGGHIA TYASSAALYE VGYNHFFRGQ DHPGGGDQVF VQGHASPGTY ARAFLEGRLS 

       190        200        210        220        230        240 
EHQLDGFRQE KSHEGGGLSS YPHPRLMPEF WQFPTVSMGL GPINAIYQAQ ANKYLTNRGI 

       250        260        270        280        290        300 
KDASDQQVWA FLGDGEMDEV ESRGQLQVAA NEKLDNLNFV INCNLQRLDG PVRGNGKIIQ 

       310        320        330        340        350        360 
ELESFFRGAG WNVIKVVWGR EWDDLLARDT EGALLDLMNR TPDGDYQTYK AESGAYIREN 

       370        380        390        400        410        420 
FFGRDERTAK LVEGYTDDQI WNLKRGGHDY RKVYAAFKAA SEHTGQPTVI LAKTVKGYGL 

       430        440        450        460        470        480 
GPSFEGRNAT HQMKKLTLDN LKQFRDELRV PITDAQLEKN PYLPPYYHPG QNDEAIQYMQ 

       490        500        510        520        530        540 
ERRRALGGYS PERRTKHTAI TLPDDSAYRI SKKGSGTQEI ATTMAFVRLL KDLIRSKDFG 

       550        560        570        580        590        600 
NRVVPIIPDE ARTFGIDAFF PTAKIYNPNG QHYTSVDREL LLSYKESPRG QIVHVGINEA 

       610        620        630        640        650        660 
GALAAFTNLG TTYSTQGEPL IPIYVFYSMF GFQRTGDAIW AAGDQMARGF LIGATAGRTT 

       670        680        690        700        710        720 
LTGEGLQHAD GHSLVLAQTN PAIVAYDPAY AYEIGHVVRS GLERMYGGQH EDPNVMYYLT 

       730        740        750        760        770        780 
VYNEPIIHPS EPEGVDVDGI VRGVYKLKDG WVDGPKAQLM ASGVAVPWAL EAQQLLADDW 

       790        800        810        820        830        840 
GVSADVWSVT SWGELRRDGL AAEEHNMLHP HSETRVPYLE EKLRHAEGPF VAVTDFSHAV 

       850        860        870        880        890        900 
PDQIRQFVPG DYSTLGADGF GFSDTRPAAR RFFAIDGPSM VVKTLQRLAK QGKVDQDAPK 

       910        920 
WAIDKYRLLD VNAGTTGSAG GEA

« Hide

References

[1]"Genome of the actinomycete plant pathogen Clavibacter michiganensis subsp. sepedonicus suggests recent niche adaptation."
Bentley S.D., Corton C., Brown S.E., Barron A., Clark L., Doggett J., Harris B., Ormond D., Quail M.A., May G., Francis D., Knudson D., Parkhill J., Ishimaru C.A.
J. Bacteriol. 190:2150-2160(2008) [PubMed: 18192393] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM849034 Genomic DNA. Translation: CAQ01714.1.
RefSeqYP_001710327.1. NC_010407.1.

3D structure databases

ProteinModelPortalB0RBY6.
SMRB0RBY6. Positions 79-911.
ModBaseSearch...

Protein-protein interaction databases

STRINGB0RBY6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6157399.
GenomeReviewsGene locus CMS1604 in contig AM849034_GR.
KEGGcms:CMS_1604.
PATRIC21460240. VBIClaMic4666_1669.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG289271.
OMAFRQEKSH.
ProtClustDBPRK09405.

Family and domain databases

InterProIPR004660. 2-oxoA_DH_E1.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK00163.
PANTHERPTHR11624:SF37. PTHR11624:SF37. 1 hit.
PfamPF00456. Transketolase_N. 2 hits.
[Graphical view]
PIRSFPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00759. AceE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB0RBY6_CLAMS
AccessionPrimary (citable) accession number: B0RBY6
Entry history
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info