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B0RBL3

- GSA_CLAMS

UniProt

B0RBL3 - GSA_CLAMS

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1) (Corynebacterium sepedonicum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciCMIC31964:GJBN-2831-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:CMS2838
    OrganismiClavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1) (Corynebacterium sepedonicum)
    Taxonomic identifieri31964 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeClavibacter
    ProteomesiUP000001318: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 455455Glutamate-1-semialdehyde 2,1-aminomutasePRO_1000079916Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei286 – 2861N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi31964.CMS_2838.

    Structurei

    3D structure databases

    ProteinModelPortaliB0RBL3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    KOiK01845.
    OMAiRAIKPYP.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B0RBL3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTHSQDLFDR ARDVIPGGVN SPVRAFGSVG GTPRMMVRAA GPYVTDADGV    50
    EYVDLVNSWG PAILGHARPE VVKAVQDAAA LGLGFGATTP AETELAELVT 100
    ERVRVAGVDG SPDRRPVEKL RLVSTGTEAT MTAIRLARGF TGRDLLVKFA 150
    GHYHGHSDSL LAEAGSGVAT LALPGSAGIP EAIAAQTIVV PYNDLGAVRA 200
    VFAEHGPRIA AVITEAAAAN MGVVPPLPGF TAELARIAHD NGSLLISDEV 250
    LTGFRVHPAG YWGLDNDGLA ADHPDAWTPD LVTYGKVIGG GLPVAALGGR 300
    ADVMDHLAPL GPVYQAGTLS GNPVAVAAGL TTLRLADADV YRALDIAADI 350
    LIYAVELAFD RAGLAYSVQR AGSLFSFTFG TPPEHGITDY ATVQAQETWR 400
    YPAFFHSMLD QGVSLPPSVF EAWFVSAAMD EASLDRVIRA LPAAARAAAA 450
    ATPPA 455
    Length:455
    Mass (Da):47,238
    Last modified:April 8, 2008 - v1
    Checksum:iFABFDF4DF5B275C0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM849034 Genomic DNA. Translation: CAQ02909.1.
    RefSeqiWP_012300066.1. NC_010407.1.
    YP_001711471.1. NC_010407.1.

    Genome annotation databases

    EnsemblBacteriaiCAQ02909; CAQ02909; CMS2838.
    GeneIDi6158369.
    KEGGicms:CMS_2838.
    PATRICi21462713. VBIClaMic4666_2891.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM849034 Genomic DNA. Translation: CAQ02909.1 .
    RefSeqi WP_012300066.1. NC_010407.1.
    YP_001711471.1. NC_010407.1.

    3D structure databases

    ProteinModelPortali B0RBL3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 31964.CMS_2838.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAQ02909 ; CAQ02909 ; CMS2838 .
    GeneIDi 6158369.
    KEGGi cms:CMS_2838.
    PATRICi 21462713. VBIClaMic4666_2891.

    Phylogenomic databases

    eggNOGi COG0001.
    KOi K01845.
    OMAi RAIKPYP.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci CMIC31964:GJBN-2831-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome of the actinomycete plant pathogen Clavibacter michiganensis subsp. sepedonicus suggests recent niche adaptation."
      Bentley S.D., Corton C., Brown S.E., Barron A., Clark L., Doggett J., Harris B., Ormond D., Quail M.A., May G., Francis D., Knudson D., Parkhill J., Ishimaru C.A.
      J. Bacteriol. 190:2150-2160(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1.

    Entry informationi

    Entry nameiGSA_CLAMS
    AccessioniPrimary (citable) accession number: B0RBL3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3