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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1) (Corynebacterium sepedonicum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPorphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:CMS2838
OrganismiClavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1) (Corynebacterium sepedonicum)
Taxonomic identifieri31964 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrobacteriaceaeClavibacter
Proteomesi
  • UP000001318 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000799161 – 455Glutamate-1-semialdehyde 2,1-aminomutaseAdd BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei286N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi31964.CMS_2838

Structurei

3D structure databases

ProteinModelPortaliB0RBL3
SMRiB0RBL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDM Bacteria
COG0001 LUCA
KOiK01845
OMAiWGPLIFG
OrthoDBiPOG091H04O1

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

B0RBL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHSQDLFDR ARDVIPGGVN SPVRAFGSVG GTPRMMVRAA GPYVTDADGV
60 70 80 90 100
EYVDLVNSWG PAILGHARPE VVKAVQDAAA LGLGFGATTP AETELAELVT
110 120 130 140 150
ERVRVAGVDG SPDRRPVEKL RLVSTGTEAT MTAIRLARGF TGRDLLVKFA
160 170 180 190 200
GHYHGHSDSL LAEAGSGVAT LALPGSAGIP EAIAAQTIVV PYNDLGAVRA
210 220 230 240 250
VFAEHGPRIA AVITEAAAAN MGVVPPLPGF TAELARIAHD NGSLLISDEV
260 270 280 290 300
LTGFRVHPAG YWGLDNDGLA ADHPDAWTPD LVTYGKVIGG GLPVAALGGR
310 320 330 340 350
ADVMDHLAPL GPVYQAGTLS GNPVAVAAGL TTLRLADADV YRALDIAADI
360 370 380 390 400
LIYAVELAFD RAGLAYSVQR AGSLFSFTFG TPPEHGITDY ATVQAQETWR
410 420 430 440 450
YPAFFHSMLD QGVSLPPSVF EAWFVSAAMD EASLDRVIRA LPAAARAAAA

ATPPA
Length:455
Mass (Da):47,238
Last modified:April 8, 2008 - v1
Checksum:iFABFDF4DF5B275C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM849034 Genomic DNA Translation: CAQ02909.1
RefSeqiWP_012300066.1, NZ_MZMN01000003.1

Genome annotation databases

EnsemblBacteriaiCAQ02909; CAQ02909; CMS2838
GeneIDi29471844
KEGGicms:CMS2838

Similar proteinsi

Entry informationi

Entry nameiGSA_CLAMS
AccessioniPrimary (citable) accession number: B0RBL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: April 25, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health