B0RAK2 (B0RAK2_CLAMS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Kynureninase PIRNR PIRNR038800
EC=3.7.1.3 PIRNR PIRNR038800

Gene names

Ordered Locus Names:

CMS0247

Organism

Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / JCM 9667) [Complete proteome] [HAMAP] EMBL CAQ00370.1

Taxonomic identifier

31964 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Microbacteriaceae › Clavibacter

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800
Catalytic activity	L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800 L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800
Cofactor	Pyridoxal phosphate By similarity. PIRNR PIRNR038800
Pathway	Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800 Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800
Subunit structure	Homodimer By similarity. PIRNR PIRNR038800
Sequence similarities	Belongs to the kynureninase family. PIRNR PIRNR038800

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis PIRNR PIRNR038800
Ligand	Pyridoxal phosphate PIRNR PIRNR038800
Molecular function	Hydrolase PIRNR PIRNR038800 EMBL CAQ00370.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: InterPro tryptophan catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	kynureninase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B0RAK2 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: C58BE74976874861	FASTA	410	44,383
	10 20 30 40 50 60 MTPDAPATRP IPPAAELDAR DPLARFRDLF VEADDVVAYL DGNSLGRPTR ASVDRVASFV 70 80 90 100 110 120 RDQWGGRLIR GWDEDWLAMP TRIGDDLGRV TLGAAAGQTF IGDSTTVILY KLVRAAVRAR 130 140 150 160 170 180 PGRDELVIDT DNFPTDRFVL EGVAEECGMT IRWIEVAPDA GVTPDLVAEA VGERTALVVL 190 200 210 220 230 240 SQVAYRSGFL ADVPGITHIV HDAGALVLWD TCHSVGVVPT ELDAWGVDLA VGCSYKYLDG 250 260 270 280 290 300 GPGAPAHGYV RRDLQQELRQ PIQGWMGARD VFAMGPVYEP ADGIRRFLSG TPPIVGMLAM 310 320 330 340 350 360 QDMIALIEEA GMPAIRAKSL ALTGFALDLV ERDLVPLGAR VASPRDEDRR GSHVSVDHPR 370 380 390 400 410 FRDIVGALWE EGVIPDFRAP SGLRLGLSPL TTSFREVEVG VEAIRRHLAG

References

[1]

"Genome of the actinomycete plant pathogen Clavibacter michiganensis subsp. sepedonicus suggests recent niche adaptation." Bentley S.D., Corton C., Brown S.E., Barron A., Clark L., Doggett J., Harris B., Ormond D., Quail M.A., May G., Francis D., Knudson D., Parkhill J., Ishimaru C.A. J. Bacteriol. 190:2150-2160(2008) [PubMed: 18192393] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM849034 Genomic DNA. Translation: CAQ00370.1.
RefSeq	YP_001709033.1. NC_010407.1.
3D structure databases
ProteinModelPortal	B0RAK2.
ModBase	Search...
Protein-protein interaction databases
STRING	B0RAK2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6156232.
GenomeReviews	Gene locus CMS0247 in contig AM849034_GR.
KEGG	cms:CMS_0247.
PATRIC	21457460. VBIClaMic4666_0303.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG523016.
OMA	GSPAFAY.
ProtClustDB	CLSK956672.
Family and domain databases
InterPro	IPR000192. Aminotrans_V/Cys_dSase. IPR010111. Kynureninase. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
KO	K01556.
PANTHER	PTHR14084. Kynureninase. 1 hit.
Pfam	PF00266. Aminotran_5. 1 hit. [Graphical view]
PIRSF	PIRSF038800. KYNU. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B0RAK2_CLAMS

Accession

Primary (citable) accession number: B0RAK2

Entry history

Integrated into UniProtKB/TrEMBL:	April 8, 2008
Last sequence update:	April 8, 2008
Last modified:	December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)