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Protein

Catalase-peroxidase

Gene

katG

Organism
Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei79 – 791Transition state stabilizerUniRule annotation
Active sitei83 – 831Proton acceptorUniRule annotation
Metal bindingi248 – 2481Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciHSAL478009:GJVF-2309-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:OE_5186R
Encoded oniPlasmid PHS30 Publication
OrganismiHalobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Taxonomic identifieri478009 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000001321 Componenti: Plasmid PHS3

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 720720Catalase-peroxidasePRO_0000354966Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki82 ↔ 207Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-233)UniRule annotation
Cross-linki207 ↔ 233Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-82)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiB0R9V8.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB0R9V8.
SMRiB0R9V8. Positions 12-720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0R9V8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENEDHNFGT SDWWPNQLDL EILDQNSQQV DPYGEDFDYA EAFEDLDLAA
60 70 80 90 100
VKDDLEEMMT DSKDWWPADY GHYGPLFIRM AWHSAGTYRT FDGRGGAAGG
110 120 130 140 150
RQRLPPVDSW PDNVNLDKAR RLLWPIKQKY GRKLSWGDLI ILAGNVALES
160 170 180 190 200
MGFETYGFAG GRKDDYTPDE AVDWGPEDEW ETTSGDRFDA DGSLKWPLGN
210 220 230 240 250
TVMGLIYVNP EGPNGEPDLE GSAKNIRESF GKMAMNDKET VALIAGGHTF
260 270 280 290 300
GKVHGADDPE ENVGAEPAAA PIEKQGLGWE NEFGEGKGPD TITSGIEGPW
310 320 330 340 350
NTTPTQWDMS YVDNLLEYEW EPEKGPGGAW QWTTKSGELN ESAPGVQDPT
360 370 380 390 400
DTEDVMMLTT DVALKDDPDY REVLETFQEN PREFQQSFSK AWYKLIHRDM
410 420 430 440 450
GPSERFLGPE VPEETMIWQD PLPDADYDLV DDEAVAALKS ELLESELSIP
460 470 480 490 500
QLVKTAWASA STYRDSDKRG GANGARIRLE PQRSWEVNEP EQLEAALSTY
510 520 530 540 550
EDIQAEFNDA RSDDMRVSLA DLIVLGGNAA IEQAAADAGY DVDVPFEPGR
560 570 580 590 600
TDATPEQTDV ESFEALKPKA DGFRNYLGDD AEREPEELLV DKAELLNLTA
610 620 630 640 650
DDMTVLVGGL RALGVTHGDS ELGIFTDQPG TLTNDFFTTL LDMDYEWEAA
660 670 680 690 700
SEDREVFELR DRETGDVEWT GSRVDLLFGS NTRLRAIAEV YGSDADEELF
710 720
VQDFVDTWSE VMKLDRFDLE
Length:720
Mass (Da):80,477
Last modified:April 8, 2008 - v1
Checksum:iFB88823BCD3CB2F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM774418 Genomic DNA. Translation: CAP15539.1.
RefSeqiWP_010904144.1. NC_010368.1.

Genome annotation databases

EnsemblBacteriaiCAP15539; CAP15539; OE_5186R.
GeneIDi5954764.
KEGGihsl:OE_5186R.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM774418 Genomic DNA. Translation: CAP15539.1.
RefSeqiWP_010904144.1. NC_010368.1.

3D structure databases

ProteinModelPortaliB0R9V8.
SMRiB0R9V8. Positions 12-720.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB0R9V8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAP15539; CAP15539; OE_5186R.
GeneIDi5954764.
KEGGihsl:OE_5186R.

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.

Enzyme and pathway databases

BioCyciHSAL478009:GJVF-2309-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_HALS3
AccessioniPrimary (citable) accession number: B0R9V8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: April 8, 2008
Last modified: September 7, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.