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B0R858

- DUT_HALS3

UniProt

B0R858 - DUT_HALS3

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Protein

Probable deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

dut

Organism
Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Enzyme and pathway databases

BioCyciHSAL478009:GJVF-2097-MONOMER.
UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:dutUniRule annotation
Ordered Locus Names:OE_4610R
OrganismiHalobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Taxonomic identifieri478009 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000001321: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 165165Probable deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_1000130718Add
BLAST

Proteomic databases

PRIDEiB0R858.

Interactioni

Protein-protein interaction databases

STRINGi478009.OE4610R.

Structurei

3D structure databases

ProteinModelPortaliB0R858.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0717.
HOGENOMiHOG000228599.
KOiK01520.
OMAiWDAGYEG.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00635. dUTPase_arch.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR023537. dUTPase_archaeal.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.

Sequencei

Sequence statusi: Complete.

B0R858-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYERGAFVAD HVEPVADDQI QPNGVDLTVD AVLEQTEPGR IDTDGKTIGD
60 70 80 90 100
RSPVTPTADE DSTDTTVTIQ PGTYILQYAE TITIPENHVG FVYPRSSLMR
110 120 130 140 150
NSCMLHSAVW DAGYTGRGEG LFEVHHEITI ARGARVAQLV LATGDHENTY
160
DGSYQHERTD TRPGE
Length:165
Mass (Da):18,118
Last modified:April 8, 2008 - v1
Checksum:iAA5039B5964D4F77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM774415 Genomic DNA. Translation: CAP14927.1.
RefSeqiWP_010903920.1. NC_010364.1.
YP_001690273.1. NC_010364.1.

Genome annotation databases

EnsemblBacteriaiCAP14927; CAP14927; OE_4610R.
GeneIDi5953444.
KEGGihsl:OE4610R.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM774415 Genomic DNA. Translation: CAP14927.1 .
RefSeqi WP_010903920.1. NC_010364.1.
YP_001690273.1. NC_010364.1.

3D structure databases

ProteinModelPortali B0R858.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 478009.OE4610R.

Proteomic databases

PRIDEi B0R858.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAP14927 ; CAP14927 ; OE_4610R .
GeneIDi 5953444.
KEGGi hsl:OE4610R.

Phylogenomic databases

eggNOGi COG0717.
HOGENOMi HOG000228599.
KOi K01520.
OMAi WDAGYEG.

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .
BioCyci HSAL478009:GJVF-2097-MONOMER.

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
HAMAPi MF_00635. dUTPase_arch.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR023537. dUTPase_archaeal.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Evolution in the laboratory: the genome of Halobacterium salinarum strain R1 compared to that of strain NRC-1."
    Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K., Ruepp A., Soppa J., Tittor J., Oesterhelt D.
    Genomics 91:335-346(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29341 / DSM 671 / R1.

Entry informationi

Entry nameiDUT_HALS3
AccessioniPrimary (citable) accession number: B0R858
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3