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B0R7V5 (ARLY_HALS3) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:OE4419R
OrganismHalobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) [Complete proteome] [HAMAP]
Taxonomic identifier478009 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halobacterium

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 485485Argininosuccinate lyase HAMAP MF_00006
PRO_1000089085

Sequences

Sequence LengthMass (Da)Tools
B0R7V5 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 5C23512E63CBEA29

FASTA48548,792
        10         20         30         40         50         60 
MTGGGDPVVR RDRFSGGPAR SFLSSMDGDG RIFEADLAVD RAHVVMLAEQ DVIGDEAAAA 

        70         80         90        100        110        120 
ILGALADVEA AGFDALPPGE DVHEAIETAV VEAVGRDGGK LHTARSRNDE VAACIRYRLR 

       130        140        150        160        170        180 
ADLLDAIEVV VALRSALADV AAAEAETVMP GFTHLQPAQP TTVAHWALSY AGTLARDTGR 

       190        200        210        220        230        240 
LCDAYGRTNE SPLGAAAFAG TTFGVDRERT AALLGFDGVV ANAADAAASR DFLLEAVSAL 

       250        260        270        280        290        300 
ASVAVTCSGL AADVVFFANR GFVEVSDDYA STSSIMPQKK NPDTMELVRA TAGDAVGAQQ 

       310        320        330        340        350        360 
ALATTLQGLP RAYNRDLQRA TGHAWTAVDG VTSAVEVAAG VVATAGWPAD DLEAAAGEGF 

       370        380        390        400        410        420 
STATGVADAL AAGGLPFRTA HEVVALAAER GCEGATLDAV AAATEAVTGE PLSAVVEPAA 

       430        440        450        460        470        480 
VADALDPVGS VAARDSAGGP APAAVEAAVA DVRDGIDADE AALAAERASL ADAADALAAE 


VSGYV

« Hide

References

[1]"Evolution in the laboratory: the genome of Halobacterium salinarum strain R1 compared to that of strain NRC-1."
Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K., Ruepp A., Soppa J., Tittor J., Oesterhelt D.
Genomics 91:335-346(2008) [PubMed: 18313895] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29341 / DSM 671 / R1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM774415 Genomic DNA. Translation: CAP14824.1.
RefSeqYP_001690170.1. NC_010364.1.

3D structure databases

ProteinModelPortalB0R7V5.
ModBaseSearch...

Protein-protein interaction databases

STRINGB0R7V5.

Proteomic databases

PRIDEB0R7V5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5953385.
GenomeReviewsGene locus OE4419R in contig AM774415_GR.
KEGGhsl:OE4419R.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG539632.
OMAEDIHTVI.
PhylomeDBB0R7V5.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycHSAL478009:OE4419R-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_HALS3
AccessionPrimary (citable) accession number: B0R7V5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 8, 2008
Last modified: December 14, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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