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B0R7L9

- GSA_HALS3

UniProt

B0R7L9 - GSA_HALS3

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Protein
Glutamate-1-semialdehyde 2,1-aminomutase
Gene
hemL, OE_4268F
Organism
Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciHSAL478009:GJVF-1897-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:OE_4268F
OrganismiHalobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Taxonomic identifieri478009 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000001321: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation
PRO_1000201040Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei264 – 2641N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiB0R7L9.

Interactioni

Protein-protein interaction databases

STRINGi478009.OE4268F.

Structurei

3D structure databases

ProteinModelPortaliB0R7L9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiHYPSIDM.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 2 hits.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0R7L9-1 [UniParc]FASTAAdd to Basket

« Hide

MNRETSRELY DRSLDVLVGG VNSTVRAAPQ PYPTFVQSGD GGHVIDADGN    50
RYIDWVMGLG PLLLGHDLPQ PVTAAIQRRA SDGPLFGTPT EIEVEHAEFV 100
ARHVPSVELL RFVNSGTEAT VSAVRLARGY TGRNKIVVMQ GGYHGAQEST 150
LVEGDADHRG PSSAGIPPAF AQHTIPVPFN DADAVTEVFE THGDDIAAVL 200
VEPILANKGI VEPVAGYHET LRDLTHDHGA LLIWDEVITG FRVGGLGCAQ 250
SEFDITPDVT TFGKIIGGGF PVGAIGGRTD VMEEFTPTGD VFQAGTFSGH 300
PVTMAAGLET LQYAAENDVY EHVNRLGGRL REGLAAVVAE HAPAYTVVGR 350
DSMFKVVFTR DGDAQSGACT DGCRQDPDCE RHAACPKTGA DVGDAAVQRW 400
NRVFRPQLLD AGVLLSQNQF ESQFVSYGHT EADVDETIEA YRSAL 445
Length:445
Mass (Da):47,619
Last modified:April 8, 2008 - v1
Checksum:iC6065E6A729C9C7C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM774415 Genomic DNA. Translation: CAP14738.1.
RefSeqiWP_010903735.1. NC_010364.1.
YP_001690084.1. NC_010364.1.

Genome annotation databases

EnsemblBacteriaiCAP14738; CAP14738; OE_4268F.
GeneIDi5953343.
KEGGihsl:OE4268F.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM774415 Genomic DNA. Translation: CAP14738.1 .
RefSeqi WP_010903735.1. NC_010364.1.
YP_001690084.1. NC_010364.1.

3D structure databases

ProteinModelPortali B0R7L9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 478009.OE4268F.

Proteomic databases

PRIDEi B0R7L9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAP14738 ; CAP14738 ; OE_4268F .
GeneIDi 5953343.
KEGGi hsl:OE4268F.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi HYPSIDM.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci HSAL478009:GJVF-1897-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 2 hits.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution in the laboratory: the genome of Halobacterium salinarum strain R1 compared to that of strain NRC-1."
    Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K., Ruepp A., Soppa J., Tittor J., Oesterhelt D.
    Genomics 91:335-346(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29341 / DSM 671 / R1.

Entry informationi

Entry nameiGSA_HALS3
AccessioniPrimary (citable) accession number: B0R7L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: April 8, 2008
Last modified: September 3, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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