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B0R7L6 (B0R7L6_HALS3) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515
Gene names
Name:hemB EMBL CAP14735.1
Ordered Locus Names:OE4262F
OrganismHalobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) [Complete proteome] [HAMAP]
Taxonomic identifier478009 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halobacterium

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515

Subunit structure

Homooctamer By similarity. RuleBase RU000515 PIRSR PIRSR001415-3

Sequence similarities

Belongs to the ALADH family. RuleBase RU004161

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1991Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
Active site2521Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
Metal binding1171Zinc; catalytic By similarity PIRSR PIRSR001415-3
Metal binding1191Zinc; catalytic By similarity PIRSR PIRSR001415-3
Metal binding1271Zinc; catalytic By similarity PIRSR PIRSR001415-3
Metal binding2371Magnesium By similarity PIRSR PIRSR001415-5
Binding site2091Substrate 1 By similarity PIRSR PIRSR001415-2
Binding site2211Substrate 1 By similarity PIRSR PIRSR001415-2
Binding site2781Substrate 2 By similarity PIRSR PIRSR001415-2
Binding site3171Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

Sequence LengthMass (Da)Tools
B0R7L6 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: A9E6CDCDE3482060

FASTA32635,384
        10         20         30         40         50         60 
MELPHRPRRL RRDGVRDLVS ETMLTPADLV APVFVDATAD ERTPIPSMPG QERVPLADAV 

        70         80         90        100        110        120 
DRTREILDTG VEAIVLFGIP ASKDDTGSRA YADDGIVQEA TRRITSETDA YVITDVCLCE 

       130        140        150        160        170        180 
YTSHGHCGVV EADADTDPTL TVKNDETLSL LAETAVSHAE AGAEMIAPSA MTDGMVDAIR 

       190        200        210        220        230        240 
TALDDAGFSD VPIMSYAAKY ESAFYGPFRD AADGAPSFGD RRHYQMDPAN RREASREVAL 

       250        260        270        280        290        300 
DVEQGADVLM VKPALPYLDV VSDVRREFDR PVAAYNVSGE YAMLHAAAEK GWLDLESVAH 

       310        320 
ESLLSIKRAG ADLIITYFAE DVAETL

« Hide

References

[1]"Evolution in the laboratory: the genome of Halobacterium salinarum strain R1 compared to that of strain NRC-1."
Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K., Ruepp A., Soppa J., Tittor J., Oesterhelt D.
Genomics 91:335-346(2008) [PubMed: 18313895] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29341 / DSM 671 / R1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM774415 Genomic DNA. Translation: CAP14735.1.
RefSeqYP_001690081.1. NC_010364.1.

3D structure databases

ProteinModelPortalB0R7L6.
SMRB0R7L6. Positions 5-326.
ModBaseSearch...

Protein-protein interaction databases

STRINGB0R7L6.

Proteomic databases

PRIDEB0R7L6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5953341.
GenomeReviewsGene locus OE4262F in contig AM774415_GR.
KEGGhsl:OE4262F.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG285270.
OMAADLCFCE.
PhylomeDBB0R7L6.
ProtClustDBPRK09283.

Family and domain databases

InterProIPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01698.
PANTHERPTHR11458. AlaD_dehydratase. 1 hit.
PfamPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSPR00144. DALDHYDRTASE.
SMARTSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB0R7L6_HALS3
AccessionPrimary (citable) accession number: B0R7L6
Entry history
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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