ID   CAPPA_HALS3             Reviewed;         492 AA.
AC   B0R7F9;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 79.
DE   RecName: Full=Phosphoenolpyruvate carboxylase {ECO:0000255|HAMAP-Rule:MF_01904};
DE            Short=PEPC {ECO:0000255|HAMAP-Rule:MF_01904};
DE            Short=PEPCase {ECO:0000255|HAMAP-Rule:MF_01904};
DE            EC=4.1.1.31 {ECO:0000255|HAMAP-Rule:MF_01904};
GN   Name=ppcA {ECO:0000255|HAMAP-Rule:MF_01904};
GN   OrderedLocusNames=OE_4169F;
OS   Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium; Halobacterium salinarum NRC-34001.
OX   NCBI_TaxID=478009;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29341 / DSM 671 / R1;
RX   PubMed=18313895; DOI=10.1016/j.ygeno.2008.01.001;
RA   Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K.,
RA   Ruepp A., Soppa J., Tittor J., Oesterhelt D.;
RT   "Evolution in the laboratory: the genome of Halobacterium salinarum strain
RT   R1 compared to that of strain NRC-1.";
RL   Genomics 91:335-346(2008).
CC   -!- FUNCTION: Catalyzes the irreversible beta-carboxylation of
CC       phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon
CC       dicarboxylic acid source for the tricarboxylic acid cycle.
CC       {ECO:0000255|HAMAP-Rule:MF_01904}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=oxaloacetate + phosphate = hydrogencarbonate +
CC         phosphoenolpyruvate; Xref=Rhea:RHEA:28370, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:17544, ChEBI:CHEBI:43474, ChEBI:CHEBI:58702; EC=4.1.1.31;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01904};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01904};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_01904}.
CC   -!- SIMILARITY: Belongs to the PEPCase type 2 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01904}.
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DR   EMBL; AM774415; CAP14678.1; -; Genomic_DNA.
DR   RefSeq; WP_010903679.1; NC_010364.1.
DR   AlphaFoldDB; B0R7F9; -.
DR   SMR; B0R7F9; -.
DR   EnsemblBacteria; CAP14678; CAP14678; OE_4169F.
DR   GeneID; 68694809; -.
DR   KEGG; hsl:OE_4169F; -.
DR   HOGENOM; CLU_517433_0_0_2; -.
DR   PhylomeDB; B0R7F9; -.
DR   Proteomes; UP000001321; Chromosome.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008964; F:phosphoenolpyruvate carboxylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015977; P:carbon fixation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006107; P:oxaloacetate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   HAMAP; MF_01904; PEPcase_type2; 1.
DR   InterPro; IPR007566; PEP_COase_arc-type.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   NCBIfam; TIGR02751; PEPCase_arch; 1.
DR   Pfam; PF14010; PEPcase_2; 1.
DR   PIRSF; PIRSF006677; UCP006677; 1.
DR   SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
PE   3: Inferred from homology;
KW   Carbon dioxide fixation; Lyase; Magnesium.
FT   CHAIN           1..492
FT                   /note="Phosphoenolpyruvate carboxylase"
FT                   /id="PRO_1000188767"
SQ   SEQUENCE   492 AA;  54179 MW;  12FBE025EF21C6D2 CRC64;
     MVDVPRLMST QHPDNATLPF FTAGDVIEGE DEIQEAYYVY SHLGCDEQMW DFEGKEGDEY
     AVKKLLSRYD EFFADHQLGT DVRLTVRGPN PDVEGSEAKI LLEILESIPR SFDAARRFAG
     EYGLETTAPI FEVIVPMVTD ADQLNAVHEY YERFVTGKAD EAVWDGRTVE EWVGEFDPAS
     ITVIPLIEER EAMLAADDIV REYATAHDQD AVRVFLARSD PALNYGCLAA DLINKVALQR
     LYEMSEATGV DVHPILGAGS APFRGNLTPE RAAATADAYS EVETFTVQSA FKYDYPVETV
     RDGVATLRDA DLGAPPFPID EARALAVIDR TADAYADQVD AIAGTVNRLS SYVPDRRARK
     LHVGLFGYAR EVGENALPRA IGYTASLYAV GCPPTLLGAH ALTDDDAAFV REAFPAYFDH
     LADAARYFNP RCTDVLDLDD DTLAAAVERV DVTPNSEHRA ATDDAIDALQ RGDDDALRSA
     IRRGARERQF LG
//