B0R6U7 (PDAD_HALS3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyruvoyl-dependent arginine decarboxylase
Short name=PvlArgDC
EC=4.1.1.19

Cleaved into the following 2 chains:

1. Pyruvoyl-dependent arginine decarboxylase subunit beta
2. Pyruvoyl-dependent arginine decarboxylase subunit alpha

Gene names

Name:	pdaD
Ordered Locus Names:	OE3803R

Organism

Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) [Complete proteome] [HAMAP]

Taxonomic identifier

478009 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halobacterium

Protein attributes

Sequence length	160 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-arginine = agmatine + CO2. HAMAP MF_01404
Cofactor	Pyruvoyl group By similarity. HAMAP MF_01404
Sequence similarities	Belongs to the pdaD family.

Ontologies

Keywords
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 38	38	Pyruvoyl-dependent arginine decarboxylase subunit beta By similarity		PRO_1000145468
	Chain	39 – 160	122	Pyruvoyl-dependent arginine decarboxylase subunit alpha By similarity		PRO_1000145469
Sites
	Site	38 – 39	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	39	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0R6U7 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: B77749F3A1E97BCD	FASTA	160	16,364
	10 20 30 40 50 60 MPRIRIAWGS GVAPTEMAAY DAALADANVH NYNLIRVSSV IPADATVSPV DTAPDLGPAG 70 80 90 100 110 120 NTLTVVEARG QTAGPGQASA GLAWAPRDGA PGLFYEAADE TTPDDVADRV TTGITAGMDV 130 140 150 160 RDWDGVEPSV RTETVTADAG EHAAAVVIAA YGDSDPVFDQ

References

[1]

"Evolution in the laboratory: the genome of Halobacterium salinarum strain R1 compared to that of strain NRC-1." Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K., Ruepp A., Soppa J., Tittor J., Oesterhelt D. Genomics 91:335-346(2008) [PubMed: 18313895] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29341 / DSM 671 / R1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM774415 Genomic DNA. Translation: CAP14466.1.
RefSeq	YP_001689812.1. NC_010364.1.
3D structure databases
ProteinModelPortal	B0R6U7.
ModBase	Search...
Protein-protein interaction databases
STRING	B0R6U7.
Proteomic databases
PRIDE	B0R6U7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5953199.
GenomeReviews	Gene locus OE3803R in contig AM774415_GR.
KEGG	hsl:OE3803R.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG497357.
OMA	GPGLFYE.
ProtClustDB	CLSK511582.
Enzyme and pathway databases
BioCyc	HSAL478009:OE3803R-MONOMER.
Family and domain databases
HAMAP	MF_01404. PvlArgDC. [Tree]
InterPro	IPR016104. Pyr-dep_his/arg-deCO2ase. IPR016105. Pyr-dep_his/arg-deCO2ase_sand. IPR002724. Pyruvoyl-dep_arg_deCO2ase. [Graphical view]
Gene3D	G3DSA:3.50.20.10. Pyr-dep_his/arg-deCO2ase_sand. 1 hit.
KO	K02626.
Pfam	PF01862. PvlArgDC. 1 hit. [Graphical view]
PIRSF	PIRSF005216. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
ProDom	PD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF56271. His_carbxylase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PDAD_HALS3

Accession

Primary (citable) accession number: B0R6U7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	April 8, 2008
Last modified:	November 16, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program