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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00071

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:OE_3721F
OrganismiHalobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Taxonomic identifieri478009 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000001321 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003987271 – 2092-phospho-L-lactate guanylyltransferaseAdd BLAST209

Proteomic databases

PRIDEiB0R6P7

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB0R6P7
SMRiB0R6P7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000223639
KOiK14941
OMAiFRVDYHG
OrthoDBiPOG093Z0CT7

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_02114 CofC, 1 hit
InterProiView protein in InterPro
IPR002835 Coenzyme_F420_CofC
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR40392 PTHR40392, 1 hit
PfamiView protein in Pfam
PF01983 CofC, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR03552 F420_cofC, 1 hit

Sequencei

Sequence statusi: Complete.

B0R6P7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTVVPFDPR DPKSRLAEFF ADAEERRGFA YAMLADVLGA VRDAGGDPVV
60 70 80 90 100
VATAPVSRPV DAPVTVDDRA LSTAVAAAIA DGPLPTAVVM ADLALATPDA
110 120 130 140 150
IRRVFAASGD VVLAPGSGGG TNVVLARTAD VPVSYHGVSF RDHVTAAERA
160 170 180 190 200
GLTVTTVDSF RLAADVDDAS DLVDVFVHNT RRTREWLIAG GWRLAVDDGT

PTVVREPND
Length:209
Mass (Da):21,875
Last modified:April 8, 2008 - v1
Checksum:i2D83C5960119CD1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM774415 Genomic DNA Translation: CAP14416.1
RefSeqiWP_010903420.1, NC_010364.1

Genome annotation databases

EnsemblBacteriaiCAP14416; CAP14416; OE_3721F
GeneIDi5953169
KEGGihsl:OE_3721F

Similar proteinsi

Entry informationi

Entry nameiCOFC_HALS3
AccessioniPrimary (citable) accession number: B0R6P7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: April 8, 2008
Last modified: May 23, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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