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Protein

NAD kinase

Gene

nadK

Organism
Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei67Proton acceptorUniRule annotation1
Binding sitei151NADUniRule annotation1
Binding sitei170NADUniRule annotation1
Binding sitei172NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi67 – 68NADUniRule annotation2
Nucleotide bindingi140 – 141NADUniRule annotation2
Nucleotide bindingi183 – 188NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:OE_3671F
OrganismiHalobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Taxonomic identifieri478009 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000001321 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001208641 – 282NAD kinaseAdd BLAST282

Proteomic databases

PRIDEiB0R6L8

Structurei

3D structure databases

SMRiB0R6L8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227222
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG093Z07HH

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 1 hit
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

B0R6L8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVGIVAQRG NERATSLAGE IREQLRALEV TVWVDTATAE ALACAGECGR
60 70 80 90 100
DTTAFTDCDL VVSIGGDGTF LFAARGAGAT PILGVNLGEV GFLNAVAPAD
110 120 130 140 150
AVEAVREEVN RYRETGAVRC REVPRVVAAG DGWASTPALN EVAIQGEQRG
160 170 180 190 200
HGHGVAVDVR VDGSQYEATR ADGVLVATPT GSTAYNLSEG GPLVQPSVDA
210 220 230 240 250
LVVTEMCGAD ALPPLVTGLD SEIRIRVETL DDGGEGRVVV ASDGGRLTRV
260 270 280
DPPVEMTVTA ADEPARVAGP AADFFEALSK LE
Length:282
Mass (Da):29,121
Last modified:April 8, 2008 - v1
Checksum:i5DA1AF25147D7500
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM774415 Genomic DNA Translation: CAP14387.1
RefSeqiWP_010903393.1, NC_010364.1

Genome annotation databases

EnsemblBacteriaiCAP14387; CAP14387; OE_3671F
GeneIDi5953153
KEGGihsl:OE_3671F

Similar proteinsi

Entry informationi

Entry nameiNADK_HALS3
AccessioniPrimary (citable) accession number: B0R6L8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: April 25, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health