B0R6I6 (DEOC_HALS3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase
Short name=DERA
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name=Deoxyriboaldolase

Gene names

Name:	deoC
Ordered Locus Names:	OE3616F

Organism

Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) [Complete proteome] [HAMAP]

Taxonomic identifier

478009 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halobacterium

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP MF_00114
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity HAMAP MF_00114.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Deoxyribose-phosphate aldolase HAMAP MF_00114		PRO_1000094847
Sites
	Active site	151	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	176	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0R6I6 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: F9DCF56817DE87DA	FASTA	212	21,472
	10 20 30 40 50 60 MDRETLAARI DHTVLGPTTT RADVLSVVDD AEAHGMNVCI PPCYVADARD HASADRTIAT 70 80 90 100 110 120 VIGFPHGTQA TSVKVAAAEH AHADGADELD LVIPIGRLKG GDHEAVTAEI AAVNDATPLP 130 140 150 160 170 180 VKVIIETPVL TDAEKHAACE AAADADAAMV KTATGFTDGG ATVPDVSLMS EYLPVKASGG 190 200 210 VGTYADAAAM FDAGAVRIGA SSGVDIVASF AE

References

[1]

"Evolution in the laboratory: the genome of Halobacterium salinarum strain R1 compared to that of strain NRC-1." Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K., Ruepp A., Soppa J., Tittor J., Oesterhelt D. Genomics 91:335-346(2008) [PubMed: 18313895] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29341 / DSM 671 / R1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM774415 Genomic DNA. Translation: CAP14355.1.
RefSeq	YP_001689701.1. NC_010364.1.
3D structure databases
ProteinModelPortal	B0R6I6.
ModBase	Search...
Protein-protein interaction databases
STRING	B0R6I6.
Proteomic databases
PRIDE	B0R6I6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5953581.
GenomeReviews	Gene locus OE3616F in contig AM774415_GR.
KEGG	hsl:OE3616F.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG636421.
OMA	IDHTNLK.
PhylomeDB	B0R6I6.
ProtClustDB	CLSK511544.
Enzyme and pathway databases
BioCyc	HSAL478009:OE3616F-MONOMER.
Family and domain databases
HAMAP	MF_00114. DeoC_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. IPR022979. Deoxyribose_phosphate_aldo_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01619.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. DeoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_HALS3

Accession

Primary (citable) accession number: B0R6I6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	April 8, 2008
Last modified:	December 14, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program