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B0R642

- PYRF_HALS3

UniProt

B0R642 - PYRF_HALS3

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei93 – 931Proton donorUniRule annotation

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    BioCyciHSAL478009:GJVF-1360-MONOMER.
    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
    Alternative name(s):
    OMP decarboxylaseUniRule annotation
    Short name:
    OMPDCaseUniRule annotation
    Short name:
    OMPdecaseUniRule annotation
    Gene namesi
    Name:pyrFUniRule annotation
    Ordered Locus Names:OE_3363F
    OrganismiHalobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
    Taxonomic identifieri478009 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
    ProteomesiUP000001321: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 267267Orotidine 5'-phosphate decarboxylasePRO_1000138953Add
    BLAST

    Proteomic databases

    PRIDEiB0R642.

    Interactioni

    Protein-protein interaction databases

    STRINGi478009.OE3363F.

    Structurei

    3D structure databases

    ProteinModelPortaliB0R642.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000245747.
    KOiK01591.
    OMAiYAHGKNV.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01215. OMPdecase_type2.
    InterProiIPR013785. Aldolase_TIM.
    IPR018089. OMPdecase_AS.
    IPR011995. OMPdecase_type-2.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0R642-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFVEELGAR IEAADSVVSV GLDPDMERLP EDVQDAELPR WAFNRRIIDA    50
    THEHAAVFKP NAAFYEDSDG WRALRETVAY AHGKGVPVLL DAKRADIGNT 100
    ARQYAEILAH VDAITVNPYL GEDALQPFLT QDEAGVFVLC RTSNEGGMDF 150
    QHLELAAYDR RLYEHVAERA AEWNAQYGDV GLVVGATAPD ELQAIRERVP 200
    ELPFLVPGVG AQGGDAEAAV EYGLNDDGVG LVNSTRGVIF AGEHGSAWAA 250
    AAGDAARTLR ERLNRHR 267
    Length:267
    Mass (Da):29,048
    Last modified:April 8, 2008 - v1
    Checksum:iB478E72A42572111
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM774415 Genomic DNA. Translation: CAP14211.1.
    RefSeqiWP_010903220.1. NC_010364.1.
    YP_001689557.1. NC_010364.1.

    Genome annotation databases

    EnsemblBacteriaiCAP14211; CAP14211; OE_3363F.
    GeneIDi5953071.
    KEGGihsl:OE3363F.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM774415 Genomic DNA. Translation: CAP14211.1 .
    RefSeqi WP_010903220.1. NC_010364.1.
    YP_001689557.1. NC_010364.1.

    3D structure databases

    ProteinModelPortali B0R642.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 478009.OE3363F.

    Proteomic databases

    PRIDEi B0R642.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAP14211 ; CAP14211 ; OE_3363F .
    GeneIDi 5953071.
    KEGGi hsl:OE3363F.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000245747.
    KOi K01591.
    OMAi YAHGKNV.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .
    BioCyci HSAL478009:GJVF-1360-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01215. OMPdecase_type2.
    InterProi IPR013785. Aldolase_TIM.
    IPR018089. OMPdecase_AS.
    IPR011995. OMPdecase_type-2.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution in the laboratory: the genome of Halobacterium salinarum strain R1 compared to that of strain NRC-1."
      Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K., Ruepp A., Soppa J., Tittor J., Oesterhelt D.
      Genomics 91:335-346(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29341 / DSM 671 / R1.

    Entry informationi

    Entry nameiPYRF_HALS3
    AccessioniPrimary (citable) accession number: B0R642
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3