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B0R5Y6

- GCSPA_HALS3

UniProt

B0R5Y6 - GCSPA_HALS3

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciHSAL478009:GJVF-1302-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:OE_3275R
OrganismiHalobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Taxonomic identifieri478009 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000001321: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000132482Add
BLAST

Proteomic databases

PRIDEiB0R5Y6.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi478009.OE3275R.

Structurei

3D structure databases

ProteinModelPortaliB0R5Y6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiGLEVANC.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B0R5Y6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGSPYASPS EADTDAMLDA VGVDRVDELF DIPPEVSFDG EFGIDAKSEQ
60 70 80 90 100
AALRGVRRRL SDNDDLTEFL GRGHYEHYVP SLVDSVSQRS EFITSYTQYQ
110 120 130 140 150
PEITQGFLQV LFEYQSLLVE LTGLGVANCS MYDAATALAE AALLAKRVRA
160 170 180 190 200
ADGNRVLVPG FVRDSHVDVL RNYTSGSDVV VERYATDAGN VDLDALEAAM
210 220 230 240 250
DADVVMVYAE NPTTCGTVEE QLCAVGDLAD SHDALFCLGS DPVAMSILQR
260 270 280 290 300
PVDVGADVVV GDASVLGMPT SYGTGLGVFA TRKEFLRQVP GRLVGASEDD
310 320 330 340 350
AGTRAFTLTL QTREQHIRKE RATSNICTNQ AWVALRAAIH AAWLGADGLV
360 370 380 390 400
DLAERMVELP RDLAARLDDV SGVTAPVHDD RHHIREFQAR TEQPAPAVAS
410 420 430 440
ALEAEGFGVH AVDDHTIQVC VTDANEHATD AFVAAVREVS E
Length:441
Mass (Da):47,460
Last modified:April 8, 2008 - v1
Checksum:iC3D83F0DF88F6E4D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM774415 Genomic DNA. Translation: CAP14155.1.
RefSeqiWP_010903166.1. NC_010364.1.
YP_001689501.1. NC_010364.1.

Genome annotation databases

EnsemblBacteriaiCAP14155; CAP14155; OE_3275R.
GeneIDi5953783.
KEGGihsl:OE3275R.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM774415 Genomic DNA. Translation: CAP14155.1 .
RefSeqi WP_010903166.1. NC_010364.1.
YP_001689501.1. NC_010364.1.

3D structure databases

ProteinModelPortali B0R5Y6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 478009.OE3275R.

Proteomic databases

PRIDEi B0R5Y6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAP14155 ; CAP14155 ; OE_3275R .
GeneIDi 5953783.
KEGGi hsl:OE3275R.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi GLEVANC.

Enzyme and pathway databases

BioCyci HSAL478009:GJVF-1302-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Evolution in the laboratory: the genome of Halobacterium salinarum strain R1 compared to that of strain NRC-1."
    Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K., Ruepp A., Soppa J., Tittor J., Oesterhelt D.
    Genomics 91:335-346(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29341 / DSM 671 / R1.

Entry informationi

Entry nameiGCSPA_HALS3
AccessioniPrimary (citable) accession number: B0R5Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: October 1, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3