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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:OE_3275R
OrganismiHalobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Taxonomic identifieri478009 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000001321 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001324821 – 441Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST441

Proteomic databases

PRIDEiB0R5Y6

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB0R5Y6
SMRiB0R5Y6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG093Z02N9

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

B0R5Y6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSPYASPS EADTDAMLDA VGVDRVDELF DIPPEVSFDG EFGIDAKSEQ
60 70 80 90 100
AALRGVRRRL SDNDDLTEFL GRGHYEHYVP SLVDSVSQRS EFITSYTQYQ
110 120 130 140 150
PEITQGFLQV LFEYQSLLVE LTGLGVANCS MYDAATALAE AALLAKRVRA
160 170 180 190 200
ADGNRVLVPG FVRDSHVDVL RNYTSGSDVV VERYATDAGN VDLDALEAAM
210 220 230 240 250
DADVVMVYAE NPTTCGTVEE QLCAVGDLAD SHDALFCLGS DPVAMSILQR
260 270 280 290 300
PVDVGADVVV GDASVLGMPT SYGTGLGVFA TRKEFLRQVP GRLVGASEDD
310 320 330 340 350
AGTRAFTLTL QTREQHIRKE RATSNICTNQ AWVALRAAIH AAWLGADGLV
360 370 380 390 400
DLAERMVELP RDLAARLDDV SGVTAPVHDD RHHIREFQAR TEQPAPAVAS
410 420 430 440
ALEAEGFGVH AVDDHTIQVC VTDANEHATD AFVAAVREVS E
Length:441
Mass (Da):47,460
Last modified:April 8, 2008 - v1
Checksum:iC3D83F0DF88F6E4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM774415 Genomic DNA Translation: CAP14155.1
RefSeqiWP_010903166.1, NC_010364.1

Genome annotation databases

EnsemblBacteriaiCAP14155; CAP14155; OE_3275R
GeneIDi5953783
KEGGihsl:OE_3275R

Similar proteinsi

Entry informationi

Entry nameiGCSPA_HALS3
AccessioniPrimary (citable) accession number: B0R5Y6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: April 25, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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