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B0R5Y6 (GCSPA_HALS3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:OE_3275R
OrganismHalobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) [Complete proteome] [HAMAP]
Taxonomic identifier478009 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium

Protein attributes

Sequence length441 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 441441Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000132482

Sequences

Sequence LengthMass (Da)Tools
B0R5Y6 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: C3D83F0DF88F6E4D

FASTA44147,460
        10         20         30         40         50         60 
MSGSPYASPS EADTDAMLDA VGVDRVDELF DIPPEVSFDG EFGIDAKSEQ AALRGVRRRL 

        70         80         90        100        110        120 
SDNDDLTEFL GRGHYEHYVP SLVDSVSQRS EFITSYTQYQ PEITQGFLQV LFEYQSLLVE 

       130        140        150        160        170        180 
LTGLGVANCS MYDAATALAE AALLAKRVRA ADGNRVLVPG FVRDSHVDVL RNYTSGSDVV 

       190        200        210        220        230        240 
VERYATDAGN VDLDALEAAM DADVVMVYAE NPTTCGTVEE QLCAVGDLAD SHDALFCLGS 

       250        260        270        280        290        300 
DPVAMSILQR PVDVGADVVV GDASVLGMPT SYGTGLGVFA TRKEFLRQVP GRLVGASEDD 

       310        320        330        340        350        360 
AGTRAFTLTL QTREQHIRKE RATSNICTNQ AWVALRAAIH AAWLGADGLV DLAERMVELP 

       370        380        390        400        410        420 
RDLAARLDDV SGVTAPVHDD RHHIREFQAR TEQPAPAVAS ALEAEGFGVH AVDDHTIQVC 

       430        440 
VTDANEHATD AFVAAVREVS E 

« Hide

References

[1]"Evolution in the laboratory: the genome of Halobacterium salinarum strain R1 compared to that of strain NRC-1."
Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K., Ruepp A., Soppa J., Tittor J., Oesterhelt D.
Genomics 91:335-346(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29341 / DSM 671 / R1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM774415 Genomic DNA. Translation: CAP14155.1.
RefSeqYP_001689501.1. NC_010364.1.

3D structure databases

ProteinModelPortalB0R5Y6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING478009.OE3275R.

Proteomic databases

PRIDEB0R5Y6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAP14155; CAP14155; OE_3275R.
GeneID5953783.
KEGGhsl:OE3275R.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMAGLEVANC.

Enzyme and pathway databases

BioCycHSAL478009:GJVF-1302-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_HALS3
AccessionPrimary (citable) accession number: B0R5Y6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families