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B0R4Z6

- SYE_HALS3

UniProt

B0R4Z6 - SYE_HALS3

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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHSAL478009:GJVF-951-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:OE_2652F
OrganismiHalobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Taxonomic identifieri478009 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000001321: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 586586Glutamate--tRNA ligasePRO_1000090079Add
BLAST

Proteomic databases

PRIDEiB0R4Z6.

Interactioni

Protein-protein interaction databases

STRINGi478009.OE2652F.

Structurei

3D structure databases

ProteinModelPortaliB0R4Z6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi114 – 12411"HIGH" regionAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000073585.
KOiK01885.
OMAiAFRIIDT.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_A. Glu_tRNA_synth_A.
InterProiIPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00463. gltX_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

B0R4Z6-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MDDELRERVR RAAERAALFN ALKHGSDAQV GAIMGPMMGE HPDFRAHGDE
60 70 80 90 100
IPGVIAPVIE DVNGMSDDEQ RARLAELAPE DVEELDSEDE GDDHALPALP
110 120 130 140 150
NAEAYDEVRM RCAPNPNGPW HVGHARMPSV IGTYKQRYDG SFVVRFDDTD
160 170 180 190 200
PETKRPDLDA YDQILEDLSY LGFEADEVLT ASDRVETYYE HARRLIGMGG
210 220 230 240 250
AYTCSCPGAE FSDLKNSGEA CPHRDKDPET VADEFEAMVD GEYNSGEMVL
260 270 280 290 300
RVKTDITHKN PALRDWVAFR MVDTPHPRDA ASGYRCWPML DFQSGVDDHR
310 320 330 340 350
TGVTHIIRGI DLQDSAKRQR FLYEYFGWEY PEVVHWGHVQ LDAYDVAMST
360 370 380 390 400
STIKERIAAG ELEGWDDPRA PTMQSIRRRG IRGAAVVDAM VELGTSSSDV
410 420 430 440 450
ELAMSAVYAN NRDLVDDTAP RQFLVRDGFE ARGEGPEESH EAVEVPVDDG
460 470 480 490 500
PDEATPQVHP EHPDRGDREI PVGERVLVEA TDLPAAGDRV WLKGYGPVRY
510 520 530 540 550
DGERFAFLDA DIDIVREEGV DVVQWVPAEH NVDVRLRTMD GDVTGYAEPG
560 570 580
FADRDADEIV QFVRVGFARV DAHRDGGASV AYFTHP
Length:586
Mass (Da):65,312
Last modified:April 8, 2008 - v1
Checksum:iE844ED37F8F46776
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM774415 Genomic DNA. Translation: CAP13811.1.
RefSeqiWP_010902829.1. NC_010364.1.
YP_001689159.1. NC_010364.1.

Genome annotation databases

EnsemblBacteriaiCAP13811; CAP13811; OE_2652F.
GeneIDi5952846.
KEGGihsl:OE2652F.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM774415 Genomic DNA. Translation: CAP13811.1 .
RefSeqi WP_010902829.1. NC_010364.1.
YP_001689159.1. NC_010364.1.

3D structure databases

ProteinModelPortali B0R4Z6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 478009.OE2652F.

Proteomic databases

PRIDEi B0R4Z6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAP13811 ; CAP13811 ; OE_2652F .
GeneIDi 5952846.
KEGGi hsl:OE2652F.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000073585.
KOi K01885.
OMAi AFRIIDT.

Enzyme and pathway databases

BioCyci HSAL478009:GJVF-951-MONOMER.

Family and domain databases

Gene3Di 1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_A. Glu_tRNA_synth_A.
InterProi IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF50715. SSF50715. 1 hit.
TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Evolution in the laboratory: the genome of Halobacterium salinarum strain R1 compared to that of strain NRC-1."
    Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K., Ruepp A., Soppa J., Tittor J., Oesterhelt D.
    Genomics 91:335-346(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29341 / DSM 671 / R1.

Entry informationi

Entry nameiSYE_HALS3
AccessioniPrimary (citable) accession number: B0R4Z6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3