gltX

Functionⁱ

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityⁱ

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
glutamate-tRNA ligase activity Source: UniProtKB-EC

Complete GO annotation...

GO - Biological processⁱ

glutamyl-tRNA aminoacylation Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Aminoacyl-tRNA synthetase, Ligase
Biological process	Protein biosynthesis
Ligand	ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation) Alternative name(s): Glutamyl-tRNA synthetaseUniRule annotation Short name: GluRSUniRule annotation
Gene namesⁱ	Name:gltXUniRule annotation Ordered Locus Names:OE_2652F
Organismⁱ	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Taxonomic identifierⁱ	478009 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halobacterium › Halobacterium salinarum
Proteomesⁱ	UP000001321 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_02076

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_1000090079	1 – 586	Glutamate--tRNA ligaseAdd BLAST		586

Proteomic databases

PRIDEⁱ	B0R4Z6.

PRIDEⁱ

B0R4Z6.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B0R4Z6.
SMRⁱ	B0R4Z6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	114 – 124	"HIGH" regionUniRule annotationAdd BLAST		11

Sequence similaritiesⁱ

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMⁱ	HOG000073585.
KEGG Orthology (KO) More...KOⁱ	K01885.
OMAⁱ	MRFAPNP.
Database of Orthologous Groups More...OrthoDBⁱ	POG093Z013J.

Family and domain databases

Gene3Dⁱ	1.10.1160.10. 1 hit. 3.40.50.620. 2 hits.
HAMAPⁱ	MF_02076. Glu_tRNA_synth_type2. 1 hit.
InterProⁱ	View protein in InterPro IPR004526. Glu-tRNA-synth_arc/euk. IPR000924. Glu/Gln-tRNA-synth. IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl. IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom. IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd. IPR011035. Ribosomal_L25/Gln-tRNA_synth. IPR014729. Rossmann-like_a/b/a_fold.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00749. tRNA-synt_1c. 1 hit. PF03950. tRNA-synt_1c_C. 1 hit.
PRINTSⁱ	PR00987. TRNASYNTHGLU.
SUPFAMⁱ	SSF50715. SSF50715. 1 hit.
TIGRFAMsⁱ	TIGR00463. gltX_arch. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B0R4Z6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDDELRERVR RAAERAALFN ALKHGSDAQV GAIMGPMMGE HPDFRAHGDE 
        60         70         80         90        100
IPGVIAPVIE DVNGMSDDEQ RARLAELAPE DVEELDSEDE GDDHALPALP 
       110        120        130        140        150
NAEAYDEVRM RCAPNPNGPW HVGHARMPSV IGTYKQRYDG SFVVRFDDTD 
       160        170        180        190        200
PETKRPDLDA YDQILEDLSY LGFEADEVLT ASDRVETYYE HARRLIGMGG 
       210        220        230        240        250
AYTCSCPGAE FSDLKNSGEA CPHRDKDPET VADEFEAMVD GEYNSGEMVL 
       260        270        280        290        300
RVKTDITHKN PALRDWVAFR MVDTPHPRDA ASGYRCWPML DFQSGVDDHR 
       310        320        330        340        350
TGVTHIIRGI DLQDSAKRQR FLYEYFGWEY PEVVHWGHVQ LDAYDVAMST 
       360        370        380        390        400
STIKERIAAG ELEGWDDPRA PTMQSIRRRG IRGAAVVDAM VELGTSSSDV 
       410        420        430        440        450
ELAMSAVYAN NRDLVDDTAP RQFLVRDGFE ARGEGPEESH EAVEVPVDDG 
       460        470        480        490        500
PDEATPQVHP EHPDRGDREI PVGERVLVEA TDLPAAGDRV WLKGYGPVRY 
       510        520        530        540        550
DGERFAFLDA DIDIVREEGV DVVQWVPAEH NVDVRLRTMD GDVTGYAEPG 
       560        570        580 
FADRDADEIV QFVRVGFARV DAHRDGGASV AYFTHP

Length:586

Mass (Da):65,312

Last modified:April 8, 2008 - v1

Checksum:ⁱE844ED37F8F46776

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AM774415 Genomic DNA. Translation: CAP13811.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_010902829.1. NC_010364.1.

Genome annotation databases

EnsemblBacteriaⁱ	CAP13811; CAP13811; OE_2652F.
GeneIDⁱ	5952846.
KEGGⁱ	hsl:OE_2652F.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AM774415 Genomic DNA. Translation: CAP13811.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_010902829.1. NC_010364.1.

3D structure databases

ProteinModelPortalⁱ	B0R4Z6.
SMRⁱ	B0R4Z6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	B0R4Z6.

PRIDEⁱ

B0R4Z6.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	CAP13811; CAP13811; OE_2652F.
GeneIDⁱ	5952846.
KEGGⁱ	hsl:OE_2652F.

Phylogenomic databases

HOGENOMⁱ	HOG000073585.
KEGG Orthology (KO) More...KOⁱ	K01885.
OMAⁱ	MRFAPNP.
Database of Orthologous Groups More...OrthoDBⁱ	POG093Z013J.

Family and domain databases

Gene3Dⁱ	1.10.1160.10. 1 hit. 3.40.50.620. 2 hits.
HAMAPⁱ	MF_02076. Glu_tRNA_synth_type2. 1 hit.
InterProⁱ	View protein in InterPro IPR004526. Glu-tRNA-synth_arc/euk. IPR000924. Glu/Gln-tRNA-synth. IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl. IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom. IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd. IPR011035. Ribosomal_L25/Gln-tRNA_synth. IPR014729. Rossmann-like_a/b/a_fold.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00749. tRNA-synt_1c. 1 hit. PF03950. tRNA-synt_1c_C. 1 hit.
PRINTSⁱ	PR00987. TRNASYNTHGLU.
SUPFAMⁱ	SSF50715. SSF50715. 1 hit.
TIGRFAMsⁱ	TIGR00463. gltX_arch. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SYE_HALS3
Accessionⁱ	B0R4Z6Primary (citable) accession number: B0R4Z6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
	Last sequence update:	April 8, 2008
	Last modified:	June 7, 2017
	This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB - B0R4Z6 (SYE_HALS3)

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Glutamate--tRNA ligase

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Proteomic databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Motif

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B0R4Z6 (SYE_HALS3)

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Glutamate--tRNA ligase

gltX

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ