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B0R4Z6

- SYE_HALS3

UniProt

B0R4Z6 - SYE_HALS3

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHSAL478009:GJVF-951-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetaseUniRule annotation
    Short name:
    GluRSUniRule annotation
    Gene namesi
    Name:gltXUniRule annotation
    Ordered Locus Names:OE_2652F
    OrganismiHalobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
    Taxonomic identifieri478009 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
    ProteomesiUP000001321: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 586586Glutamate--tRNA ligasePRO_1000090079Add
    BLAST

    Proteomic databases

    PRIDEiB0R4Z6.

    Interactioni

    Protein-protein interaction databases

    STRINGi478009.OE2652F.

    Structurei

    3D structure databases

    ProteinModelPortaliB0R4Z6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi114 – 12411"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000073585.
    KOiK01885.
    OMAiAFRIIDT.

    Family and domain databases

    Gene3Di1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_A. Glu_tRNA_synth_A.
    InterProiIPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF50715. SSF50715. 1 hit.
    TIGRFAMsiTIGR00463. gltX_arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B0R4Z6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDDELRERVR RAAERAALFN ALKHGSDAQV GAIMGPMMGE HPDFRAHGDE    50
    IPGVIAPVIE DVNGMSDDEQ RARLAELAPE DVEELDSEDE GDDHALPALP 100
    NAEAYDEVRM RCAPNPNGPW HVGHARMPSV IGTYKQRYDG SFVVRFDDTD 150
    PETKRPDLDA YDQILEDLSY LGFEADEVLT ASDRVETYYE HARRLIGMGG 200
    AYTCSCPGAE FSDLKNSGEA CPHRDKDPET VADEFEAMVD GEYNSGEMVL 250
    RVKTDITHKN PALRDWVAFR MVDTPHPRDA ASGYRCWPML DFQSGVDDHR 300
    TGVTHIIRGI DLQDSAKRQR FLYEYFGWEY PEVVHWGHVQ LDAYDVAMST 350
    STIKERIAAG ELEGWDDPRA PTMQSIRRRG IRGAAVVDAM VELGTSSSDV 400
    ELAMSAVYAN NRDLVDDTAP RQFLVRDGFE ARGEGPEESH EAVEVPVDDG 450
    PDEATPQVHP EHPDRGDREI PVGERVLVEA TDLPAAGDRV WLKGYGPVRY 500
    DGERFAFLDA DIDIVREEGV DVVQWVPAEH NVDVRLRTMD GDVTGYAEPG 550
    FADRDADEIV QFVRVGFARV DAHRDGGASV AYFTHP 586
    Length:586
    Mass (Da):65,312
    Last modified:April 8, 2008 - v1
    Checksum:iE844ED37F8F46776
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM774415 Genomic DNA. Translation: CAP13811.1.
    RefSeqiWP_010902829.1. NC_010364.1.
    YP_001689159.1. NC_010364.1.

    Genome annotation databases

    EnsemblBacteriaiCAP13811; CAP13811; OE_2652F.
    GeneIDi5952846.
    KEGGihsl:OE2652F.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM774415 Genomic DNA. Translation: CAP13811.1 .
    RefSeqi WP_010902829.1. NC_010364.1.
    YP_001689159.1. NC_010364.1.

    3D structure databases

    ProteinModelPortali B0R4Z6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 478009.OE2652F.

    Proteomic databases

    PRIDEi B0R4Z6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAP13811 ; CAP13811 ; OE_2652F .
    GeneIDi 5952846.
    KEGGi hsl:OE2652F.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000073585.
    KOi K01885.
    OMAi AFRIIDT.

    Enzyme and pathway databases

    BioCyci HSAL478009:GJVF-951-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_A. Glu_tRNA_synth_A.
    InterProi IPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF50715. SSF50715. 1 hit.
    TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Evolution in the laboratory: the genome of Halobacterium salinarum strain R1 compared to that of strain NRC-1."
      Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K., Ruepp A., Soppa J., Tittor J., Oesterhelt D.
      Genomics 91:335-346(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29341 / DSM 671 / R1.

    Entry informationi

    Entry nameiSYE_HALS3
    AccessioniPrimary (citable) accession number: B0R4Z6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3