UniProtKB - B0R4Z6 (SYE_HALS3)
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Protein
Glutamate--tRNA ligase
Gene
gltX
Organism
Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Status
Functioni
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation
Catalytic activityi
ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- glutamate-tRNA ligase activity Source: UniProtKB-EC
GO - Biological processi
- glutamyl-tRNA aminoacylation Source: InterPro
Keywordsi
Molecular function | Aminoacyl-tRNA synthetase, Ligase |
Biological process | Protein biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)Alternative name(s): Glutamyl-tRNA synthetaseUniRule annotation Short name: GluRSUniRule annotation |
Gene namesi | Name:gltXUniRule annotation Ordered Locus Names:OE_2652F |
Organismi | Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) |
Taxonomic identifieri | 478009 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halobacterium › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000090079 | 1 – 586 | Glutamate--tRNA ligaseAdd BLAST | 586 |
Proteomic databases
PRIDEi | B0R4Z6. |
Structurei
3D structure databases
ProteinModelPortali | B0R4Z6. |
SMRi | B0R4Z6. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 114 – 124 | "HIGH" regionUniRule annotationAdd BLAST | 11 |
Sequence similaritiesi
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.UniRule annotation
Phylogenomic databases
HOGENOMi | HOG000073585. |
KOi | K01885. |
OMAi | MRFAPNP. |
OrthoDBi | POG093Z013J. |
Family and domain databases
Gene3Di | 2.40.240.10. 1 hit. 3.40.50.620. 1 hit. |
HAMAPi | MF_02076. Glu_tRNA_synth_type2. 1 hit. |
InterProi | View protein in InterPro IPR004526. Glu-tRNA-synth_arc/euk. IPR000924. Glu/Gln-tRNA-synth. IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom. IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd. IPR020056. Rbsml_L25/Gln-tRNA_synth_N. IPR011035. Ribosomal_L25/Gln-tRNA_synth. IPR014729. Rossmann-like_a/b/a_fold. |
Pfami | View protein in Pfam PF00749. tRNA-synt_1c. 1 hit. PF03950. tRNA-synt_1c_C. 1 hit. |
PRINTSi | PR00987. TRNASYNTHGLU. |
SUPFAMi | SSF50715. SSF50715. 1 hit. |
TIGRFAMsi | TIGR00463. gltX_arch. 1 hit. |
i Sequence
Sequence statusi: Complete.
B0R4Z6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDDELRERVR RAAERAALFN ALKHGSDAQV GAIMGPMMGE HPDFRAHGDE
60 70 80 90 100
IPGVIAPVIE DVNGMSDDEQ RARLAELAPE DVEELDSEDE GDDHALPALP
110 120 130 140 150
NAEAYDEVRM RCAPNPNGPW HVGHARMPSV IGTYKQRYDG SFVVRFDDTD
160 170 180 190 200
PETKRPDLDA YDQILEDLSY LGFEADEVLT ASDRVETYYE HARRLIGMGG
210 220 230 240 250
AYTCSCPGAE FSDLKNSGEA CPHRDKDPET VADEFEAMVD GEYNSGEMVL
260 270 280 290 300
RVKTDITHKN PALRDWVAFR MVDTPHPRDA ASGYRCWPML DFQSGVDDHR
310 320 330 340 350
TGVTHIIRGI DLQDSAKRQR FLYEYFGWEY PEVVHWGHVQ LDAYDVAMST
360 370 380 390 400
STIKERIAAG ELEGWDDPRA PTMQSIRRRG IRGAAVVDAM VELGTSSSDV
410 420 430 440 450
ELAMSAVYAN NRDLVDDTAP RQFLVRDGFE ARGEGPEESH EAVEVPVDDG
460 470 480 490 500
PDEATPQVHP EHPDRGDREI PVGERVLVEA TDLPAAGDRV WLKGYGPVRY
510 520 530 540 550
DGERFAFLDA DIDIVREEGV DVVQWVPAEH NVDVRLRTMD GDVTGYAEPG
560 570 580
FADRDADEIV QFVRVGFARV DAHRDGGASV AYFTHP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM774415 Genomic DNA. Translation: CAP13811.1. |
RefSeqi | WP_010902829.1. NC_010364.1. |
Genome annotation databases
EnsemblBacteriai | CAP13811; CAP13811; OE_2652F. |
GeneIDi | 5952846. |
KEGGi | hsl:OE_2652F. |
Similar proteinsi
Entry informationi
Entry namei | SYE_HALS3 | |
Accessioni | B0R4Z6Primary (citable) accession number: B0R4Z6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 24, 2009 |
Last sequence update: | April 8, 2008 | |
Last modified: | February 28, 2018 | |
This is version 62 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |