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Protein

Cell division protein FtsZ 2

Gene

ftsZ2

Organism
Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. Overexpression causes significant changes in cell morphology (PubMed:8631708).UniRule annotation1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei158 – 1581GTPUniRule annotation
Binding sitei161 – 1611GTPUniRule annotation
Binding sitei204 – 2041GTPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 445GTPUniRule annotation
Nucleotide bindingi127 – 1293GTPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Septation

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHSAL478009:GJVF-189-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZ 2UniRule annotation
Gene namesi
Name:ftsZ2UniRule annotation
Ordered Locus Names:OE_1319R
OrganismiHalobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Taxonomic identifieri478009 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000001321 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Cell division protein FtsZ 2PRO_0000414241Add
BLAST

Proteomic databases

PRIDEiB0R2V3.

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB0R2V3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000049094.
OMAiWGARIQD.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0R2V3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDIVQDALD NAEAEQREMD GDGDGDEFGD PRIVIVGCGG AGNNTVNRLY
60 70 80 90 100
NIGVEGADTV AINTDKQHLK MIKADTKILV GKSLTNGLGA GGDPSMGERA
110 120 130 140 150
TEMAQGTIKE VLGDADLVFV TAGMGGGTGT GAAPVVSKIA KEQGAIVVGM
160 170 180 190 200
VSTPFNVERA RTVKAEEGLE KLREKADSII VLDNNRLLDY VPNLPIGKAF
210 220 230 240 250
SVMDQIIAET VKGISETITQ PSLINLDYAD MTAIMNQGGV AVMLVGETQD
260 270 280 290 300
KNKTNEVVKD AMNHPLLDVD YRGASGGLVH ITGGPDLTLK EAEGIADNIT
310 320 330 340 350
ERLDASANVI WGARIQESYK GKVRVMAIMT GVQSAQVLGP STQKQADKSR
360 370 380 390
RELQDVDSKQ RAADDAGAGG FGGAHSDGGQ DEVEQENGLD VIR
Length:393
Mass (Da):41,318
Last modified:April 8, 2008 - v1
Checksum:i5C482EC36D0000EA
GO

Sequence cautioni

The sequence AAB06191.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM774415 Genomic DNA. Translation: CAP13063.1.
U32860 Genomic DNA. Translation: AAB06191.1. Different initiation.
RefSeqiWP_012289116.1. NC_010364.1.

Genome annotation databases

EnsemblBacteriaiCAP13063; CAP13063; OE_1319R.
GeneIDi5952416.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM774415 Genomic DNA. Translation: CAP13063.1.
U32860 Genomic DNA. Translation: AAB06191.1. Different initiation.
RefSeqiWP_012289116.1. NC_010364.1.

3D structure databases

ProteinModelPortaliB0R2V3.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB0R2V3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAP13063; CAP13063; OE_1319R.
GeneIDi5952416.

Phylogenomic databases

HOGENOMiHOG000049094.
OMAiWGARIQD.

Enzyme and pathway databases

BioCyciHSAL478009:GJVF-189-MONOMER.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of an ftsZ homolog from the archaebacterium Halobacterium salinarium: implications for the evolution of FtsZ and tubulin."
    Margolin W., Wang R., Kumar M.
    J. Bacteriol. 178:1320-1327(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Strain: R1 / S9 / Pho81.
  2. "Evolution in the laboratory: the genome of Halobacterium salinarum strain R1 compared to that of strain NRC-1."
    Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K., Ruepp A., Soppa J., Tittor J., Oesterhelt D.
    Genomics 91:335-346(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29341 / DSM 671 / R1.

Entry informationi

Entry nameiFTSZ2_HALS3
AccessioniPrimary (citable) accession number: B0R2V3
Secondary accession number(s): Q48290, Q9HSK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: April 8, 2008
Last modified: July 6, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.