ID   B0R0B7_MOUSE            Unreviewed;       141 AA.
AC   B0R0B7;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 91.
DE   RecName: Full=Nociceptin receptor {ECO:0000256|ARBA:ARBA00021498};
DE   AltName: Full=Kappa-type 3 opioid receptor {ECO:0000256|ARBA:ARBA00030257};
DE   AltName: Full=Orphanin FQ receptor {ECO:0000256|ARBA:ARBA00030580};
DE   Flags: Fragment;
GN   Name=Oprl1 {ECO:0000313|Ensembl:ENSMUSP00000118664.2,
GN   ECO:0000313|MGI:MGI:97440};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000118664.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000118664.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000118664.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000118664.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000118664.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: G-protein coupled opioid receptor that functions as a
CC       receptor for the endogenous neuropeptide nociceptin. Ligand binding
CC       causes a conformation change that triggers signaling via guanine
CC       nucleotide-binding proteins (G proteins) and modulates the activity of
CC       down-stream effectors. Signaling via G proteins mediates inhibition of
CC       adenylate cyclase activity and calcium channel activity. Arrestins
CC       modulate signaling via G proteins and mediate the activation of
CC       alternative signaling pathways that lead to the activation of MAP
CC       kinases. Plays a role in modulating nociception and the perception of
CC       pain. Plays a role in the regulation of locomotor activity by the
CC       neuropeptide nociceptin. {ECO:0000256|ARBA:ARBA00043899}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; B0R0B7; -.
DR   SMR; B0R0B7; -.
DR   Antibodypedia; 29994; 262 antibodies from 29 providers.
DR   Ensembl; ENSMUST00000148334.8; ENSMUSP00000118664.2; ENSMUSG00000027584.18.
DR   AGR; MGI:97440; -.
DR   MGI; MGI:97440; Oprl1.
DR   VEuPathDB; HostDB:ENSMUSG00000027584; -.
DR   GeneTree; ENSGT00940000160661; -.
DR   HOGENOM; CLU_125283_0_0_1; -.
DR   ChiTaRS; Oprl1; mouse.
DR   Proteomes; UP000000589; Chromosome 2.
DR   Bgee; ENSMUSG00000027584; Expressed in neural tube lateral wall and 128 other cell types or tissues.
DR   ExpressionAtlas; B0R0B7; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0001626; F:nociceptin receptor activity; IEA:InterPro.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR001418; Opioid_rcpt.
DR   InterPro; IPR001420; X_opioid_rcpt.
DR   PANTHER; PTHR24229; NEUROPEPTIDES RECEPTOR; 1.
DR   PANTHER; PTHR24229:SF11; NOCICEPTIN RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00384; OPIOIDR.
DR   PRINTS; PR00547; XOPIOIDR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   4: Predicted;
KW   Behavior {ECO:0000256|ARBA:ARBA00022610};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        45..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        81..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          61..141
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
FT   NON_TER         141
FT                   /evidence="ECO:0000313|Ensembl:ENSMUSP00000118664.2"
SQ   SEQUENCE   141 AA;  15592 MW;  BCB8DF3DD5DE32F2 CRC64;
     MESLFPAPFW EVLYGSHFQG NLSLLNETVP HHLLLNASHS AFLPLGLKVT IVGLYLAVCI
     GGLLGNCLVM HTKMKTATNI YIFNLALADT LVLLTLPFQG TDILLGFWPF GNALCKTVIA
     IDYYNMFTST FTLTAMSVDR Y
//