ID B0R070_MOUSE Unreviewed; 227 AA. AC B0R070; DT 08-APR-2008, integrated into UniProtKB/TrEMBL. DT 08-APR-2008, sequence version 1. DT 27-MAR-2024, entry version 97. DE RecName: Full=dolichyl-phosphate-mannose--protein mannosyltransferase {ECO:0000256|ARBA:ARBA00012839}; DE EC=2.4.1.109 {ECO:0000256|ARBA:ARBA00012839}; DE Flags: Fragment; GN Name=Pomt1 {ECO:0000313|Ensembl:ENSMUSP00000116117.2, GN ECO:0000313|MGI:MGI:2138994}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000116117.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000116117.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000116117.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000116117.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000116117.2}; RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3- CC O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+); CC Xref=Rhea:RHEA:17377, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9527, CC Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:13546, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:29999, ChEBI:CHEBI:57683, ChEBI:CHEBI:58211, CC ChEBI:CHEBI:137321; EC=2.4.1.109; CC Evidence={ECO:0000256|ARBA:ARBA00034032}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = CC 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + CC H(+); Xref=Rhea:RHEA:53396, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9527, CC Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:13547, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:30013, ChEBI:CHEBI:57683, ChEBI:CHEBI:58211, CC ChEBI:CHEBI:137323; EC=2.4.1.109; CC Evidence={ECO:0000256|ARBA:ARBA00033990}; CC -!- PATHWAY: Protein modification; protein glycosylation. CC {ECO:0000256|ARBA:ARBA00004922}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the glycosyltransferase 39 family. CC {ECO:0000256|ARBA:ARBA00007222}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; B0R070; -. DR SMR; B0R070; -. DR MaxQB; B0R070; -. DR ProteomicsDB; 345095; -. DR Antibodypedia; 31602; 215 antibodies from 27 providers. DR Ensembl; ENSMUST00000146485.8; ENSMUSP00000116117.2; ENSMUSG00000039254.17. DR AGR; MGI:2138994; -. DR MGI; MGI:2138994; Pomt1. DR VEuPathDB; HostDB:ENSMUSG00000039254; -. DR GeneTree; ENSGT00940000158049; -. DR UniPathway; UPA00378; -. DR ChiTaRS; Pomt1; mouse. DR Proteomes; UP000000589; Chromosome 2. DR Bgee; ENSMUSG00000039254; Expressed in spermatocyte and 257 other cell types or tissues. DR ExpressionAtlas; B0R070; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004169; F:dolichyl-phosphate-mannose-protein mannosyltransferase activity; IEA:UniProtKB-EC. DR InterPro; IPR027005; GlyclTrfase_39-like. DR InterPro; IPR003342; Glyco_trans_39/83. DR PANTHER; PTHR10050; DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE; 1. DR PANTHER; PTHR10050:SF51; PROTEIN O-MANNOSYL-TRANSFERASE 1; 1. DR Pfam; PF02366; PMT; 1. PE 1: Evidence at protein level; KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0007829|ProteomicsDB:B0R070}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 33..52 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 92..112 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 124..146 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 152..171 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 178..198 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 210..226 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 45..226 FT /note="Glycosyl transferase family 39/83" FT /evidence="ECO:0000259|Pfam:PF02366" FT NON_TER 227 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000116117.2" SQ SEQUENCE 227 AA; 25557 MW; 1C234B5AA3054D65 CRC64; MYTLCLNTTV ILQQGVLPSW LFCKMLRFLK RPLVVTVDIN LNLVALTGLG LLTRLWQLSY PRAVVFDEVY YGQYISFYMK RIFFLDDSGP PFGHMLLALG GWLGGFDGNF LWNRIGAEYS SNVPIWSLRL LPALAGALSV PMAYQIVLEL HFSHGAAIGA ALLMLIENAL ITQSRLMLLE SILIFFNLLA VLSYLKFFNS QTHSPFSVHW WLWLLLTGVS CSCAVGI //