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Protein

Sodium/hydrogen exchanger

Gene

Slc9a6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • axon extension Source: MGI
  • brain-derived neurotrophic factor receptor signaling pathway Source: MGI
  • dendrite extension Source: MGI
  • dendritic spine development Source: MGI
  • neuron projection morphogenesis Source: MGI
  • proton transport Source: MGI
  • regulation of neurotrophin TRK receptor signaling pathway Source: MGI
  • regulation of pH Source: InterPro
  • synapse organization Source: MGI

Keywordsi

Biological processAntiportUniRule annotationSAAS annotation, Ion transport, Sodium transportUniRule annotation, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-MMU-425986. Sodium/Proton exchangers.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchangerUniRule annotation
Gene namesi
Name:Slc9a6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2443511. Slc9a6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei104 – 121HelicalSequence analysisAdd BLAST18
Transmembranei151 – 168HelicalSequence analysisAdd BLAST18
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Transmembranei295 – 317HelicalSequence analysisAdd BLAST23
Transmembranei337 – 361HelicalSequence analysisAdd BLAST25
Transmembranei382 – 403HelicalSequence analysisAdd BLAST22
Transmembranei415 – 437HelicalSequence analysisAdd BLAST23
Transmembranei449 – 468HelicalSequence analysisAdd BLAST20
Transmembranei474 – 495HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

  • axonal spine Source: MGI
  • axon terminus Source: MGI
  • cytoplasmic vesicle Source: MGI
  • dendrite Source: MGI
  • early endosome Source: MGI
  • early endosome membrane Source: MGI
  • endoplasmic reticulum membrane Source: MGI
  • endosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • intracellular membrane-bounded organelle Source: MGI
  • late endosome Source: MGI
  • mitochondrion Source: MGI
  • plasma membrane Source: MGI
  • recycling endosome Source: MGI
  • recycling endosome membrane Source: MGI
  • synapse Source: MGI

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiB0QZV3.
PaxDbiB0QZV3.
PeptideAtlasiB0QZV3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000060681.
ExpressionAtlasiB0QZV3. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliB0QZV3.
SMRiB0QZV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 503Na_H_ExchangerInterPro annotationAdd BLAST424

Sequence similaritiesi

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1965. Eukaryota.
COG0025. LUCA.
GeneTreeiENSGT00760000119074.
HOGENOMiHOG000172307.
HOVERGENiHBG055575.

Family and domain databases

InterProiView protein in InterPro
IPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR002090. Na/H_exchanger_6.
IPR004709. NaH_exchanger.
PANTHERiPTHR10110. PTHR10110. 1 hit.
PfamiView protein in Pfam
PF00999. Na_H_Exchanger. 1 hit.
PRINTSiPR01084. NAHEXCHNGR.
PR01088. NAHEXCHNGR6.
TIGRFAMsiTIGR00840. b_cpa1. 1 hit.

Sequencei

Sequence statusi: Complete.

B0QZV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGARRGWRL APVRRGVCGP RARPLMRPLW LLFAVSFFGW TGALDGSGGT
60 70 80 90 100
TRAMDEEIVS EKQAEESHRQ DSANLLIFIL LLTLTILTIW LFKHRRARFL
110 120 130 140 150
HETGLAMIYG LLVGLVLRYG IHVPSDVNNV TLSCEVQSSP TTLLVTFDPE
160 170 180 190 200
VFFNILLPPI IFYAGYSLKR RHFFRNLGSI LAYAFLGTAI SCFVIGSIMY
210 220 230 240 250
GCVTLMKVTG QLAGDFYFTD CLLFGAIVSA TDPVTVLAIF HELQVDVELY
260 270 280 290 300
ALLFGESVLN DAVAIVLSSS IVAYQPAGDN SHTFDVTAMF KSIGIFLGIF
310 320 330 340 350
SGSFAMGAAT GVVTALVTKF TKLREFQLLE TGLFFLMSWS TFLLAEAWGF
360 370 380 390 400
TGVVAVLFCG ITQAHYTYNN LSTESQHRTK QLFELLNFLA ENFIFSYMGL
410 420 430 440 450
TLFTFQNHVF NPTFVVGAFI AIFLGRAANI YPLSLLLNLG RRSKIGSNFQ
460 470 480 490 500
HMMMFAGLRG AMAFALAIRD TATYARQMMF STTLLIVFFT VWVFGGGTTA
510 520 530 540 550
MLSCLHIRVG VDSDQEHLGV PDNERRTTKA ESAWLFRMWY NFDHNYLKPL
560 570 580 590 600
LTHSGPPLTT TLPACCGPIA RCLTSPQAYE NQEQLKDDDS DLILNDGDIS
610 620 630 640 650
LTYGDSTVNT ESATASAPRR FMGNSSEDAL DRELTFGDHE LVIRGTRLVL
660 670
PMDDSEPALN SLDDTRHSPA
Length:670
Mass (Da):74,228
Last modified:April 8, 2008 - v1
Checksum:iF58983DFE9792463
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC048362 Genomic DNA. No translation available.
AL672085 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000114784; ENSMUSP00000110432; ENSMUSG00000060681.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiB0QZV3_MOUSE
AccessioniPrimary (citable) accession number: B0QZV3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: July 5, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported