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B0QZV3

- B0QZV3_MOUSE

UniProt

B0QZV3 - B0QZV3_MOUSE

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Protein

Sodium/hydrogen exchanger

Gene

Slc9a6

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. sodium:proton antiporter activity Source: InterPro

GO - Biological processi

  1. axon extension Source: MGI
  2. brain-derived neurotrophic factor receptor signaling pathway Source: MGI
  3. dendrite extension Source: MGI
  4. dendritic spine development Source: MGI
  5. neuron projection morphogenesis Source: MGI
  6. proton transport Source: MGI
  7. regulation of neurotrophin TRK receptor signaling pathway Source: MGI
  8. regulation of pH Source: InterPro
  9. synapse organization Source: MGI
Complete GO annotation...

Keywords - Biological processi

AntiportUniRule annotationSAAS annotation, Ion transport, Sodium transportUniRule annotation, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_259261. Sodium/Proton exchangers.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchangerUniRule annotation
Gene namesi
Name:Slc9a6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:2443511. Slc9a6.

Subcellular locationi

GO - Cellular componenti

  1. axonal spine Source: MGI
  2. axon terminus Source: MGI
  3. cytoplasmic vesicle Source: MGI
  4. dendrite Source: MGI
  5. early endosome Source: MGI
  6. endosome Source: MGI
  7. integral component of membrane Source: UniProtKB-KW
  8. late endosome Source: MGI
  9. mitochondrion Source: MGI
  10. plasma membrane Source: MGI
  11. recycling endosome Source: MGI
  12. synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

ExpressionAtlasiB0QZV3. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliB0QZV3.
SMRiB0QZV3. Positions 220-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119074.
HOGENOMiHOG000172307.
HOVERGENiHBG055575.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR002090. Na/H_exchanger_6.
IPR004709. NaH_exchanger.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 1 hit.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
PRINTSiPR01084. NAHEXCHNGR.
PR01088. NAHEXCHNGR6.
TIGRFAMsiTIGR00840. b_cpa1. 1 hit.

Sequencei

Sequence statusi: Complete.

B0QZV3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGARRGWRL APVRRGVCGP RARPLMRPLW LLFAVSFFGW TGALDGSGGT
60 70 80 90 100
TRAMDEEIVS EKQAEESHRQ DSANLLIFIL LLTLTILTIW LFKHRRARFL
110 120 130 140 150
HETGLAMIYG LLVGLVLRYG IHVPSDVNNV TLSCEVQSSP TTLLVTFDPE
160 170 180 190 200
VFFNILLPPI IFYAGYSLKR RHFFRNLGSI LAYAFLGTAI SCFVIGSIMY
210 220 230 240 250
GCVTLMKVTG QLAGDFYFTD CLLFGAIVSA TDPVTVLAIF HELQVDVELY
260 270 280 290 300
ALLFGESVLN DAVAIVLSSS IVAYQPAGDN SHTFDVTAMF KSIGIFLGIF
310 320 330 340 350
SGSFAMGAAT GVVTALVTKF TKLREFQLLE TGLFFLMSWS TFLLAEAWGF
360 370 380 390 400
TGVVAVLFCG ITQAHYTYNN LSTESQHRTK QLFELLNFLA ENFIFSYMGL
410 420 430 440 450
TLFTFQNHVF NPTFVVGAFI AIFLGRAANI YPLSLLLNLG RRSKIGSNFQ
460 470 480 490 500
HMMMFAGLRG AMAFALAIRD TATYARQMMF STTLLIVFFT VWVFGGGTTA
510 520 530 540 550
MLSCLHIRVG VDSDQEHLGV PDNERRTTKA ESAWLFRMWY NFDHNYLKPL
560 570 580 590 600
LTHSGPPLTT TLPACCGPIA RCLTSPQAYE NQEQLKDDDS DLILNDGDIS
610 620 630 640 650
LTYGDSTVNT ESATASAPRR FMGNSSEDAL DRELTFGDHE LVIRGTRLVL
660 670
PMDDSEPALN SLDDTRHSPA
Length:670
Mass (Da):74,228
Last modified:April 8, 2008 - v1
Checksum:iF58983DFE9792463
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC048362 Genomic DNA. No translation available.
AL672085 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000114784; ENSMUSP00000110432; ENSMUSG00000060681.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC048362 Genomic DNA. No translation available.
AL672085 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali B0QZV3.
SMRi B0QZV3. Positions 220-267.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000114784 ; ENSMUSP00000110432 ; ENSMUSG00000060681 .

Organism-specific databases

MGIi MGI:2443511. Slc9a6.

Phylogenomic databases

GeneTreei ENSGT00760000119074.
HOGENOMi HOG000172307.
HOVERGENi HBG055575.

Enzyme and pathway databases

Reactomei REACT_259261. Sodium/Proton exchangers.

Miscellaneous databases

NextBioi 35545469.
SOURCEi Search...

Gene expression databases

ExpressionAtlasi B0QZV3. baseline and differential.

Family and domain databases

InterProi IPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR002090. Na/H_exchanger_6.
IPR004709. NaH_exchanger.
[Graphical view ]
PANTHERi PTHR10110. PTHR10110. 1 hit.
Pfami PF00999. Na_H_Exchanger. 1 hit.
[Graphical view ]
PRINTSi PR01084. NAHEXCHNGR.
PR01088. NAHEXCHNGR6.
TIGRFAMsi TIGR00840. b_cpa1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB0QZV3_MOUSE
AccessioniPrimary (citable) accession number: B0QZV3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 26, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3