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Protein

Sodium/hydrogen exchanger

Gene

Slc9a6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • axon extension Source: MGI
  • brain-derived neurotrophic factor receptor signaling pathway Source: MGI
  • dendrite extension Source: MGI
  • dendritic spine development Source: MGI
  • neuron projection morphogenesis Source: MGI
  • regulation of neurotrophin TRK receptor signaling pathway Source: MGI
  • regulation of pH Source: InterPro
  • synapse organization Source: MGI

Keywordsi

Biological processAntiportUniRule annotationSAAS annotation, Ion transport, Sodium transportUniRule annotation, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-MMU-425986 Sodium/Proton exchangers

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchangerUniRule annotation
Gene namesi
Name:Slc9a6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2443511 Slc9a6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei104 – 121HelicalSequence analysisAdd BLAST18
Transmembranei151 – 168HelicalSequence analysisAdd BLAST18
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Transmembranei295 – 317HelicalSequence analysisAdd BLAST23
Transmembranei337 – 361HelicalSequence analysisAdd BLAST25
Transmembranei382 – 403HelicalSequence analysisAdd BLAST22
Transmembranei415 – 437HelicalSequence analysisAdd BLAST23
Transmembranei449 – 468HelicalSequence analysisAdd BLAST20
Transmembranei474 – 495HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiB0QZV3
PeptideAtlasiB0QZV3

Expressioni

Gene expression databases

BgeeiENSMUSG00000060681
ExpressionAtlasiB0QZV3 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliB0QZV3
SMRiB0QZV3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 503Na_H_ExchangerInterPro annotationAdd BLAST424

Sequence similaritiesi

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1965 Eukaryota
COG0025 LUCA
GeneTreeiENSGT00760000119074
HOGENOMiHOG000172307
HOVERGENiHBG055575

Family and domain databases

InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR018422 Cation/H_exchanger_CPA1
IPR002090 Na/H_exchanger_6
IPR004709 NaH_exchanger
PANTHERiPTHR10110 PTHR10110, 2 hits
PfamiView protein in Pfam
PF00999 Na_H_Exchanger, 1 hit
PRINTSiPR01084 NAHEXCHNGR
PR01088 NAHEXCHNGR6
TIGRFAMsiTIGR00840 b_cpa1, 1 hit

Sequencei

Sequence statusi: Complete.

B0QZV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGARRGWRL APVRRGVCGP RARPLMRPLW LLFAVSFFGW TGALDGSGGT
60 70 80 90 100
TRAMDEEIVS EKQAEESHRQ DSANLLIFIL LLTLTILTIW LFKHRRARFL
110 120 130 140 150
HETGLAMIYG LLVGLVLRYG IHVPSDVNNV TLSCEVQSSP TTLLVTFDPE
160 170 180 190 200
VFFNILLPPI IFYAGYSLKR RHFFRNLGSI LAYAFLGTAI SCFVIGSIMY
210 220 230 240 250
GCVTLMKVTG QLAGDFYFTD CLLFGAIVSA TDPVTVLAIF HELQVDVELY
260 270 280 290 300
ALLFGESVLN DAVAIVLSSS IVAYQPAGDN SHTFDVTAMF KSIGIFLGIF
310 320 330 340 350
SGSFAMGAAT GVVTALVTKF TKLREFQLLE TGLFFLMSWS TFLLAEAWGF
360 370 380 390 400
TGVVAVLFCG ITQAHYTYNN LSTESQHRTK QLFELLNFLA ENFIFSYMGL
410 420 430 440 450
TLFTFQNHVF NPTFVVGAFI AIFLGRAANI YPLSLLLNLG RRSKIGSNFQ
460 470 480 490 500
HMMMFAGLRG AMAFALAIRD TATYARQMMF STTLLIVFFT VWVFGGGTTA
510 520 530 540 550
MLSCLHIRVG VDSDQEHLGV PDNERRTTKA ESAWLFRMWY NFDHNYLKPL
560 570 580 590 600
LTHSGPPLTT TLPACCGPIA RCLTSPQAYE NQEQLKDDDS DLILNDGDIS
610 620 630 640 650
LTYGDSTVNT ESATASAPRR FMGNSSEDAL DRELTFGDHE LVIRGTRLVL
660 670
PMDDSEPALN SLDDTRHSPA
Length:670
Mass (Da):74,228
Last modified:April 8, 2008 - v1
Checksum:iF58983DFE9792463
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC048362 Genomic DNA No translation available.
AL672085 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000114784; ENSMUSP00000110432; ENSMUSG00000060681

Similar proteinsi

Entry informationi

Entry nameiB0QZV3_MOUSE
AccessioniPrimary (citable) accession number: B0QZV3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: April 25, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health