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B0QZL5

- B0QZL5_MOUSE

UniProt

B0QZL5 - B0QZL5_MOUSE

Protein
Submitted name:

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Gene

Pik3cd

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. 1-phosphatidylinositol-3-kinase activity Source: RefGenome
    2. 1-phosphatidylinositol-4-phosphate 3-kinase activity Source: RefGenome
    3. ATP binding Source: UniProtKB-KW
    4. phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: RefGenome

    GO - Biological processi

    1. B cell activation Source: MGI
    2. B cell homeostasis Source: MGI
    3. cell surface receptor signaling pathway Source: MGI
    4. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
    5. phosphatidylinositol-mediated signaling Source: InterPro

    Keywords - Molecular functioni

    KinaseSAAS annotation, Transferase

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformImported
    Gene namesi
    Name:Pik3cdImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1098211. Pik3cd.

    Subcellular locationi

    GO - Cellular componenti

    1. phosphatidylinositol 3-kinase complex Source: RefGenome
    2. plasma membrane Source: RefGenome

    Expressioni

    Gene expression databases

    ArrayExpressiB0QZL5.

    Structurei

    3D structure databases

    ProteinModelPortaliB0QZL5.
    SMRiB0QZL5. Positions 109-1023.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 PIK helical domain.
    Contains PI3K/PI4K domain.SAAS annotation
    Contains PIK helical domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00620000087742.
    HOGENOMiHOG000252911.
    HOVERGENiHBG052721.

    Family and domain databases

    Gene3Di1.10.1070.11. 1 hit.
    1.25.40.70. 1 hit.
    2.60.40.150. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR003113. PI3K_adapt-bd_dom.
    IPR002420. PI3K_C2_dom.
    IPR000341. PI3K_Ras-bd_dom.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PANTHERiPTHR10048. PTHR10048. 1 hit.
    PfamiPF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF02192. PI3K_p85B. 1 hit.
    PF00794. PI3K_rbd. 1 hit.
    PF00613. PI3Ka. 1 hit.
    [Graphical view]
    SMARTiSM00142. PI3K_C2. 1 hit.
    SM00143. PI3K_p85B. 1 hit.
    SM00144. PI3K_rbd. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF49562. SSF49562. 1 hit.
    SSF54236. SSF54236. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51544. PI3K_ABD. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51546. PI3K_RBD. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0QZL5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPGVDCPME FWTKEESQSV VVDFLLPTGV YLNFPVSRNA NLSTIKQVLW     50
    HRAQYEPLFH MLSDPEAYVF TCVNQTAEQQ ELEDEQRRLC DIQPFLPVLR 100
    LVAREGDRVK KLINSQISLL IGKGLHEFDS LRDPEVNDFR TKMRQFCEEA 150
    AAHRQQLGWV EWLQYSFPLQ LEPSARGWRA GLLRVSNRAL LVNVKFEGSE 200
    ESFTFQVSTK DMPLALMACA LRKKATVFRQ PLVEQPEEYA LQVNGRHEYL 250
    YGNYPLCHFQ YICSCLHSGL TPHLTMVHSS SILAMRDEQS NPAPQVQKPR 300
    AKPPPIPAKK PSSVSLWSLE QPFSIELIEG RKVNADERMK AGLFHGNEML 350
    CKTVSSSEVN VCSEPVWKQR LEFDISVCDL PRMARLCFAL YAVVEKAKKA 400
    RSTKKKSKKA DCPIAWANLM LFDYKDQLKT GERCLYMWPS VPDEKGELLN 450
    PAGTVRGNPN TESAAALVIY LPEVAPHPVY FPALEKILEL GRHGERGRIT 500
    EEEQLQLREI LERRGSGELY EHEKDLVWKM RHEVQEHFPE ALARLLLVTK 550
    WNKHEDVAQM LYLLCSWPEL PVLSALELLD FSFPDCYVGS FAIKSLRKLT 600
    DDELFQYLLQ LVQVLKYESY LDCELTKFLL GRALANRKIG HFLFWHLRSE 650
    MHVPSVALRF GLIMEAYCRG STHHMKVLMK QGEALSKLKA LNDFVKVSSQ 700
    KTTKPQTKEM MHMCMRQETY MEALSHLQSP LDPSTLLEEV CVEQCTFMDS 750
    KMKPLWIMYS SEEAGSAGNV GIIFKNGDDL RQDMLTLQMI QLMDVLWKQE 800
    GLDLRMTPYG CLPTGDRTGL IEVVLHSDTI ANIQLNKSNM AATAAFNKDA 850
    LLNWLKSKNP GEALDRAIEE FTLSCAGYCV ATYVLGIGDR HSDNIMIRES 900
    GQLFHIDFGH FLGNFKTKFG INRERVPFIL TYDFVHVIQQ GKTNNSEKFE 950
    RFRGYCERAY TILRRHGLLF LHLFALMRAA GLPELSCSKD IQYLKDSLAL 1000
    GKTEEEALKH FRVKFNEALR ESWKTKVNWL AHNVSKDNRQ 1040
    Length:1,040
    Mass (Da):119,401
    Last modified:April 8, 2008 - v1
    Checksum:i379C09DF0C684208
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL607078 Genomic DNA. No translation available.
    AL626808 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000122059; ENSMUSP00000113844; ENSMUSG00000039936.
    UCSCiuc012dpt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL607078 Genomic DNA. No translation available.
    AL626808 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali B0QZL5.
    SMRi B0QZL5. Positions 109-1023.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000122059 ; ENSMUSP00000113844 ; ENSMUSG00000039936 .
    UCSCi uc012dpt.1. mouse.

    Organism-specific databases

    MGIi MGI:1098211. Pik3cd.

    Phylogenomic databases

    GeneTreei ENSGT00620000087742.
    HOGENOMi HOG000252911.
    HOVERGENi HBG052721.

    Miscellaneous databases

    ChiTaRSi PIK3CD. mouse.
    NextBioi 35545435.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi B0QZL5.

    Family and domain databases

    Gene3Di 1.10.1070.11. 1 hit.
    1.25.40.70. 1 hit.
    2.60.40.150. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR003113. PI3K_adapt-bd_dom.
    IPR002420. PI3K_C2_dom.
    IPR000341. PI3K_Ras-bd_dom.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    PANTHERi PTHR10048. PTHR10048. 1 hit.
    Pfami PF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF02192. PI3K_p85B. 1 hit.
    PF00794. PI3K_rbd. 1 hit.
    PF00613. PI3Ka. 1 hit.
    [Graphical view ]
    SMARTi SM00142. PI3K_C2. 1 hit.
    SM00143. PI3K_p85B. 1 hit.
    SM00144. PI3K_rbd. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF49562. SSF49562. 1 hit.
    SSF54236. SSF54236. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51544. PI3K_ABD. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51546. PI3K_RBD. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiB0QZL5_MOUSE
    AccessioniPrimary (citable) accession number: B0QZL5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 8, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3