B0QZL5 (B0QZL5_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Ensembl ENSMUSP00000113844

Gene names

Name:

Pik3cd Ensembl ENSMUSP00000113844 MGI 1098211

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000113844

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1040 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 1 PI3K/PI4K domain. SAAS SAAS018936 Contains 1 PIK helical domain. SAAS SAAS018936
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000113844

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS008973 Nucleotide-binding
Molecular function	Kinase SAAS SAAS018936 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	B cell activation Inferred from mutant phenotype PubMed 12235209. Source: MGI B cell homeostasis Inferred from mutant phenotype PubMed 12235209. Source: MGI cell surface receptor signaling pathway Inferred from mutant phenotype PubMed 12235209. Source: MGI phosphatidylinositol-mediated signaling Inferred from electronic annotation. Source: InterPro
Cellular_component	phosphatidylinositol 3-kinase complex Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	1-phosphatidylinositol-3-kinase activity Inferred from Biological aspect of Ancestor. Source: RefGenome 1-phosphatidylinositol-4-phosphate 3-kinase activity Inferred from Biological aspect of Ancestor. Source: RefGenome ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphatidylinositol-4,5-bisphosphate 3-kinase activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B0QZL5 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 379C09DF0C684208	FASTA	1,040	119,401
	10 20 30 40 50 60 MPPGVDCPME FWTKEESQSV VVDFLLPTGV YLNFPVSRNA NLSTIKQVLW HRAQYEPLFH 70 80 90 100 110 120 MLSDPEAYVF TCVNQTAEQQ ELEDEQRRLC DIQPFLPVLR LVAREGDRVK KLINSQISLL 130 140 150 160 170 180 IGKGLHEFDS LRDPEVNDFR TKMRQFCEEA AAHRQQLGWV EWLQYSFPLQ LEPSARGWRA 190 200 210 220 230 240 GLLRVSNRAL LVNVKFEGSE ESFTFQVSTK DMPLALMACA LRKKATVFRQ PLVEQPEEYA 250 260 270 280 290 300 LQVNGRHEYL YGNYPLCHFQ YICSCLHSGL TPHLTMVHSS SILAMRDEQS NPAPQVQKPR 310 320 330 340 350 360 AKPPPIPAKK PSSVSLWSLE QPFSIELIEG RKVNADERMK AGLFHGNEML CKTVSSSEVN 370 380 390 400 410 420 VCSEPVWKQR LEFDISVCDL PRMARLCFAL YAVVEKAKKA RSTKKKSKKA DCPIAWANLM 430 440 450 460 470 480 LFDYKDQLKT GERCLYMWPS VPDEKGELLN PAGTVRGNPN TESAAALVIY LPEVAPHPVY 490 500 510 520 530 540 FPALEKILEL GRHGERGRIT EEEQLQLREI LERRGSGELY EHEKDLVWKM RHEVQEHFPE 550 560 570 580 590 600 ALARLLLVTK WNKHEDVAQM LYLLCSWPEL PVLSALELLD FSFPDCYVGS FAIKSLRKLT 610 620 630 640 650 660 DDELFQYLLQ LVQVLKYESY LDCELTKFLL GRALANRKIG HFLFWHLRSE MHVPSVALRF 670 680 690 700 710 720 GLIMEAYCRG STHHMKVLMK QGEALSKLKA LNDFVKVSSQ KTTKPQTKEM MHMCMRQETY 730 740 750 760 770 780 MEALSHLQSP LDPSTLLEEV CVEQCTFMDS KMKPLWIMYS SEEAGSAGNV GIIFKNGDDL 790 800 810 820 830 840 RQDMLTLQMI QLMDVLWKQE GLDLRMTPYG CLPTGDRTGL IEVVLHSDTI ANIQLNKSNM 850 860 870 880 890 900 AATAAFNKDA LLNWLKSKNP GEALDRAIEE FTLSCAGYCV ATYVLGIGDR HSDNIMIRES 910 920 930 940 950 960 GQLFHIDFGH FLGNFKTKFG INRERVPFIL TYDFVHVIQQ GKTNNSEKFE RFRGYCERAY 970 980 990 1000 1010 1020 TILRRHGLLF LHLFALMRAA GLPELSCSKD IQYLKDSLAL GKTEEEALKH FRVKFNEALR 1030 1040 ESWKTKVNWL AHNVSKDNRQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000113844.
[2]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000113844.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL607078 Genomic DNA. No translation available. AL626808 Genomic DNA. No translation available.
IPI	IPI00885697.
UniGene	Mm.229108.
3D structure databases
ProteinModelPortal	B0QZL5.
SMR	B0QZL5. Positions 20-102, 109-1023.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000122059; ENSMUSP00000113844; ENSMUSG00000039936.
UCSC	uc012dpt.1. mouse.
Organism-specific databases
MGI	MGI:1098211. Pik3cd.
Phylogenomic databases
GeneTree	ENSGT00620000087742.
HOGENOM	HOG000252911.
HOVERGEN	HBG052721.
Gene expression databases
ArrayExpress	B0QZL5.
Family and domain databases
Gene3D	1.10.1070.11. 1 hit. 1.25.40.70. 1 hit.
InterPro	IPR016024. ARM-type_fold. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR011009. Kinase-like_dom. IPR000403. PI3/4_kinase_cat_dom. IPR018936. PI3/4_kinase_CS. IPR003113. PI3K_adapt-bd_dom. IPR002420. PI3K_C2_dom. IPR000341. PI3K_Ras-bd_dom. IPR015433. PI_Kinase. IPR001263. PInositide-3_kin_accessory_dom. [Graphical view]
PANTHER	PTHR10048. PTHR10048. 1 hit.
Pfam	PF00454. PI3_PI4_kinase. 1 hit. PF00792. PI3K_C2. 1 hit. PF02192. PI3K_p85B. 1 hit. PF00794. PI3K_rbd. 1 hit. PF00613. PI3Ka. 1 hit. [Graphical view]
SMART	SM00142. PI3K_C2. 1 hit. SM00143. PI3K_p85B. 1 hit. SM00144. PI3K_rbd. 1 hit. SM00145. PI3Ka. 1 hit. SM00146. PI3Kc. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit. SSF49562. C2_CaLB. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS00915. PI3_4_KINASE_1. 1 hit. PS00916. PI3_4_KINASE_2. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. PS51544. PI3K_ABD. 1 hit. PS51547. PI3K_C2. 1 hit. PS51546. PI3K_RBD. 1 hit. PS51545. PIK_HELICAL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PIK3CD. mouse.
NextBio	35545435.
SOURCE	Search...

Entry information

Entry name

B0QZL5_MOUSE

Accession

Primary (citable) accession number: B0QZL5

Entry history

Integrated into UniProtKB/TrEMBL:	April 8, 2008
Last sequence update:	April 8, 2008
Last modified:	May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)