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B0QZL5

- B0QZL5_MOUSE

UniProt

B0QZL5 - B0QZL5_MOUSE

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Protein
Submitted name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Gene
Pik3cd
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: RefGenome
  2. 1-phosphatidylinositol-4-phosphate 3-kinase activity Source: RefGenome
  3. ATP binding Source: UniProtKB-KW
  4. phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: RefGenome

GO - Biological processi

  1. B cell activation Source: MGI
  2. B cell homeostasis Source: MGI
  3. cell surface receptor signaling pathway Source: MGI
  4. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
  5. phosphatidylinositol-mediated signaling Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotations, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotations, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformImported
Gene namesi
Name:Pik3cdImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1098211. Pik3cd.

Subcellular locationi

GO - Cellular componenti

  1. phosphatidylinositol 3-kinase complex Source: RefGenome
  2. plasma membrane Source: RefGenome
Complete GO annotation...

Expressioni

Gene expression databases

ArrayExpressiB0QZL5.

Structurei

3D structure databases

ProteinModelPortaliB0QZL5.
SMRiB0QZL5. Positions 109-1023.

Family & Domainsi

Sequence similaritiesi

Contains 1 PIK helical domain.
Contains PI3K/PI4K domain.SAAS annotations
Contains PIK helical domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00620000087742.
HOGENOMiHOG000252911.
HOVERGENiHBG052721.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTiSM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0QZL5-1 [UniParc]FASTAAdd to Basket

« Hide

MPPGVDCPME FWTKEESQSV VVDFLLPTGV YLNFPVSRNA NLSTIKQVLW     50
HRAQYEPLFH MLSDPEAYVF TCVNQTAEQQ ELEDEQRRLC DIQPFLPVLR 100
LVAREGDRVK KLINSQISLL IGKGLHEFDS LRDPEVNDFR TKMRQFCEEA 150
AAHRQQLGWV EWLQYSFPLQ LEPSARGWRA GLLRVSNRAL LVNVKFEGSE 200
ESFTFQVSTK DMPLALMACA LRKKATVFRQ PLVEQPEEYA LQVNGRHEYL 250
YGNYPLCHFQ YICSCLHSGL TPHLTMVHSS SILAMRDEQS NPAPQVQKPR 300
AKPPPIPAKK PSSVSLWSLE QPFSIELIEG RKVNADERMK AGLFHGNEML 350
CKTVSSSEVN VCSEPVWKQR LEFDISVCDL PRMARLCFAL YAVVEKAKKA 400
RSTKKKSKKA DCPIAWANLM LFDYKDQLKT GERCLYMWPS VPDEKGELLN 450
PAGTVRGNPN TESAAALVIY LPEVAPHPVY FPALEKILEL GRHGERGRIT 500
EEEQLQLREI LERRGSGELY EHEKDLVWKM RHEVQEHFPE ALARLLLVTK 550
WNKHEDVAQM LYLLCSWPEL PVLSALELLD FSFPDCYVGS FAIKSLRKLT 600
DDELFQYLLQ LVQVLKYESY LDCELTKFLL GRALANRKIG HFLFWHLRSE 650
MHVPSVALRF GLIMEAYCRG STHHMKVLMK QGEALSKLKA LNDFVKVSSQ 700
KTTKPQTKEM MHMCMRQETY MEALSHLQSP LDPSTLLEEV CVEQCTFMDS 750
KMKPLWIMYS SEEAGSAGNV GIIFKNGDDL RQDMLTLQMI QLMDVLWKQE 800
GLDLRMTPYG CLPTGDRTGL IEVVLHSDTI ANIQLNKSNM AATAAFNKDA 850
LLNWLKSKNP GEALDRAIEE FTLSCAGYCV ATYVLGIGDR HSDNIMIRES 900
GQLFHIDFGH FLGNFKTKFG INRERVPFIL TYDFVHVIQQ GKTNNSEKFE 950
RFRGYCERAY TILRRHGLLF LHLFALMRAA GLPELSCSKD IQYLKDSLAL 1000
GKTEEEALKH FRVKFNEALR ESWKTKVNWL AHNVSKDNRQ 1040
Length:1,040
Mass (Da):119,401
Last modified:April 8, 2008 - v1
Checksum:i379C09DF0C684208
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL607078 Genomic DNA. No translation available.
AL626808 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000122059; ENSMUSP00000113844; ENSMUSG00000039936.
UCSCiuc012dpt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL607078 Genomic DNA. No translation available.
AL626808 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali B0QZL5.
SMRi B0QZL5. Positions 109-1023.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000122059 ; ENSMUSP00000113844 ; ENSMUSG00000039936 .
UCSCi uc012dpt.1. mouse.

Organism-specific databases

MGIi MGI:1098211. Pik3cd.

Phylogenomic databases

GeneTreei ENSGT00620000087742.
HOGENOMi HOG000252911.
HOVERGENi HBG052721.

Miscellaneous databases

ChiTaRSi PIK3CD. mouse.
NextBioi 35545435.
SOURCEi Search...

Gene expression databases

ArrayExpressi B0QZL5.

Family and domain databases

Gene3Di 1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
PANTHERi PTHR10048. PTHR10048. 1 hit.
Pfami PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view ]
SMARTi SM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB0QZL5_MOUSE
AccessioniPrimary (citable) accession number: B0QZL5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: July 9, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi