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Protein

SUMO-conjugating enzyme

Gene

UBE2I

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + SUMO + protein lysine = AMP + diphosphate + protein N-SUMOyllysine.UniRule annotation

Pathwayi: protein sumoylation

This protein is involved in the pathway protein sumoylation, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway protein sumoylation and in Protein modification.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathwayUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiB0QYN7.
UniPathwayiUPA00886.

Names & Taxonomyi

Protein namesi
Recommended name:
SUMO-conjugating enzymeUniRule annotation (EC:6.3.2.-UniRule annotation)
Gene namesi
Name:UBE2IImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:12485. UBE2I.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiB0QYN7.
PeptideAtlasiB0QYN7.
PRIDEiB0QYN7.

Expressioni

Gene expression databases

BgeeiENSG00000103275.
ExpressionAtlasiB0QYN7. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000324897.

Structurei

3D structure databases

ProteinModelPortaliB0QYN7.
SMRiB0QYN7. Positions 1-137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 137131UBIQUITIN_CONJUGAT_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0424. Eukaryota.
COG5078. LUCA.
GeneTreeiENSGT00550000075088.
HOGENOMiHOG000233454.
HOVERGENiHBG063308.
OrthoDBiEOG091G0NAK.
PhylomeDBiB0QYN7.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR027230. Ubc9.
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PANTHERiPTHR24067:SF51. PTHR24067:SF51. 1 hit.
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0QYN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGIALSRLA QERKAWRKDH PFGFVAVPTK NPDGTMNLMN WECAIPGKKG
60 70 80 90 100
TPWEGGLFKL RMLFKDDYPS SPPKCKFEPP LFHPNVYPSG TVCLSILEED
110 120 130 140 150
KDWRPAITIK QILLGIQELL NEPNIQDPAQ AEAYTIYWLV AALAPLVAAP
160 170 180
PRPSQGRLAG REWRTQAHPT DSQGPRLCGE GRGA
Length:184
Mass (Da):20,458
Last modified:April 8, 2008 - v1
Checksum:iAD786FF443DC3A26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120498 Genomic DNA. No translation available.
AL031714 Genomic DNA. No translation available.
RefSeqiXP_005255597.1. XM_005255540.2.
XP_005255598.1. XM_005255541.4.
XP_011520946.1. XM_011522644.2.
XP_011520947.1. XM_011522645.1.
UniGeneiHs.302903.

Genome annotation databases

EnsembliENST00000402301; ENSP00000384361; ENSG00000103275.
GeneIDi7329.
UCSCiuc002clh.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120498 Genomic DNA. No translation available.
AL031714 Genomic DNA. No translation available.
RefSeqiXP_005255597.1. XM_005255540.2.
XP_005255598.1. XM_005255541.4.
XP_011520946.1. XM_011522644.2.
XP_011520947.1. XM_011522645.1.
UniGeneiHs.302903.

3D structure databases

ProteinModelPortaliB0QYN7.
SMRiB0QYN7. Positions 1-137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000324897.

Proteomic databases

PaxDbiB0QYN7.
PeptideAtlasiB0QYN7.
PRIDEiB0QYN7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000402301; ENSP00000384361; ENSG00000103275.
GeneIDi7329.
UCSCiuc002clh.2. human.

Organism-specific databases

CTDi7329.
HGNCiHGNC:12485. UBE2I.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0424. Eukaryota.
COG5078. LUCA.
GeneTreeiENSGT00550000075088.
HOGENOMiHOG000233454.
HOVERGENiHBG063308.
OrthoDBiEOG091G0NAK.
PhylomeDBiB0QYN7.

Enzyme and pathway databases

UniPathwayiUPA00886.
SignaLinkiB0QYN7.

Miscellaneous databases

ChiTaRSiUBE2I. human.
GenomeRNAii7329.

Gene expression databases

BgeeiENSG00000103275.
ExpressionAtlasiB0QYN7. baseline and differential.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR027230. Ubc9.
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PANTHERiPTHR24067:SF51. PTHR24067:SF51. 1 hit.
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB0QYN7_HUMAN
AccessioniPrimary (citable) accession number: B0QYN7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.