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Protein

Eukaryotic translation initiation factor 3 subunit L

Gene

EIF3L

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factorUniRule annotationImported

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit LUniRule annotation
Short name:
eIF3lUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 6-interacting proteinUniRule annotation
Eukaryotic translation initiation factor 3 subunit E-interacting proteinUniRule annotation
Gene namesi
Name:EIF3LUniRule annotationImported
Synonyms:EIF3EIPUniRule annotation, EIF3S6IPUniRule annotationImported
ORF Names:hCG_41840Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:18138. EIF3L.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100129.

PTM / Processingi

Proteomic databases

MaxQBiB0QY90.
PeptideAtlasiB0QY90.
PRIDEiB0QY90.

Expressioni

Gene expression databases

BgeeiENSG00000100129.
ExpressionAtlasiB0QY90. baseline and differential.

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RRN3.UniRule annotation

Protein-protein interaction databases

STRINGi9606.ENSP00000416892.

Structurei

3D structure databases

ProteinModelPortaliB0QY90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-3 subunit L family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3677. Eukaryota.
ENOG410XPJT. LUCA.
GeneTreeiENSGT00390000000411.
HOGENOMiHOG000265377.
HOVERGENiHBG001289.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
HAMAPiMF_03011. eIF3l. 1 hit.
InterProiIPR019382. eIF3l.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR13242. PTHR13242. 1 hit.
PfamiPF10255. Paf67. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.

Sequencei

Sequence statusi: Complete.

B0QY90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYRPVVSPV MSLTRRCMRS RTSMRTDAVF LILYKELYYR HIYAKVSGGP
60 70 80 90 100
SLEQRFESYY NYCNLFNYIL NADGPAPLEL PNQWLWDIID EFIYQFQSFS
110 120 130 140 150
QYRCKTAKKS EEEIDFLRSN PKIWNVHSVL NVLHSLVDKS NINRQLEVYT
160 170 180 190 200
SGGDPESVAG EYGRHSLYKM LGYFSLVGLL RLHSLLGDYY QAIKVLENIE
210 220 230 240 250
LNKKSMYSRV PECQVTTYYY VGFAYLMMRR YQDAIRVFAN ILLYIQRTKS
260 270 280 290 300
MFQRTTYKYE MINKQNEQMH ALLAIALTMY PMRIDESIHL QLREKYGDKM
310 320 330 340 350
LRMQKGDPQV YEELFSYSCP KFLSPVVPNY DNVHPNYHKE PFLQQLKVFS
360 370 380 390 400
DEVQQQAQLS TIRSFLKLYT TMPVAKLAGF LDLTEQEFRI QLLVFKHKMK
410 420 430 440 450
NLVWTSGISA LDGEFQSASE VDFYIDKDMI HIADTKVARR YGDFFIRQIH
460
KFEELNRTLK KMGQRP
Length:466
Mass (Da):55,162
Last modified:April 8, 2008 - v1
Checksum:i221B53F30BF4B578
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022311 Genomic DNA. No translation available.
Z97630 Genomic DNA. No translation available.
AK093540 mRNA. Translation: BAG52737.1.
CH471095 Genomic DNA. Translation: EAW60195.1.
CH471095 Genomic DNA. Translation: EAW60196.1.
RefSeqiXP_005261682.1. XM_005261625.1.
UniGeneiHs.446852.

Genome annotation databases

EnsembliENST00000406934; ENSP00000384634; ENSG00000100129.
GeneIDi51386.
UCSCiuc062ebe.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022311 Genomic DNA. No translation available.
Z97630 Genomic DNA. No translation available.
AK093540 mRNA. Translation: BAG52737.1.
CH471095 Genomic DNA. Translation: EAW60195.1.
CH471095 Genomic DNA. Translation: EAW60196.1.
RefSeqiXP_005261682.1. XM_005261625.1.
UniGeneiHs.446852.

3D structure databases

ProteinModelPortaliB0QY90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000416892.

Proteomic databases

MaxQBiB0QY90.
PeptideAtlasiB0QY90.
PRIDEiB0QY90.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000406934; ENSP00000384634; ENSG00000100129.
GeneIDi51386.
UCSCiuc062ebe.1. human.

Organism-specific databases

CTDi51386.
HGNCiHGNC:18138. EIF3L.
OpenTargetsiENSG00000100129.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3677. Eukaryota.
ENOG410XPJT. LUCA.
GeneTreeiENSGT00390000000411.
HOGENOMiHOG000265377.
HOVERGENiHBG001289.

Miscellaneous databases

ChiTaRSiEIF3L. human.
GenomeRNAii51386.

Gene expression databases

BgeeiENSG00000100129.
ExpressionAtlasiB0QY90. baseline and differential.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
HAMAPiMF_03011. eIF3l. 1 hit.
InterProiIPR019382. eIF3l.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR13242. PTHR13242. 1 hit.
PfamiPF10255. Paf67. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB0QY90_HUMAN
AccessioniPrimary (citable) accession number: B0QY90
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 30, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.