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Protein

Probable nicotinate-nucleotide adenylyltransferase

Gene

nadD

Organism
Clostridium sp. SS2/1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).UniRule annotation

Catalytic activityi

ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+.UniRule annotationSAAS annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable nicotinate-nucleotide adenylyltransferase (nadD)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processPyridine nucleotide biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00332.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable nicotinate-nucleotide adenylyltransferaseUniRule annotation (EC:2.7.7.18UniRule annotation)
Alternative name(s):
Deamido-NAD(+) diphosphorylaseUniRule annotation
Deamido-NAD(+) pyrophosphorylaseUniRule annotation
Nicotinate mononucleotide adenylyltransferaseUniRule annotation
Short name:
NaMN adenylyltransferaseUniRule annotation
Gene namesi
Name:nadDUniRule annotationImported
ORF Names:CLOSS21_01917Imported
OrganismiClostridium sp. SS2/1Imported
Taxonomic identifieri411484 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000004518 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliB0P1U3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 173CTP_transf_likeInterPro annotationAdd BLAST168

Sequence similaritiesi

Belongs to the NadD family.UniRule annotationSAAS annotation

Phylogenomic databases

OrthoDBiPOG091H028Y.

Family and domain databases

CDDicd02165. NMNAT. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00244. NaMN_adenylyltr. 1 hit.
InterProiView protein in InterPro
IPR004821. Cyt_trans-like.
IPR005248. NadD/NMNAT.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF01467. CTP_transf_like. 1 hit.
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00482. TIGR00482. 1 hit.

Sequencei

Sequence statusi: Complete.

B0P1U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKIGILGGT FNPIHHGHLI LGQAAKEEFG LDEILVMPTK NPAYKKISGG
60 70 80 90 100
VSEKNRVDMI KLAIRDFPYF KFSDIELKRE GTTYTVDTLR ELTKQDTDCR
110 120 130 140 150
YYFIMGADSL YQIETWKDPG QIFTMADILV ATRNDSRSAL DAQIDYLEEK
160 170 180 190 200
YDGKIYHLSS PSIEISSNDI RKRCSNGSSI HFFLPEDVID YIERNDLYGS

TADRRKA
Length:207
Mass (Da):23,663
Last modified:April 8, 2008 - v1
Checksum:iEFB29CF9A0CAC0F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABGC03000034 Genomic DNA. Translation: EDS21952.1.
RefSeqiWP_008391480.1. NZ_DS547001.1.

Genome annotation databases

EnsemblBacteriaiEDS21952; EDS21952; CLOSS21_01917.
GeneIDi31625811.

Similar proteinsi

Entry informationi

Entry nameiB0P1U3_9CLOT
AccessioniPrimary (citable) accession number: B0P1U3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: March 28, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported