Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tyrosine-protein kinase receptor

Gene

ltk

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • developmental pigmentation Source: ZFIN
  • iridophore differentiation Source: ZFIN
  • melanocyte differentiation Source: ZFIN
  • melanocyte migration Source: ZFIN
  • regulation of developmental pigmentation Source: ZFIN
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, ReceptorUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:ltkImported
Synonyms:shd(l)Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-030616-115. ltk.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei852 – 87928HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 15301505Tyrosine-protein kinase receptorSequence analysisPRO_5002750187Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation, PhosphoproteinUniRule annotation

Proteomic databases

PaxDbiB0LVZ8.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000061546.

Structurei

3D structure databases

ProteinModelPortaliB0LVZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 221171MAMInterPro annotationAdd
BLAST
Domaini275 – 436162MAMInterPro annotationAdd
BLAST
Domaini935 – 1211277Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.UniRule annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1095. Eukaryota.
ENOG410XPVX. LUCA.
HOGENOMiHOG000231766.
HOVERGENiHBG018726.
KOiK05119.

Family and domain databases

Gene3Di4.10.400.10. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR026984. LTK.
IPR000998. MAM_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PANTHERiPTHR24416:SF294. PTHR24416:SF294. 3 hits.
PfamiPF00629. MAM. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00192. LDLa. 1 hit.
SM00137. MAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
SSF56112. SSF56112. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS50060. MAM_2. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0LVZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYITRQTFV KLALFIFTVV RSSCALLEKA AESPVHPNPL QSSPAEDSDV
60 70 80 90 100
SFCDFESPCS WTLSSHSTGG EWFITSAQQH RSNRRDTQPI RDYSTGKSEG
110 120 130 140 150
HFLLLKPSSS HLSAARCSFH MTSPVVLSSG PFCHLQLARF QPEPHAGNIS
160 170 180 190 200
AFVKHTDSID IKPIDLTIKE QESDSSQWEV LEAVIGQLNE PFQVTVQYSA
210 220 230 240 250
CSSHEVGFLA FDSLELKNCV MGDDYVDLGS DCEKYSSLQC HSGGCIEKQR
260 270 280 290 300
VCDFHTDCPE GEDEGLICST LPLGSYCSFE LGSCGWSAAD TQSSWRLVSG
310 320 330 340 350
QQLIEDTHLL GTTLKNTQGH FLFLKVRGHG DEREALVQSP ALPSTISNQD
360 370 380 390 400
CQLQFSLYRY GDFNGTVLLS VVESGASAPA LIWERSGHWK DAWQEITLPI
410 420 430 440 450
TEILNGFHLK VQAFWTSGSK ADIALDDISL SAACFDTELN ELLHEGLPHD
460 470 480 490 500
LDFSPLPEPS ASEASPITWW FTSCGASGPF GPTQAQCDSA YRNTNVSVVV
510 520 530 540 550
GKEGPLRGVQ MWKVPATNTY KISAYGAAGG KGAKNHNKRS HGVFISATFP
560 570 580 590 600
LEKGDILYIL IGHQGEDACP GRNPQTHKIC LGESSVIEDG FDSDGSALKW
610 620 630 640 650
AGGGGGGGGA TYIYRMENGQ PLPLLIAAGG GGKAYLEDPE SSQDQSFREQ
660 670 680 690 700
YENDTTVSGV SGRSGAAGGG GGWSDVSSLS WAGKSLVEGG QGGSSCPEAL
710 720 730 740 750
SVLGWATFGG FGGGGGACSA GGGGGGYRGG DAPLLDDISA DGQDGLSFVH
760 770 780 790 800
PMGKIFLQSL AAMESHGEAE IVVYLNCSHC KTQSCKRDED TKLILCLCDS
810 820 830 840 850
DEVLAPDNVT CAGTKHSLCQ FINKHLQHNS SPLVCPPLVV PMGSLADGPP
860 870 880 890 900
SLVFIMAVIV STVVTGVVLT CASLTLIYYR KKNHLHAVRI RLQSPEYKLS
910 920 930 940 950
KIRSSTIMTD YNPNYGYFGK AASLSELKEV PRKNITLLRA LGHGAFGEVY
960 970 980 990 1000
EGQVLGMNGE NTAMQVAIKT LPEICSEQDE MDFLMEALIM SKFSHQNIVR
1010 1020 1030 1040 1050
CIGVSLQILP RFILLELMTG GDMKSFLRLN RPRTNHSSSL SMLELLHMAR
1060 1070 1080 1090 1100
DIALGCRYLE ENHFIHRDIA ARNCLLTCPG PDRVAKIGDF GMARDIYRAS
1110 1120 1130 1140 1150
YYRKGGRAML PVKWMPPEAF LEGIFTCKTD TWSFGVLLWE IFSLGYMPYP
1160 1170 1180 1190 1200
CKTNQEVLEF VTGGGRMDPP KSCPGPVYRI MTQCWQHCPE HRPNFTTILE
1210 1220 1230 1240 1250
RINYCTQDPD VINTPLPVEC GPPVEEEGGT VIRPDGSGSM TPLLVARSLS
1260 1270 1280 1290 1300
QDASPRASIT SVTPQALKPR LQLQRPVHLT QEVGTYRETL EPCWAEPVPA
1310 1320 1330 1340 1350
SGVCPGPWLQ VPEHRPCSRS SSSSGSQKLK NKTKNLWNPT YGSWVLESFG
1360 1370 1380 1390 1400
RGKSALCHTQ SMPLSCNPTS VSAPSSTSEH TDPVVEVNAN VSASPPPSAA
1410 1420 1430 1440 1450
PSQTTLTPTA APSRKSPTGA AGVSLATVMD LAKLQSFPCG NVNYAYDEQS
1460 1470 1480 1490 1500
YETESLPVVV SKSLEPSTSS AATSSLVALS QASSFTHKPL VKRHASYGHE
1510 1520 1530
DVRRYTQPEK PTRDRDSGFS LSEDLSVTPV
Length:1,530
Mass (Da):165,472
Last modified:March 18, 2008 - v1
Checksum:i055591F2F905BF8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU380906 mRNA. Translation: ABY83136.1.
RefSeqiNP_001006661.1. NM_001006660.1.
UniGeneiDr.108600.

Genome annotation databases

GeneIDi564470.
KEGGidre:564470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU380906 mRNA. Translation: ABY83136.1.
RefSeqiNP_001006661.1. NM_001006660.1.
UniGeneiDr.108600.

3D structure databases

ProteinModelPortaliB0LVZ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000061546.

Proteomic databases

PaxDbiB0LVZ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi564470.
KEGGidre:564470.

Organism-specific databases

CTDi4058.
ZFINiZDB-GENE-030616-115. ltk.

Phylogenomic databases

eggNOGiKOG1095. Eukaryota.
ENOG410XPVX. LUCA.
HOGENOMiHOG000231766.
HOVERGENiHBG018726.
KOiK05119.

Miscellaneous databases

NextBioi20885396.

Family and domain databases

Gene3Di4.10.400.10. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR026984. LTK.
IPR000998. MAM_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PANTHERiPTHR24416:SF294. PTHR24416:SF294. 3 hits.
PfamiPF00629. MAM. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00192. LDLa. 1 hit.
SM00137. MAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
SSF56112. SSF56112. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS50060. MAM_2. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. McAdow R., Johnson S.L.
    Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Leukocyte tyrosine kinase functions in pigment cell development."
    Lopes S.S., Kelsh R.N.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiB0LVZ8_DANRE
AccessioniPrimary (citable) accession number: B0LVZ8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 18, 2008
Last sequence update: March 18, 2008
Last modified: May 11, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.