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Protein
Submitted name:

Growth factor receptor-bound protein 2

Gene

GRB2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Growth factor receptor-bound protein 2Imported
Submitted name:
Growth factor receptor-bound protein 2, isoform CRA_aImported
Submitted name:
cDNA, FLJ96637, Homo sapiens growth factor receptor-bound protein 2 (GRB2), mRNAImported
Gene namesi
Name:GRB2Imported
ORF Names:hCG_27179Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000177885.13.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28962.

Expressioni

Gene expression databases

BgeeiENSG00000177885.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiB0LPF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 58SH3InterPro annotationAdd BLAST58
Domaini60 – 152SH2InterPro annotationAdd BLAST93
Domaini156 – 215SH3InterPro annotationAdd BLAST60

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3601. Eukaryota.
ENOG410XR1G. LUCA.
HOVERGENiHBG005404.
KOiK04364.
OMAiHWWHGEI.
OrthoDBiEOG091G0HWS.

Family and domain databases

CDDicd11949. SH3_GRB2_C. 1 hit.
cd11946. SH3_GRB2_N. 1 hit.
Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR030219. Grb2.
IPR035643. GRB2_C_SH3.
IPR035641. GRB2_N_SH3.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
IPR036028. SH3-like_dom_sf.
IPR001452. SH3_domain.
PANTHERiPTHR24418:SF290. PTHR24418:SF290. 1 hit.
PfamiView protein in Pfam
PF00017. SH2. 1 hit.
PF00018. SH3_1. 2 hits.
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF55550. SSF55550. 2 hits.
PROSITEiView protein in PROSITE
PS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.

Sequencei

Sequence statusi: Complete.

B0LPF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK
60 70 80 90 100
NYIEMKPHPW FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK
110 120 130 140 150
FGNDVQHFKV LRDGAGKYFL WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD
160 170 180 190 200
IEQVPQQPTY VQALFDFDPQ EDGELGFRRG DFIHVMDNSD PNWWKGACHG
210
QTGMFPRNYV TPVNRNV
Length:217
Mass (Da):25,206
Last modified:March 18, 2008 - v1
Checksum:i83A4B0BA1B248DC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU332843 Genomic DNA. Translation: ABY87532.1.
JX512444 Genomic DNA. Translation: AGC09591.1.
AK315565 mRNA. Translation: BAG37940.1.
CH471099 Genomic DNA. Translation: EAW89270.1.
RefSeqiNP_002077.1. NM_002086.4.
UniGeneiHs.444356.

Genome annotation databases

GeneIDi2885.
KEGGihsa:2885.

Similar proteinsi

Entry informationi

Entry nameiB0LPF3_HUMAN
AccessioniPrimary (citable) accession number: B0LPF3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 22, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.