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B0LPE5

- B0LPE5_HUMAN

UniProt

B0LPE5 - B0LPE5_HUMAN

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Protein
Submitted name:

V-akt murine thymoma viral oncogene homolog 1

Gene

AKT1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. aging Source: Ensembl
  2. apoptotic mitochondrial changes Source: Ensembl
  3. cell projection organization Source: Ensembl
  4. cellular response to epidermal growth factor stimulus Source: Ensembl
  5. cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: Ensembl
  6. cellular response to hypoxia Source: Ensembl
  7. cellular response to insulin stimulus Source: Ensembl
  8. cellular response to mechanical stimulus Source: Ensembl
  9. cellular response to organic cyclic compound Source: Ensembl
  10. execution phase of apoptosis Source: Ensembl
  11. germ cell development Source: Ensembl
  12. glucose homeostasis Source: Ensembl
  13. glucose metabolic process Source: Ensembl
  14. glucose transport Source: Ensembl
  15. glycogen biosynthetic process Source: Ensembl
  16. glycogen cell differentiation involved in embryonic placenta development Source: Ensembl
  17. hyaluronan metabolic process Source: Ensembl
  18. inflammatory response Source: Ensembl
  19. labyrinthine layer blood vessel development Source: Ensembl
  20. maternal placenta development Source: Ensembl
  21. negative regulation of apoptotic process Source: Ensembl
  22. negative regulation of cell size Source: Ensembl
  23. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  24. negative regulation of JNK cascade Source: Ensembl
  25. negative regulation of protein kinase activity Source: Ensembl
  26. negative regulation of release of cytochrome c from mitochondria Source: Ensembl
  27. osteoblast differentiation Source: Ensembl
  28. peptidyl-serine phosphorylation Source: Ensembl
  29. peripheral nervous system myelin maintenance Source: Ensembl
  30. positive regulation of apoptotic process Source: Ensembl
  31. positive regulation of cell growth Source: Ensembl
  32. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
  33. positive regulation of sodium ion transport Source: Ensembl
  34. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  35. positive regulation of vasoconstriction Source: Ensembl
  36. protein catabolic process Source: Ensembl
  37. protein kinase B signaling Source: Ensembl
  38. protein ubiquitination Source: Ensembl
  39. regulation of cell migration Source: Ensembl
  40. regulation of neuron projection development Source: Ensembl
  41. regulation of protein localization Source: Ensembl
  42. response to food Source: Ensembl
  43. striated muscle cell differentiation Source: Ensembl
  44. translation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
V-akt murine thymoma viral oncogene homolog 1Imported
Submitted name:
V-akt murine thymoma viral oncogene homolog 1, isoform CRA_aImported
Gene namesi
Name:AKT1Imported
ORF Names:hCG_96740Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cell-cell junction Source: Ensembl
  2. ciliary basal body Source: Ensembl
  3. cytosol Source: Ensembl
  4. microtubule cytoskeleton Source: HPA
  5. mitochondrion Source: Ensembl
  6. nucleus Source: HPA
  7. spindle Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24684.

Family & Domainsi

Sequence similaritiesi

Contains 1 PH domain.UniRule annotation
Contains AGC-kinase C-terminal domain.SAAS annotation
Contains PH domain.SAAS annotation

Phylogenomic databases

HOVERGENiHBG108317.
KOiK04456.
OMAiSRERVFP.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0LPE5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDVAIVKEG WLHKRGEYIK TWRPRYFLLK NDGTFIGYKE RPQDVDQREA
60 70 80 90 100
PLNNFSVAQC QLMKTERPRP NTFIIRCLQW TTVIERTFHV ETPEEREEWT
110 120 130 140 150
TAIQTVADGL KKQEEEEMDF RSGSPSDNSG AEEMEVSLAK PKHRVTMNEF
160 170 180 190 200
EYLKLLGKGT FGKVILVKEK ATGRYYAMKI LKKEVIVAKD EVAHTLTENR
210 220 230 240 250
VLQNSRHPFL TALKYSFQTH DRLCFVMEYA NGGELFFHLS RERVFSEDRA
260 270 280 290 300
RFYGAEIVSA LDYLHSEKNV VYRDLKLENL MLDKDGHIKI TDFGLCKEGI
310 320 330 340 350
KDGATMKTFC GTPEYLAPEV LEDNDYGRAV DWWGLGVVMY EMMCGRLPFY
360 370 380 390 400
NQDHEKLFEL ILMEEIRFPR TLGPEAKSLL SGLLKKDPKQ RLGGGSEDAK
410 420 430 440 450
EIMQHRFFAG IVWQHVYEKK LSPPFKPQVT SETDTRYFDE EFTAQMITIT
460 470 480
PPDQDDSMEC VDSERRPHFP QFSYSASGTA
Length:480
Mass (Da):55,686
Last modified:March 18, 2008 - v1
Checksum:i6EAFF4F8AD436714
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU332835 Genomic DNA. Translation: ABY87524.1.
JX512440 Genomic DNA. Translation: AGC09587.1.
CH471061 Genomic DNA. Translation: EAW81881.1.
CH471061 Genomic DNA. Translation: EAW81882.1.
CH471061 Genomic DNA. Translation: EAW81883.1.
RefSeqiNP_001014431.1. NM_001014431.1.
NP_001014432.1. NM_001014432.1.
NP_005154.2. NM_005163.2.
XP_005267458.1. XM_005267401.1.
UniGeneiHs.525622.

Genome annotation databases

GeneIDi207.
KEGGihsa:207.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU332835 Genomic DNA. Translation: ABY87524.1 .
JX512440 Genomic DNA. Translation: AGC09587.1 .
CH471061 Genomic DNA. Translation: EAW81881.1 .
CH471061 Genomic DNA. Translation: EAW81882.1 .
CH471061 Genomic DNA. Translation: EAW81883.1 .
RefSeqi NP_001014431.1. NM_001014431.1.
NP_001014432.1. NM_001014432.1.
NP_005154.2. NM_005163.2.
XP_005267458.1. XM_005267401.1.
UniGenei Hs.525622.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 207.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 207.
KEGGi hsa:207.

Organism-specific databases

CTDi 207.
PharmGKBi PA24684.

Phylogenomic databases

HOVERGENi HBG108317.
KOi K04456.
OMAi SRERVFP.

Miscellaneous databases

ChiTaRSi AKT1. human.
GenomeRNAii 207.
NextBioi 828.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE.
  3. Rieder M.J., Johanson E.J., da Ponte S.H., Hastings N.C., Ahearn M.O., Bertucci C.B., Wong M.W., Yi Q., Nickerson D.A.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiB0LPE5_HUMAN
AccessioniPrimary (citable) accession number: B0LPE5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 26, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.