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B0KW95

- CADH2_CALJA

UniProt

B0KW95 - CADH2_CALJA

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Protein
Cadherin-2
Gene
CDH2
Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism By similarity. In hippocampal neurons, may regulate dendritic spine density By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi262 – 2621Calcium 1 By similarity
Metal bindingi262 – 2621Calcium 2 By similarity
Metal bindingi293 – 2931Calcium 3 By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. blood vessel morphogenesis Source: Ensembl
  2. calcium-dependent cell-cell adhesion Source: Ensembl
  3. cell migration Source: Ensembl
  4. heterophilic cell-cell adhesion Source: Ensembl
  5. homophilic cell adhesion Source: Ensembl
  6. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  7. positive regulation of MAPK cascade Source: Ensembl
  8. striated muscle cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-2
Alternative name(s):
Neural cadherin
Short name:
N-cadherin
CD_antigen: CD325
Gene namesi
Name:CDH2
OrganismiCallithrix jacchus (White-tufted-ear marmoset)
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrix
ProteomesiUP000008225: Chromosome 13

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini160 – 724565Extracellular Reviewed prediction
Add
BLAST
Transmembranei725 – 74521Helical; Reviewed prediction
Add
BLAST
Topological domaini746 – 906161Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. catenin complex Source: Ensembl
  3. fascia adherens Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. lamellipodium Source: Ensembl
  6. synapse Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Propeptidei26 – 159134 By similarity
PRO_0000375873Add
BLAST
Chaini160 – 906747Cadherin-2
PRO_0000375874Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi190 – 1901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi273 – 2731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi325 – 3251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi402 – 4021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi572 – 5721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi622 – 6221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi651 – 6511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi692 – 6921N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PRIDEiB0KW95.

Interactioni

Subunit structurei

Interacts with CDCP1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN By similarity. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway By similarity.

Structurei

3D structure databases

ProteinModelPortaliB0KW95.
SMRiB0KW95. Positions 24-159, 161-373, 836-901.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini160 – 267108Cadherin 1
Add
BLAST
Domaini268 – 382115Cadherin 2
Add
BLAST
Domaini383 – 497115Cadherin 3
Add
BLAST
Domaini498 – 603106Cadherin 4
Add
BLAST
Domaini604 – 714111Cadherin 5
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi863 – 87816Ser-rich
Add
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Calcium-binding sites are occupied sequentially in the order of site 3, then site 2 and site 1 By similarity.

Sequence similaritiesi

Contains 5 cadherin domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000231254.
OMAiHSGHLQR.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR009124. Cadherin/Desmocollin.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01820. DESMOCOLLIN.
SMARTiSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0KW95-1 [UniParc]FASTAAdd to Basket

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MCRIAGAPRT LLPLLAALLQ ASVEASGEIA LCKTGFPEDV YSAVLSKDVH    50
EGQPLLNVKF SNCNGKRKVQ YESSEPADFK VDEDGMVYAV RSFPLSSEHA 100
KFLIYAQDKE TQEKWQVAVK LSLKPTLPEE SVKESTEVEE IVFPRQLGKH 150
SGHLQRQKRD WVIPPINLPE NSRGPFPQEL VRIRSDRDKN LSLRYSVTGP 200
GADQPPTGIF IINPISGQLS VTKPLDREQI ARFHLRAHAV DINGNQVENP 250
IDIVINVIDM NDNRPEFLHQ VWNGTVPEGS KPGTYVMTVT AIDADDPNAL 300
NGMLRYRILS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ 350
ATDMEGNPTY GLSNTATAII TVTDVNDNPP EFTAMTFYGE VPENRVDVIV 400
ANLTVTDKDQ PHTPAWNAVY RISGGDPTGR FAIQTDPNSN DGLVTVVKPI 450
DFETNRMFVL TVAAENQVPL AKGIQHPPQS TATVSVTVID VNENPYFAPN 500
PKIIRQEEGL HAGTMLTTFT AQDPDRYMQQ NIRYTKLSDP ANWLKIDPVN 550
GQITTIAILD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND 600
NAPQVLPQEA ETCETPDPNS INITALDYDI DPNAGPFAFD LPLSPVNIKR 650
NWTITRLNGD FAQLNLKIKF LEAGIYEVPI IITDSGNPPK SNISILRVKV 700
CQCDSNGDCT DVDRIVGAGL GTGAIIAILL CIIILLILVL MFVVWMKRRD 750
KERQAKQLLI DPEDDVRDNI LKYDEEGGGE EDQDYDLSQL QQPDTVEPDA 800
IKPVGIRRMD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL KAADNDPTAP 850
PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG EQDYDYLNDW GPRFKKLADM 900
YGGGDD 906
Length:906
Mass (Da):99,796
Last modified:March 18, 2008 - v1
Checksum:iE877E27E265C0393
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP000568 Genomic DNA. Translation: ABY79118.1.
RefSeqiXP_002757187.1. XM_002757141.1.

Genome annotation databases

EnsembliENSCJAT00000040785; ENSCJAP00000038607; ENSCJAG00000020748.
GeneIDi100411112.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP000568 Genomic DNA. Translation: ABY79118.1 .
RefSeqi XP_002757187.1. XM_002757141.1.

3D structure databases

ProteinModelPortali B0KW95.
SMRi B0KW95. Positions 24-159, 161-373, 836-901.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi B0KW95.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCJAT00000040785 ; ENSCJAP00000038607 ; ENSCJAG00000020748 .
GeneIDi 100411112.

Phylogenomic databases

HOGENOMi HOG000231254.
OMAi HSGHLQR.
TreeFami TF316817.

Family and domain databases

Gene3Di 2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR009124. Cadherin/Desmocollin.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
PR01820. DESMOCOLLIN.
SMARTi SM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 6 hits.
PROSITEi PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCADH2_CALJA
AccessioniPrimary (citable) accession number: B0KW95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: March 18, 2008
Last modified: February 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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