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B0KW95

- CADH2_CALJA

UniProt

B0KW95 - CADH2_CALJA

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Protein

Cadherin-2

Gene

CDH2

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism (By similarity). In hippocampal neurons, may regulate dendritic spine density (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi262 – 2621Calcium 1By similarity
Metal bindingi262 – 2621Calcium 2By similarity
Metal bindingi293 – 2931Calcium 3By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. blood vessel morphogenesis Source: Ensembl
  2. calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: Ensembl
  3. cell-cell adhesion mediated by cadherin Source: UniProtKB
  4. cell migration Source: Ensembl
  5. glial cell differentiation Source: UniProtKB
  6. heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: Ensembl
  7. homophilic cell adhesion via plasma membrane adhesion molecules Source: Ensembl
  8. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  9. neuronal stem cell maintenance Source: UniProtKB
  10. positive regulation of MAPK cascade Source: Ensembl
  11. striated muscle cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-2
Alternative name(s):
Neural cadherin
Short name:
N-cadherin
CD_antigen: CD325
Gene namesi
Name:CDH2
OrganismiCallithrix jacchus (White-tufted-ear marmoset)
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrix
ProteomesiUP000008225: Chromosome 13

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini160 – 724565ExtracellularSequence AnalysisAdd
BLAST
Transmembranei725 – 74521HelicalSequence AnalysisAdd
BLAST
Topological domaini746 – 906161CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. catenin complex Source: Ensembl
  3. extracellular vesicular exosome Source: Ensembl
  4. fascia adherens Source: Ensembl
  5. integral component of membrane Source: UniProtKB-KW
  6. lamellipodium Source: Ensembl
  7. synapse Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Propeptidei26 – 159134By similarityPRO_0000375873Add
BLAST
Chaini160 – 906747Cadherin-2PRO_0000375874Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi273 – 2731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi402 – 4021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi572 – 5721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi622 – 6221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi651 – 6511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi692 – 6921N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Cleaved by MMP24. Ectodomain cleavage leads to the generation of a soluble 90 kDa amino-terminal soluble fragment and a 45 kDa membrane-bound carboxy-terminal fragment 1 (CTF1), which is further cleaved by gamma-secretase into a 35 kDa. Cleavage in neural stem cells by MMP24 affects CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate neural stem cell quiescence (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PRIDEiB0KW95.

Interactioni

Subunit structurei

Interacts with CDCP1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN (By similarity). Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliB0KW95.
SMRiB0KW95. Positions 24-159, 161-373, 836-901.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini160 – 267108Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini268 – 382115Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini383 – 497115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini498 – 603106Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini604 – 714111Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi863 – 87816Ser-richAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Calcium-binding sites are occupied sequentially in the order of site 3, then site 2 and site 1 (By similarity).By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000231254.
InParanoidiB0KW95.
OMAiHSGHLQR.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR009124. Cadherin/Desmocollin.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01820. DESMOCOLLIN.
SMARTiSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0KW95-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCRIAGAPRT LLPLLAALLQ ASVEASGEIA LCKTGFPEDV YSAVLSKDVH
60 70 80 90 100
EGQPLLNVKF SNCNGKRKVQ YESSEPADFK VDEDGMVYAV RSFPLSSEHA
110 120 130 140 150
KFLIYAQDKE TQEKWQVAVK LSLKPTLPEE SVKESTEVEE IVFPRQLGKH
160 170 180 190 200
SGHLQRQKRD WVIPPINLPE NSRGPFPQEL VRIRSDRDKN LSLRYSVTGP
210 220 230 240 250
GADQPPTGIF IINPISGQLS VTKPLDREQI ARFHLRAHAV DINGNQVENP
260 270 280 290 300
IDIVINVIDM NDNRPEFLHQ VWNGTVPEGS KPGTYVMTVT AIDADDPNAL
310 320 330 340 350
NGMLRYRILS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ
360 370 380 390 400
ATDMEGNPTY GLSNTATAII TVTDVNDNPP EFTAMTFYGE VPENRVDVIV
410 420 430 440 450
ANLTVTDKDQ PHTPAWNAVY RISGGDPTGR FAIQTDPNSN DGLVTVVKPI
460 470 480 490 500
DFETNRMFVL TVAAENQVPL AKGIQHPPQS TATVSVTVID VNENPYFAPN
510 520 530 540 550
PKIIRQEEGL HAGTMLTTFT AQDPDRYMQQ NIRYTKLSDP ANWLKIDPVN
560 570 580 590 600
GQITTIAILD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND
610 620 630 640 650
NAPQVLPQEA ETCETPDPNS INITALDYDI DPNAGPFAFD LPLSPVNIKR
660 670 680 690 700
NWTITRLNGD FAQLNLKIKF LEAGIYEVPI IITDSGNPPK SNISILRVKV
710 720 730 740 750
CQCDSNGDCT DVDRIVGAGL GTGAIIAILL CIIILLILVL MFVVWMKRRD
760 770 780 790 800
KERQAKQLLI DPEDDVRDNI LKYDEEGGGE EDQDYDLSQL QQPDTVEPDA
810 820 830 840 850
IKPVGIRRMD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL KAADNDPTAP
860 870 880 890 900
PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG EQDYDYLNDW GPRFKKLADM

YGGGDD
Length:906
Mass (Da):99,796
Last modified:March 18, 2008 - v1
Checksum:iE877E27E265C0393
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000568 Genomic DNA. Translation: ABY79118.1.
RefSeqiXP_002757187.1. XM_002757141.2.

Genome annotation databases

EnsembliENSCJAT00000040785; ENSCJAP00000038607; ENSCJAG00000020748.
GeneIDi100411112.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000568 Genomic DNA. Translation: ABY79118.1 .
RefSeqi XP_002757187.1. XM_002757141.2.

3D structure databases

ProteinModelPortali B0KW95.
SMRi B0KW95. Positions 24-159, 161-373, 836-901.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi B0KW95.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCJAT00000040785 ; ENSCJAP00000038607 ; ENSCJAG00000020748 .
GeneIDi 100411112.

Organism-specific databases

CTDi 1000.

Phylogenomic databases

HOGENOMi HOG000231254.
InParanoidi B0KW95.
OMAi HSGHLQR.
TreeFami TF316817.

Family and domain databases

Gene3Di 2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR009124. Cadherin/Desmocollin.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
PR01820. DESMOCOLLIN.
SMARTi SM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 6 hits.
PROSITEi PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCADH2_CALJA
AccessioniPrimary (citable) accession number: B0KW95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: March 18, 2008
Last modified: November 26, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3